Stathmin, a ubiquitously expressed cytosolic protein(Mr=19×10~3), is also called oncogene protein 18 (Op18). Stathmin is involved in the assembly of microtubule (MT) and spindle by binding the tubulin protein. It plays a key role in cell proliferation, differentiation, regeneration, and migration and has regulatory effects on the signal transduction. Recently, it is reported that stathmin is overexpressed in a variety of human malignancies. It induces tumor cell migration and invasion by regulating MT depolymeri-zation. Its post-translational modification influences the interaction with p53 protein and is involved in the initiation and progression of malignant tumor. Stathmin alone or in combination with chemotherapeutics has been used for tumor therapy. The internal association of stathmin with cancer etiology is still unknown. So, further studies are needed to determine the role of stathmin as potential tumor biomarker and a drug target in tumor therapy.

Bibliometrics ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Medicine, Chinese Traditional

Objective To explore the clinical significance of joint detection of β2‐microglobulin(β2‐MG) ,glycated hemoglobin and Cystatin‐C (CysC) in early renal injury in patients with diabetes mellitus .Methods 60 patients with early diabetic renal damage were in early diabetic renal damage group and 100 patients with simple diabetes mellitus were in simple diabetes mellitus group .50 healthy persons were the control group .Using immunoturbidimetry to detect the serum level of CysC ,immunoturbidimetry trans‐mission to detect the urine level of β2‐microglobulin and ion exchange high performance liquid chromatography method to detect the level of HbA1c .Results There were statistically significant differences in the level of β2‐MG ,glycated hemoglobin between early diabetic renal damage group and the other two groups (P<0 .05) .There were statistically significant differenees in the level of gly‐cated hemoglobin between simple diabetes mellitus group and healthy control group (P<0 .05) .Conclusion It is important for pa‐tients with diabetes mellitus to detect the β2‐MG ,glycated Hemo globin and CysC in diagnosis ,monitoring .prevention of early renal injury .

The quality of life(QOL) in patients with nasopharyngeal carcinoma ( NPC ) has attracted people' s attention increasingly. Most of the studies focus on measuring scale and influential factor. Both the disease itself and many non-somatic factors can affect the patients' quality of life. In this review, we summarize these research advancements on measuring scales and influential factors, considering that it need more studies regard to quality of life in NPC patients, and it is very urgent and important to work out the special measuring scale of NPCQOL that suits Chinese culture and value system.

Anemia, Pernicious ; complications ; surgery ; Biopsy ; Endoscopy ; methods ; Humans ; Male ; Middle Aged ; Stomach Neoplasms ; complications ; surgery ; Tomography, X-Ray Computed ; methods ; Treatment Outcome ; Ultrasonography ; methods

OBJECTIVE:To improve the safety and effectiveness of total parenteral nutrition(TPN),and to provide reference for clinical rational use. METHODS:1400 TPN prescriptions in PIVAS from Jan. to Jun. 2013 were analyzed statistically in re-spects of rationality and stability. RESULTS:Among 1400 TPN prescriptions,there were 433 prescriptions of unreasonable glu-cose-lipid ratio(30.93%),782 prescriptions of unreasonable hot-nitrogen ratio(55.86%),443 prescriptions of unreasonable liquid amount(31.64%),1 261 prescriptions of unreasonable total calorie(90.07%)and 383 prescriptions of unreasonable treatment du-ration (27.36%). CONCLUSIONS:TPN prescription design is reasonable,but there are still some problems as low calorie,too high or too low hot nitrogen ratio,improper electrolyte dosage,improper duration of nutrition support. Clinicians should accurately assess the nutritional status of patients to design the prescriptions rationally and improve clinical safety and effectiveness of TPN. Pharmacists should further ensure the reasonableness of the prescription by prescription checking.

Objective To develop a sensitive,quick and convenient comet assay with Viciafaba root cells,so as to provide the reference for biomonitoring in situ.Methods The K_2CrO_7 and H_2O_2 were used as the positive control,the Viciafaba root cells isolated with mechanical and enzyme treatment respectively were exposed to the different concentrations of K_2CrO_7(1 nmol/L,10 nmol/L,100 nmol/L,1000 nmol/L)and H202(25 ? mol/L,50 ? mol/L,100 ?mol/L,200 ?mol/L).The effect of DNA damage was detected by using comet assay.Results The yield of Viciafaba root cells isolated from enzyme treatment were much higher than that from mechanical treatment.K_2CrO_7and H_2O_2 could cause DNA damage in Viciafaba root cells,there was significant difference between exposure group and control group(P

Objective In order to investigate and evaluate the heating-ventilating-air conditioning (HVAC) systems in the public areas and therefore provide the support for the hygiene management. Methods According to Hygiene Criterion of HVAC System, 10 HVAC systems in 10 star grade hotels in Nanchang were selected and PM10 and the total count of aerobic bacterial in the air condition systems, the collected dust weight and the total count of aerobic bacterial in the dust in the inner surface of ventilation vessels, the legionella bacteria in cooling tower water were determined. Results The HVAC systems in the 10 hotels, 90.1% for the PM10 and 73.3% for the total count of aerobic bacterial in the air condition systems, 8.9% for the collected dust weight and 86.7% for the total count of aerobic bacterial in the dust in the inner surface of ventilation vessels were over the standard limits, the legionella bacteria were detected in two of the investigated HVAC systems cooling tower water. Conclusion The hygienic problems are existed in the ventilated systems in the air conditioners in the pubic places.The health supervision and monitoring must go on enhancing.

control, P

There are increasing experimental evidences and clinical data showing that inflammatory reaction plays an important role in the production and development of atherosclerosis. Inflammatory process promotes the production and release of inflammatory factors by activation of monocytes and stimulation of endothelial cells, which stimulate the migration and proliferation of vascular smooth muscle cells. Hydrolases and cytokines are released from the activated and stimulated cells to increase local lesion and form atherosclerotic plaque with the development of inflammation. So, on the basis of the new pathogenesis of atherosclerosis,scientists try to interfere with atherosclerosis by anti-inflammatory pathway. This paper reviews the progress of drugs against atherosclerosis by the modulation of C reaction protein ,CD40-CD40L,infection and NF-?B.