Objective To investigate the psychological state and its correlation factors of family members of elderly cancer patients. Methods A total of 76 family members of elderly cancer patients were investigated with questionnaires with Zung's self-rating anxiety scale (SAS) and self-rating depression scale (SDS). Their psychological state and its correlation factors were analyzed. Results Incidence rate of anxiety of elderly cancer patients' family members was 52.63%, and incidence rate of depression was 46.05%. The mean standard score of SAS and SDS of elderly cancer patients' family members were both significantly higher than domestic norm. Difference of family member's gender, ways to pay health care fee, pain degree and disease condition led to different SAS and SDS score. Conclusions Family members of elderly cancer patients possessed different degree of psychological obstacle which related with multiple factors. Medical staff should not only think highly of patients' psychological state, but also their family members'. And meanwhile they should take corresponding strategy to reduce the incidence rate of anxiety and depression state in those family members.

This report presents two cases of unilateral acute labyrinth loss resulted from injury,each showing delay in compensation possibly due to long-term administration of diazepam.The recent literature of the effects of the drugs onyestibular compensation is reviewed.The vestibular"suppressants"property of diazepam delays compensation when used on a long-term basis.However,it might be useful in controlling vege- tative symptoms and thereby possibly facilitate compensation when used on a short- tern basis.

Objective The purpose of the present study was to explore the use of psychological intervention in modified electroconvulsive therapy patients.Methods Divide all 160 patients random into two groups,the intervened group and the contrast group. The intervened group was accepted psychological intervention before the therapy day;The contrast group just did as normal.Record the anxiety, blood pressure,heart rate and the agreement to the therapy of the two group before the therapy.Results The anxiety of the intervened group was much little to the contrast group.The blood pressure and the heart rate of the intervened group was lower than the contrast group.Patient of the intervened group was much active to match with the treatment. Conclusions The use of psychological intervention in modified electroconvulsive therapy patients could decrease patient’s anxiety and painness,made them more active to match with the treatment.

Objective: To explore correlation among concentrations of high sensitive C reactive protein (hsCRP), uric acid (UA), brain natriuretic peptide (BNP) and coronary heart disease (CHD).Methods: A total of 120 CHD patients treated in our department were enrolled as CHD group, and they were divided into single vessel coronary disease group (single-vessel group, n=51) and multi-vessel coronary disease group (multi-vessel group, n=69).Meanwhile, another 40 healthy subjects were randomly selected from our physical examination center as healthy control group.Serum concentrations of hsCRP, BNP and UA were measured in all groups, and compared with pairwise comparisons.Results: Compared with healthy control group, there were significant rise in serum concentrations of hsCRP[(3.95±2.24) mg/L vs.(19.78±5.15) mg/L], BNP[(70.57±19.47) pg/ml vs.(196.17±54.84) pg/ml], UA[(184.51±79.47) μmol/L vs.(407.17±96.84) μmol/L]in CHD group, and those of multi-vessel group were significantly higher than those of single-vessel group, P<0.05 or <0.01;Spearman rank correlation analysis indicated that serum UA concentration was significant positively correlated with hsCRP and BNP concentrations (r=0.551, 0.398, P<0.05 both), Gensini score was significant positively correlated with serum concentrations of hsCRP, BNP, UA (r=0.478, 0.552, 0.741, P<0.05 all), Sullivan score was significant positively correlated with serum concentrations of hsCRP, BNP, UA (r=0.503, 0.674, 0.892, P<0.05 or <0.01) in CHD patients.Conclusion: Serum concentrations of hsCRP, BNP, UA are closely related to occurrence and development of CHD.These three indexes can be used as screening indexes for CHD, and the effect of combined detection may be better.

ObjectiveTo compare the levels and locations of metalloprotionase-2（MMP-2），collagen types Ⅰ and Ⅵ in keratoconus and normal human corneas．MethodsAn immunoperoxidase and indirect immunofluorescent technique were used to visualize the presence of collagen types Ⅰ， Ⅵ and MMP-2．The immunohistochemical staining was further analyzed and the intensity of reaction products was measured with an Image-processing system．ResultsCollagen type Ⅰ was demonstrated immunohistochemicall and indirect immunofluorescent technique in the bowman and stroma layers；collagen type Ⅵ was in epithelium basement，bowman，stroma and descement layers；MMP-2 was in epithelium，stroma and endothelium of all corneal sections．Compared with normal control specimens，the staining intensity of collagen types Ⅰ and Ⅵ was similar，while MMP-2 was markly increased．ConclusionsKeratoconus contained an increased level of MMP-2 and similar of collagen levels．These results lead further support to the hypothesis that degradation processes may be aberrant in keratoconus．

