Asthma,a chronic inflammatory airway disease,is influenced by both genetic and environmental factors.It is a complex disease that involves the interplay among multiple physiological processes.Currently,it has been identified that 17q21 loci genes especially orosomucoid like 3 (ORMDL3) and gasdermin B (GSMDB) are strongly linked with the susceptibility and severity of childhood asthma by using of the Genome-Wide Association Study (GWAS).Furthermore,a better understanding of the molecular mechanism contributes to the asthma target therapeutics and precision medicine.This review summarizes the 17q21 loci genes associated with the susceptibility,severity,and race specificities of childhood asthma.

Along with the rising of Chinese medicine consumption,health food with Chinese medical feature plays an increasingly role in people's life,and its market shares increase every year.This article analyzes the advantages from aspects of literature,theory,function,security,resources and market of health food,in order to develop health food and inherit the theory of Chinese medicine.

Objective To explore the cardiac function of right ventricles in children with various course of bronchial asthma. Methods The cardiac function was evaluated by using the Doppler echocardiography in 36 chil-dren with course > 1 year bronchial asthma in remission stage and 38 children with course ≤ 1 year bronchial asthma in remission stage. 40 healthy children were used as normal controls. After treatment, 10 children with course > 1 year were evaluated again. Results The injury of right ventricle systolic function was predominant in children with > 1 year bronchial asthma, The systolic function of right ventricle remained normal in children with ≤ 1 year bronchi-al asthma. Conclusion The cardiac function damage occurs in children with > 1 year bronchial asthma and will be recoveied by cure the astham. The Doppler echocardiography is noninvasive method for determination of cardiac func-tion.

OBJECTIVE:To evaluate the safety of several pretreatment protocols of paclitaxel liposome as a chemotherapy for upper gastrointestinal tumor.METHODS:26 patients with upper gastrointestinal tumors receiving paclitaxel liposome in combination with other chemotherapeutics were enrolled.The patients were injected intravenously with dexamethasone 10 mg (i ) or dexamethasone 5 mg(ii ) or prednisolone 40 mg(iii ) 30 minutes prior administration of paclitaxel liposome,or treated with oral dexamethasone at a dose of 6 mg(i ),4.5 mg(ii ) or 2.25 mg(iii ) 12 hours or 2 hours prior administration of paclitaxel liposome.RESULTS:Chemotherapy- induced toxic adverse reactions manifested as gradeⅠ～Ⅱleucopenia,anemia, nausea and vomiting,but recovered after symptomatic treatment.Pretreatment- related adverse reactions manifested as insomnia, hyperglycemia,fatigue and vertigo,but no allergic shock or treatment- related death occurred.CONCLUSION:Intravenous injection of prednisolone 40 mg 30 minutes prior administration of paclitaxel liposome or oral administration of dexamethasone 2.25 mg 12 hours and 2 hours prior administration of paclitaxel liposome are preferable pretreatment methods of paclitaxel liposome.

To improve the quality of teaching is the core task of the development of higher education,and effective teaching is the fundamental guarantee to promote students to learn effectively,and to improve the teaching quality and talents cultivation quality,which has very important significance to exploring the effective teaching idea and implementation strategy.In the teaching of medical immunology for example,the author combined the characteristics of the course,and had a preliminary discussion on the feature of effective teaching,to explore the effective teaching strategies of thought guiding before class,creating context in class,autonomous learning at recess,teaching reflection after class,to provide reference for college teachers to improve teaching ability and teaching effectiveness.

