Objective To compare the differences between three kinds of reconstruction methods of the multi-planar spiral CT in diagnosing fractures of skull base , in order to appraise fractures of skull base in forensic medical examinations. Method 40 cases with suspicious basio-cranial fractures after cranio-cerebral trauma were examined by multi-planar spiral CT scanning. The data were imported into workstation for ax-ial scanning, multi-planar reconstruction (MPR) and 3D-reconstruction (using SSD). Results In 24 cases with anterior fossa fractures, 9 cases were found by axial scanning, 24 cases by MPR, 9 by SSD. The comparison between these groups showed significant statistical difference (P

OBJECTIVE:To investigate the application situation and tendency of antihypertensive drugs in our hospital. METHODS: By a retrospective study,a total of 952 prescriptions of outpatients with hypertension were sampled from our hospital from Nov. 18 to Dec. 17 in 2007 for statistical analysis regarding the utilization of antihypertensive drugs,the treatment regimens,sales amount,DDDs and DDC,etc. RESULTS: The antihypertensive drugs were mainly used in single or two kinds concomitantly. Calcium-channel blocker (CCB) and angiotensin receptor Ⅱ binders(ARB) took the lead,accounting for 30.67% and 28.45%,respectively. Leading the first three places on the list of DDDs were Telmisartan,Amlodipine and Benidipine,and leading the first three places on the list of sales amount were Telmisartan,Valsartan and Amlodipine. CONCLUSION:The use of antihypertensive drugs in our hospital conforms to China Guidelines on Prevention and Management of Hypertension and the drug use criteria recommended by WHO.

Objective To investigate the clinical effects of botulinum toxin A ( BTX-A) local injection treatment for hemifacial spasm .Methods Seventeen sites were used to inject BTX-A in 46 patients with hemifacial spasm . Before and after treatment , the grades of facial spasm were evaluated .Clinical efficacy was evaluated based on hemifacial spasm rating 4 weeks after treatment .The recurrence of symptoms in patients given repeated BTX-A injection.Results After BTX-A injection, 15 cases of completely relieved , obviously relieved in 29 cases, partial remission in 2 cases;the efficiency was 95.6%.The onset time was (2.6 ±1.1) d;sustained efficacy was (19.1 ± 2.3)weeks.Injection times was 1 in 5 cases, 2 in 23 cases, 3 in 11 cases and 4 or more in 7 cases.The onset time of repeated injection was(2.61 ±1.03) d, the duration was(19.24 ±2.12) weeks and the efficiency was 100%, They had no significant differences between initial and repeated injection .Six cases occurred local facial mild paralysis, and complete recovery after 2-4 weeks.Conclusion BTX-A local injection for hemifacial spasm is a safe and effective treatment , has no significant adverse reaction;and the effect of repeated injection is not decreased .

AIM: To optimize the parameters of processing for Arctium Lappa.METHODS: The contents of arctiin and arctigenin in Arctium Lappa were determined with HPLC,and the total yields of them were chosen as in-dex.The orthogonal test was adopted to acquire the optimum technology for processing Arctium Lappa.RESULTS: The study showed that the best processing parameters for Arctium Lappa consisted of 300 ℃ of the drying tempera-ture and 4-5 minutes of processing time.CONCLUSION: The processing method is reasonable,stable and reliable,and can be used in commercial production.