Objective To explore the role of astrocytes transient receptor potential channel 6(TRPC6) in rat brain injury (TBI).Methods Thirty-nine male Sprague-Dawley(SD) rats were divided into the sham operation group,injury group and deferoxamine(DFX) group(n=13).According to the previous model construction scheme established by our research group Feeney method,the rat brain impact injury model was established.The Morris water maze test was performed and the defected brain volume was measured.The immunofluorescence was adopted to detect the co-expression of TRPC6 and GFAP.Then Western blot was performed.Results The defected brain volume after TBI in the DFX group was significantly decreased compared with the injury group [(115.35 ± 13.70)mm3 vs.(209.99 ± 16.70)mm3]] (P＜0.05).The Morris water maze test found that the platform search strategy and search time in the DFX group were(3.13 ± 0.35) and(36.15 ± 26.63)s,which were significantly improve d compared with (2.13±0.64) and(110±47.34)s in the injury group(P＜0.05).The immunofluorescence found that GFAP in the DFX group was highly expressed,moreover the co-expression with TRPC6 was increased.Western blot found that TRPC6 in the DFX group was significantly down-regulated(P＜0.01).Conclusion In rat TBI early stage,strocytes are activated after DFX treatment and TRPC6 is highly expressed,playing a neuroprotective role.

Objective　To appraise the real situation of lega l contagious diseases exactly, to find and to correct the problems in reportin g epidemic diseases in time. Methods　Census and sampling surve y were applied in the different level medical institutions and inhabitants to in vestigate the legal contagious diseases failed to report. Results　13 species of legal contagious diseases were found out in medical institutio ns, amouted to 5 917 cases, and the rate failed to report was 29.85%; there wa s signifi cant difference in different medical institutions; 9 species of legal contagious diseases amouted to 546 cases were found out in 56 947 inhabitants, and its inc idence rate was 505.73 per 100 000, while the rate failed to report was 48.71%. C onclusions　We should strengthen the reporting of epidemic disease in ru ral and indiviual medical institutions.

Currently, the commonly used diagnostic markers have the shortcomings of lower sensitivity or specificity in the early diagnosis of cardio-cerebrovascular diseases. Therefore, it needs to use the novel specific biochemical markers for the early diagnosis arid treatment, so as to decrease the high mortality and disability caused by cardio-cerebrovascular events. Fatty acid-binding proteins (FABPs) are a family of low-molecular-weight intracellular lipid-binding proteins. They are divided into 9 different subtypes, including the liver-, intestinal-, heart-, brain-, adipocyte-, skin-, ileal-, myelin-, and testis-subtype. Their primary function is to transport long-chain fatty acids into the cells, and thus regulate intracellular lipid metabolism. The structures of all FABP subtypes are similar, inclusive of two α2 helices arid one β2 fold structure. Among them, the sensitivities and specificities of the heart- and brain-subtype FABPs are higher in the early diagnosis of cardio-cerebrovascular diseases. It is promising to become the novel markers in the early diagnosis of cardio-cerebrovascular diseases.

Objective To discuss the application of insulation blanket in the esophageal cancer radical surgery.Methods 40 cases of esophageal carcinoma patients were divided into two groups at random,20 cases involved in the control group (non-use of insulation blankets) and 20 cases in the experimental group (use of thermal insulation blanket).The changes in body temperature of all patients were monitored with nasopharyngeal temperature probe and analyzed in statistics.Results Compared to the control group,the body temperatures of the experimental group were higher.By heating with insulation blanket,the body temperatures were increased obviously in 30 minutes after entering the operation room,but no significant difference appeared at different time points after 30 minutes.Conclusions In radical surgery of esophageal cancer,the use of blanket insulation is an effective way to maintain a constant body temperature of patients and reduce post-operative complications,and promote early recovery of patients.

Objective To explore the clinical effect of fleabanein in treatment of acute cerebral infarction.Methods 42 cases were randomly divided into treatment group(22 cases) and control group(20 cases).Treament group is given iv.fleabanein and compared with control group.Results The cured and effective cases of treatment group is 18 cases,that of control group is 8 cases,there is obvious difference(P < 0.05).Conclusion Fleabanein has better effect on acute cerebral infarction.