1.Effects of Creatine Supplements on Contractile Properties of Skeletal Muscle in Elder Rats
Chinese Journal of Rehabilitation Theory and Practice 2013;19(6):527-531
Objective To investigate the effects of creatine supplement on contractile properties of soleus (SOL) and extensor digitorum longus (EDL) in elder rat. Methods 20 male Sprague-Dawley rats were randomly divided into control group and creatine supplement group with 10 rats in each group. After 6 weeks, the content of creatine and phosphocreatine were detected by high performance liquid chromatography,and contractile properties were examined in SOL and EDL in vitro at 30 ℃. Results The content of creatine and phosphocreatine both in SOL and EDL were higher in the creatine supplement group than in the control group (P<0.05). In SOL, creatine supplements increased the maximum twitch tension (Pt), maximum titanic tension(P0), decreased time to maximum twitch tension (TPT), but only time from maximum twitch to half relaxation (TPR50) significantly decreased, compared with the control group. In EDL, creatine supplements significantly increased Pt, P0 and decreased TPT (P<0.05). But there was no significant difference in TPR50 between 2 groups (P>0.05). Creatine supplements significantly increased the fatigue resistance of the SOL and there was no significant effect on EDL. The force potentiation which occurred in EDL during the initial 20~30 s of the fatigue test significantly increased (P<0.05). Conclusion Creatine supplement is effective on the contractile properties of SOL and EDL in elder rats, but the effect is dependent on the fiber types.
2.The progress of low-dose chemotherapy in neuroblastoma
International Journal of Pediatrics 2012;39(3):301-303
Low-dose chemotherapy is concerned in treating malignant tumor in recent years.The lowdose,metronomic chemotherapy is not only effective in antiangiogenic,but also avoid chemotherapy side effects,such as suppression of bone marrow,dysfunction of liver and kidney,gastrointestinal reaction and drug resistance.Thereby it can increase patient compliance,improve life quality and prolong survival time.Currently chemotherapy in neuroblastoma still plays a key role,especially low-dose chemotherapy,which can protect self-immune function and reduce the physical injury in children.
3.Therapeutic Observation of Acupuncture plus Rehabilitation Training for Post-stroke Dysphagia
Shanghai Journal of Acupuncture and Moxibustion 2017;36(8):910-913
Objective To observe the clinical efficacy of acupuncture plus rehabilitation training in improving post-stroke dysphagia. Method A total of 60 patients with post-stroke dysphagia were randomized into a treatment group and a control group, 30 cases in each group. The two groups were intervened by basic treatment of internal medicine and swallowing rehabilitation training, and the treatment group was additionally given acupuncture treatment. The Standardized Swallowing Assessment (SSA), water swallowing test and Swallowing Quality of Life Questionnaire (SWAL-QOL) were evaluated in the two groups before and after the treatment. Result After the treatment, the SSA scores in the two groups were significantly decreased compared to those before the treatment (P<0.01), and the SWAL-QOL scores were significantly increased compared to those before the treatment (P<0.01); the SSA score in the treatment group was significantly lower than that in the control group (P<0.01), and the SWAL-QOL score was significantly higher than that in the control group (P<0.05). The water swallowing test classification after the treatment was significantly superior to that before the treatment in the treatment group (P<0.01), and there was a significant difference compared to that in the control group (P<0.05). Conclusion Acupuncture plus rehabilitation training can obviously improve the swallowing function of patients with post-stroke dysphagia, and the clinical efficacy was superior to single rehabilitation training.
4.Application of comprehensive pain assessment scale to treatment of postherpetic neuralgia
Modern Clinical Nursing 2017;16(6):15-18
Objective To explore the application of the comprehensive pain assessment scale to the treatment of postherpetic neuralgia (PHN). Methods About 100 patients suffering from PHN were randomly divided into two groups: the control group and experiment group. The former was treated with recording for pain assessment and the latter was treated with the comprehensive pain assessment scale. Two sets of data were compared and analyzed in view of quality of sleep, average length of hospitalization and the duration of side effects of drugs. Result The effect of the experiment group was better than the control group in the quality of sleep, the average length of hospitalization, reduction of side effect duration of drugs (P<0.05). Conclusion The comprehensive pain assessment scale throughout the whole process of the PHN treatment can achieve timely and effective assessment of pain and reduce the side effect duration of drugs, improve their sleep quality, and shorten the hospital stay.
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