Objective To explore the serum levels of cytokines in patients with depression and their correlations with sex,age,depression severity and anxiety severity.Methods After enrolling subjects into the corresponding patient group and control group,the same trained researcher should continue to collect general information of the enrolled subjects as well as the HAMA and HAMD scoring results collection and assessment;And the serum levels of interlukin-1β (IL-1β),interlukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were detected with the method of enzyme-linked Immuno-sorbent assay (ELISA) in two groups.Results ① The serum levels of IL-1β,IL-6 and TNF-α of depression group were significantly higher than these in control group (P＜0.05),which were ((5.45±3.60) pg/ml vs(2.63± 1.92) pg/ml,(5.09±3.74) pg/ml vs (3.83±2.71) pg/ml,(5.77±3.94) pg/ml vs (4.05±3.25) pg/ml) respectively.②There was no significant difference in serum levels of IL-1 β,IL-6 and TNF-α between male and female patients with depression (P＞0.05).③ No conspicuous differences were found between the young group and the middle-aged group in serum levels of IL-1β,IL-6,TNF-α (P＞0.05).④ Serum level of IL-6 in major depressive disorder group((6.24±4.68) pg/ml) was more higher than that in mild to moderate depression group((3.95± 1.97)pg/ml),and the difference was statistically significant (t=2.467,P＜0.05).⑤There was significant differences in serum level of IL-6 between two groups,which were depression patients with and without anxiety (separately(5.80±4.37) pg/ml vs(3.87±1.80) pg/ml) (t=2.397,P＜0.05).Conclusions ①There is a phenomenon of immune activation,and levels of blood cytokines are raised in patients with depression.②Age and gender have no impact on depression in the level of cytokines.③IL-6 may be an important biological index that reflected the severity of depression and anxiety.

AIM: To study the effect of G-protein-coupled receptor kinase 5 (GRK5) on the activation of astrocytesin the brain cortex of newborn Wistar rats .METHODS: GRK5 gene was silenced in the model of rat brain cortexastrocytes in vitro for 24 h.N-acetylcysteine (NAC), which is a known inhibitor of NF-κB, was added into the culture mediumaccording to gene silencing for 24 h.The expression levels of GFAP and caspase-3 were detected by the method of immunofluorescence,and the mRNA levels of NF-κB, TNF-α, IL-1βand iNOS were determined by real-time PCR.Moreover,the activity of SOD and concentrations of TNF -αand NO were measured.RESULTS: GRK5 gene silencing increasedthe expression of NF-κB at mRNA and protein levels obviously (P <0.01), and the mRNA levels of IL-1βand iNOS increasedsynchronously (P <0.01).Furthermore, caspase-3-positive cells in GRK5 siRNA group were increased comparedwith control siRNA group (P <0.01).Treatment with NAC obviously reduced the activity of NF -κB and weakened theeffects induced by GRK5 siRNA (P <0.05).CONCLUSION: GRK5 siRNA increases NF-κB activity and induces the activationof astrocytes.

AIM:To observe the clinical effect of combination therapy with ozagrel and low molecular weight heparin on progressive cerebral infarction.METHODS:96 cases with acute progressive cerebral infarction were randomly divided into treatment group(48 cases)and control group(48 cases).The control group was only administered with 80 mg sodium ozagrel,bid,for 14 days.And the treatment group was administered with 80 mg sodium ozagrel,bid,for 14 days and 0.4 mL low molecular weight heparin sodium injection,bid,for 14 days.The number of platelet,blood clotting routine and the severity of neuro-functional defect(NDS)of both groups were detected before and after 14 days treatmeat.RESULTS:After 14 days treatment,the NDS of treatment group was significantly lower than that of control group(P

Health food has been used for a long history in our country,and it has unique advantages and is an important part of national medical care delivery in China. Up to now,its use is not under administration of food safety law. This article analyzes the differences among health food,drug and common food,the advantages in theory,resource,safety and compatibility of health food,the laws and regulations of health food published by government,and the status of health food industry,in order to demonstrate the importance and urgency of health food being administrated under food safety law,for the purpose of obtaining the academic and legal consensus.

AIM:To choose the optimal processing condition for stir-frying Radix et Rhizoma Glycyrrhizae with honey.METHODS:The contents of glycyrrhizic acid and liquiritin and macroscopical identification were selected as indexes according to orthogonal design L9(34),four factors including the proportion of processed honey and water,soaking moistening time,drying temperature,and drying time.RESULTS:Optional processing conditions consisted of using two part processed honey to one part water as mixture,30 min soaring moistening time,oven temperature rose to 130 ?C and keeping for 20 min.CONCLUSION:The above processing can make the contents of glycyrrhizic acid liquiritin maintaining more 2.33%(RSD 0.43%) and 0.9%(RSD 1.10%),the optimal honey-fried processing technology for Radix et Rhizoma Glycyrrhizae is reasonable.