Objective To evaluate the efficacy of 0.1% tacrolimus ointment and 0.1% mometasone furoate cream in the treatment of chronic actinic dermatitis (CAD). Methods Forty male patients with CAD were recruited and divided into two groups randomly.Twenty cases were treated with 0.1%tacrolimus ointment (Group A), and the other 20 cases were treated with 0.1% mometasone furoate cream (Group B) . The medications mentioned were applied topically to the lesions on the face twice a day and mizolastine tablet 10 mg per day given orally for 4 weeks. The therapeutic efficacy and side effects of medications were observed. The enzyme linked immunosorbent assay (ELISA) method was used to measure the serum levels of IFN-γ, IL-2 and IL12 in CAD patients before and after treatment with topical tacrolimus ointment and mometasone furoate cream. Results (1) Both groups had overall response rates of 100%, with no statistically significant difference ( > 0.05) . (2) Serum levels of IFN-γ,IL-2 and IL-12 were down-regulated after treatment in both treatment groups respectively ( < 0.01) . No statistically significant difference was found between the two treatment groups ( > 0.05) . Conclusion 0.1%tacrolimus ointment is effective in the treatment of CAD. Its therapeutic efficacy is equivalent to that of 0.1%mometasone furoate cream. It can be used as a possible steroid sparing equivalent.

To examine the actual clinical diagnosis capability,the import of computer-based case simulations ( CCS ) technology in medical education is very important.The CCS examination system that integrated the ASP.NET and CCS technology can simulate doctor's clinical course more realistically and realize the students' practical skills evaluation.The system has a good prospect in medical education and clinical skills training.

Purpose To develop the Pharmic Information Consulting System and apply it to clinic or outpatient department so that doctors can consult the pharmic information quickly.Method Based on PowerBuider9.0 and the net in our sanatorium,a standard and practical pharmic information list was made by using Oracle7.3 database software.Result With this system the following functions can be available including pharmic information management,pharmic information retrieving,new medicine information provision,hospital information provision,adverse drug reactions announcement,pharmic education,etc.This system is a very useful tool for pharmaceutists,doctors even nurses.Pharmaceutists can use it to collect,save and classify pharmic information.Doctors can use it to consult the pharmic information quickly.Conclusion Using net service mode,this system shows such characteristics as speediness,exactness,adjustability and expandability.It is fit for the service of pharmic information and is valuable to be popularizd.

OBJECTIVE:To improve hydroscopicity and fluidity of traditional Chinese drug extractum by spray drying and to improve affixes to the wall of the drier during drying for providing reasonable relative humidity of production.METHODS:The compounding of adjuvant and the technology were optimized by orthogonal experiment,and the hydroscopicity and fluidity of powdered extract were investigated.RESULTS:The hydroscopicity of traditional Chinese drug extractum can be greatly decreased by adding 3% gum arabic and 7% ?-CD.The optimum technological conditions were as follows:extractum density of 1.10g? mL-1,temperature of intake airflow of 170℃,atomization pressure of 0.5Mpa,and feed material speed of 400mL? h-1 by orthogonal experiment.The critical relative humidity of the optimum formula was 64%.CONCLUTION:The problems of time consuming and moisture absorption of traditional Chinese drug extractum existed in the traditional old technology can be improved in this new technology.

OBJECTIVE:To discuss the way for clinical pharmacists to carry out pharmaceutical care.METHODS:We summarized the content,method and experiences of carrying out pharmaceutical care based on our clinical practice in Cardiology department.RESULTS & CONCLUSION:To provide all-round high quality pharmaceutical care for patients,clinical pharmacists should improve their own qualities by continuous learning knowledge and theories related to their own profession as well as improving their practical skills.

Objective To establish a method to analyze the composition and content of monoses in the garlic polysaccharide by ion chromatography. Methods The monoses in the solution of garlic polysaccharide hydrolysised by trifluoroacetic acid were determined by amino PAC column, eluted by gradient hydroxide sodium and identified by ampere detector (AU as working electrode, Ag/AgCl as reference electrode). Results The garlic polysaccharide was mainly composed by arabinose, galactose, glucose, xylose and fructose. Good resolution could be achieved among the above mentioned five kinds of monoses. Their linear correlations over the investigated concentration were above 0.998, while the average recovery rates were in the range of 95%-105%. Conclusion The ion chromatography method is fast, accurate, simple and reliable, and can be applied in the content determination and quality control of garlic polysaccharide.