This paper describes the principle and circuit design of a new hemorrhoids therapy apparatus applied in anorectal surgery,Through clinical,practices in more than two years,it is proved to be an ideal instrument that can replace a variety of traditional hemorrhoids therapy methods.

Objective: To evaluate the outcomes of current studies regarding the beneficial effects of infant massage therapy. Method: Firstly, some common knowledge related to massage is provided. Subsequently, research-based evidence on massage effects in neonatal unit has been examined, particularly on premature babies and newborns with jaundice. Result and Conclusion: the practice of massage therapy promotes the development of preterm babies and the treatment of neonates with jaundice generally safe, however the methodology employed in reviewed studies is of certain limitations, such as a lack of RCT with large sample size, inadequate follow-up period.

Humans ; Laparoscopy

OBJECTIVE: To study the metabolites of phenoprolamine hydrochloride in human body and in human liver microsomes. METHODS: Two volunteers were administrated with 60 mg of phenoprolamine hydrochloride, and plasma samples were collected in specified time points; phenoprolamine hydrochloride was incubated in human liver microsomes. All the metabolites were identified with the LC-MS/MS system. RESULT: One key metabolite was detected in human plasma which m/z was 212.1. Six metabolites were detected in human liver microsomes and the m/z were separately 360.1, 342.2, 415.1, 281.4 and 330.2. Based on metabolite analysis, several metabolic pathways in human body and human liver microsomes were proposed. CONCLUSION: The metabolites of phenoprolamine hydrochloride in human body were different with that in human liver microsomes. We assumed phenoprolamine hydrochloride would metabolize mainly through other pathway but not in the liver. Copyright 2012 by the Chinese Pharmaceutical Association.

Objective To evaluate the clinical value of fetal holoprosencephaly complicated with face malformation by two-dimensional(2D) and three-dimensional(3D) ultrasonography.Methods Fetal faces and brains were examined regularly with 3D ultrasonography when they were suspected abnormal with 2D ultrasonography and compaired the diagnoses with postnatal or induced delivery results.Results 11 cases of holoprosencephaly complicated with face malformation were diagnosed using 2D and 3D ultrasonography.Among these cases,there were 4 with single median mostril,2 with proboscis,2 with cheiloschisis,2 with multipte face malformation,1 with arhinia.They were all comfirmed by postnatal or induced delivery.Conclusions 3D ultrasonography provides visualized,three-dimensional,more precise and clearly fetal structure imagine.It has important supplement to 2D ultrasonography.2D ultrasonography combined with 3D ultrasonography can greatly enhance the diagnosis rate to holoprosencephaly complicated with face malformation.

The cerebral hemodynamic disorders are most likely to occur in preterm infants, especially in extremely preterm infants with gestational age <28 weeks, due to the immaturity of cerebral vascular development and poor autoregulation of cerebral blood flow. Also the neurons, oligodendrocytes and their precursors in preterm infants are abnormally sensitive to hypoxia and ischemia with low tolerance and high vulnerability, which lead to a higher incidence of brain damage and neurological sequelae in preterm infants than that in full-term infants. Because brain injury in the premature often lacks the obvious nervous system symptom and the sign clinically, it is easy to be misdiagnosed and hence suitable treatment opportunity is missed. Cranial ultrasonography, MRI and EEG are the special examinations for early diagnosis of brain injury in preterm infants. In the diagnosis of early intracranial hemorrhage, cranial ultrasonography is superior to both MRI and EEG, but MRI especially DWI has the highest diagnostic value in the evaluation of leukoencephalomalacia, and EEG plays a supporting role in diagnosis of brain injury in each period. The three techniques have their own advantages and disadvantages. In clinical practice, if three techniques can be rationally used for the diagnosis of brain damage in preterm infants, it would be helpful to detect the disease in time and treat appropriately as soon as possible, and thus reduce the neurological sequelae and disability in preterm infants, and improve the long-term prognosis.

Objective To investigate the effect of Naoxintong capsule on clinical efficacy and inflammatory factors in patients with ischemic stroke.Methods 81 patients with ischemic stroke were divided into two groups according to random number table method.40 patients in the control group were treated with treatment guidelines,and the observation group was treated with another Naoxintong capsule.The serum interleukin-10(IL-10),tumor necrosis factor-a(TNF-α),high sensitivity C reactive protein (hs-CRP) level,National Institutes of Health Stroke Scale (NIHSS) and clinical efficacy of two groups were compared.Results After treatment,the hs-CRP,TNF-α levels of the observation group were (12.36 ± 3.09) mg/L,(129.62 ± 29.27) mg/L,which were lower than those of the control group[(1 6.71 ± 4.29) mg/L,(186.52 ± 37.62) ng/L,t =8.189,5.287,all P ＜ 0.05).After treatment for 7d and 30d,the NIHSS scores of the observation group were (14.28 ± 3.24) points,(5.23 ± 1.47) points,which were lower than those of the control group[(18.76 ±4.53)points,(8.16 ±2.42)points,t =14.689,12.827,all P ＜0.05].IL-10 level of the observation group was (49.82 ± 6.59) pg/mL,which was higher than (42.57 ± 9.82) pg/mL of the control group (t =6.759,P ＜ 0.05).The total effective rate of the observation group was 92.68％,which was higher than 77.50％ of the control group (x2 =4.897,P ＜ 0.05).Conclusion Naoxintong capsule has significant therapeutic effect on ischemic stroke,can effectively improve the inflammatory reaction after cerebral infarction,promote the recovery of neurological function and it is worthy of promotion.

The implementation of two-child policy has great significance.It can rationalize the population structure,diversify the family model,easethe pension problem significantly,and rationalize parent-child relationships.At the same time,there exist ethical problems in some aspects of society,such as the attribution of female reproductive fights,the anxiety the only child suffered from the second child,the continuing imbalance of gender,the occupational predicament of female reproduction,the effects on women health and family economy.Therefore,the country and society should respect and maintain women's reproductive rights,guarantee women's occupational stability,pay attention to the education of family ethics,promote the traditional values of respecting the old and cherishing the young,and develop the social old-age security system,thus to ensure the effective implementation of the two-child policy and build a harmonious family and society.

Objective To understand the dietary intake and nutritional status of pregnant women, and try to give a reasonable suggestion to promote the development of fetus. Methods 227 pregnant women in Changsha city were enrolled in this study. Their serum levels of vitamins were detected and their dietary intake were investigated. Results The ratio of the energy which was provided by dietary protein, carbohydrate and fat was appropriate. But the intake of dietary calcium, vitamin B1 and vitamin B2 was very low. With the development of gestation there were a remarkable rise in serum vitamin E level and decrease in serum folacin level, which was extremely obvious in the third trimester. It was about 40% of the pregnant women that the serum vitamin C level was lower than normal level. Conclusions Pregnant women tend to be lack of folacin, vitamin C and vitamin B 2.

In this study, a spectrophotometric detection method for diethylstilbestrol (DES) was proposed by reducing silver nitrate (AgNO3) to obtain silver nanoparticles (AgNPs) in the medium of ammonia and sodium hydroxide. It was found that the resulting AgNPs have plasmon resonance absorption (PRA) characteristic at 415 nm, and the PRA is proportional to the increase of DES concentration in the range of 4.0×10-8-1.0×10-5M with the detection limit (3σ) of 1.2×10-7M. Most of the coexisting substances at high concentrations did not affect the detection of real samples, such as tablets. The recovery was in the range of 96.01%-107.41% and the RSD was lower than 4.7%. This method can be successfully applied to control preparation quality of DES.