1.Curative effect analysis of ultrashort wave combined with dephlogisticate cholagogue table in treating patients with chronic cholecystitis
Chinese Journal of Postgraduates of Medicine 2012;35(18):28-30
Objective To evaluate the clinical effect of ultrashort wave combined with dephlogisticate cholagogue table in treating patients with chronic cholecystitis.Methods One hundred and forty-four patients with chronic cholecystitis treated from January 2009 to October 2011 were randomly divided into 2gtoupe by mechanical sampling method.Treatment group (76 cases) was treated with ultrashort wave and dephlogisticate cholagogue table.Control group (68 cases) was treated with dephlogisticate cholagogue table.The therapeutic effect and the incidence of ache and fever and B-type ultrasonography between two groups were compared.Results The total effective rates were 89.5% (68/76) in treatment group and 67.6%(46/68) in control group.There was significant difference (P <0.01).The incidence of ache and fever,positive rate of B-type ultrasonography in tneatment group [10.5%(8/76),5.3%(4/76),10.5%(8/76)] were significantly lower than those in control group [32.4% (22/68),14.7% (10/68),33.8%(23/68)] (P < 0.05).Conclusion Ultrashort wave combined with dephlogisticate cholagogue tabble is an effective method for treating chronic cholecystitis.
2.The heart function efficacy of recombinant human B-type natriouretic peptide in peripartum cardiomyopathy with refractory heart failure
Juping WEI ; Likui GUO ; Xinna FAN ; Jing ZHANG
Clinical Medicine of China 2015;31(8):673-677
Objective To investigate the efficacy of recombinent human B-type natriuretic peptide (rhBNP) in peripartum cardiomyopathy (PPCM) with refractory heart failure (RHF).Methods From January 2010 to January 2014,a total of 61 patients with PPCM-RHF of the First Hospital of Qinhuangdao were enrolled into this study.All patients were randomly assigned into the rhBNP group (30 cases) and control group (31 cases).rhBNP was given 1.5 μg/kg,2 mim intravenously in rhBNP group and then infused intravenously 0.007 5-0.030 μg/(kg · min) for 24 hours,0.015-0.030 μg/(kg · min) for 24 hours when systolic blood pressure(SBP) ≥ 85 mmHg (1 mmHg =0.133 kPa) and mean brachial arterial pressure (MBP) ≥ 65 mmHg.Routine therapy followed the clinic practice was administrated in control group for 24 hours.Recorded the dyspnea change.Blood samples were collected at different time points to investigate BNP at 6 h,14 d and 30 d.Ultrasonic cardiography (UCG) was performed to evaluate left ventricular ejection fraction (LVEF) and left ventricular end-diastolic dimension(LVEDD) before the initiation of the infusion,at day 1,14 and 30 after the infusion.All patients were followed up for one month to record the main adverse cardiac events (MACE),including heart failure recurrence,cardiac death and ventricular fibrillation and tachycardia.Results The time of dyspnea resolved in rhBNP group was significantly shorter than control group ((1.69 ± 1.07) h vs (2.69 ±1.39) h,P =0.002).Concentration of plasma BNP(6 h:(296.50±123.25) ng/L,14 d:(141.37±69.54) ng/L,30 d:(107.41±33.69) ng/L) was signifisantly reduced in both groups than basic line (727.07 =± 146.84) ng/L,and it was significantly different between two groups.LVEF raised and LVEDD decreased were observed at 24 hours((52.23±4.54) mm),14 d((49.60±4.20) mm) and 30 d((42.59±3.90) mm) in rhBNP group and were significant better than the control group ((56.33 ± 4.38) mm,(53.03 ± 4.95) mm,(48.85±4.96) mm;P <0.05).There was no significant difference in term of LVEF between two groups after treatment.However,24 h(4.12±41.13)%,14 d(4.10±43)%,30 d(44.52±3.43)% were significantly higher than the baseline(36.73±5.82)% in rhBNP group.MACEs were lower in rhBNP group at 30 dayscontrast to the control(10% (3/30) vs.42% (13/31);P =0.005).Conclusion Compared with conventional treatment,rhBNP can effectively improve the heart function in patients with PPCM-RHF,reduce the occurrence of major adverse cardiac events in 30 d,and improve the prognosis of patients.