1.Effect of Bailong Jieyu Granules on Qulity of Life of Patients with Cancer-ralated Depression
Yuxing YANG ; Pinkang WEI ; Lijuan XIU
Chinese Journal of Information on Traditional Chinese Medicine 2006;0(05):-
Objective To observe the influence of Bailong Jieyu Granules on quality of life (QOL) of patients with cancer-ralated depression. Methods A prospective and self-control clinical trial was carried out. Sixty seven patients with cancer-ralated depression were chosen and treated with Bailong Jieyu Granules. EORTC QLQ-C30 3.0 scores of patients were assessed before and after the treatment. Results After treatment of Bailong Jieyu Granules, the scores of role function, emotional function and global quality of life were increased, while the scores of fatigue, nausea/vomiting, insomnia and appetite loss were decreased, there were significant differences (P
2.Clinical Study on Headache due to Nitroglycerin Remitted with Ice Covering Head
Xiaoming HE ; Yingju XIU ; Lijuan SUN ; Jing LIU
Chinese Journal of Practical Nursing 2001;17(6):19-20
Objective To study whether covering ice on head can abate headache produced by using nitroglycerin.Method 64 cases were collected from the patients who used nitroglycerin and were randomly divided into one contrasting group (group A) and one experimental group (group B).For the patients of group A,the state of headache produced by using nitroglycerin should be observed.For the patients of group B,covering ice on their head was adopted when they used nitroglycerin,and the state of headache should also be observed.Results There were obvious difference between the two groups (P<0.001).Conclusion Covering ice on head is a good method which can abate headache produced by using nitroglycerin.
3.Effects ofXiaotan Sanjie Decoction on Ultramicrostructure in MKN-45 Human Gastric Cancer Orthotopic Xenograft
Min YE ; Dazhi SUN ; Lijuan XIU ; Ye LU ; Pinkang WEI
Chinese Journal of Information on Traditional Chinese Medicine 2015;(9):60-62
Objective To observe the effects ofXiaotan Sanjie Decoction on ultramicrostructure in MKN-45 human gastric cancer orthotopic xenograft;To discuss its mechanism for gastric cancer. Methods MKN-45 human gastric cancer cell line was used to establish subcutaneous tumor model in nude mice as an experimental model which passed three generations of tumor source. Then OB glue was used to establish human gastric cancer orthotopic xenograft model. 40 model nude mice were divided into control group, model group (received gavage with saline),Xiaotan Sanjie Decoction group (received garage withXiaotan Sanjie Decoction) and Tegafur group (received gavage with Tegafur), 10 mice in each group. Mice in the control group were under normal diet, without medicine intervention. After 6 weeks of treatment intervention, tumor weight was detected, inhibitory rate was calculated, the ultrastructural changes of gastric cancer cells were detected through transmission electron microscopy.Results The tumor weight inXiaotan Sanjie Decoction group was significantly lower than that in control group and model group (P<0.05,P<0.01). The tumor inhibition rate was 46.2%. Under the electron microscope, MKN-45 gastric cancer cells strain changed to typical apoptosis.ConclusionXiaotan Sanjie Decoction can lead to apoptosis effects on MKN-45 human gastric cancer orthotopic xenografts. All evidences indicate that inducing apoptosis may be one of the most important mechanisms ofXiaotan Sanjie Decoction in treating gastric cancer.
4.Effects of Xiaotan Jieyu Recipe on behaviors of tumor-bearing rats with chronic mild stress and the mechanism.
Lijuan XIU ; Pinkang WEI ; Huiming LIN ; Bin PANG
Journal of Integrative Medicine 2010;8(2):138-44
To investigate the effects of unpredictable chronic mild stress and Xiaotan Jieyu Recipe (XTJYR), a compound traditional Chinese herbal medicine, on the behaviors of Walker 256 tumor-bearing rats and to explore the mechanism.
6.Discussion on Academic Ideas of WEI Pin-kang in Treating Gastric Carcinoma Based on the Phlegm Theory
Ying ZHAO ; Lijuan XIU ; Xiaowei WANG ; Xuan LIU ; Ye LU ; Xiaoqiang YUE
Chinese Journal of Information on Traditional Chinese Medicine 2017;24(5):106-109
Professor WEI Pin-kang has engaged in prevention and treatment of gastrointestinal tumors through intrgrated traditional Chinese and Western medicine for more than forty years. According to the characteristics of the gastric cancer development and using the philosophy thinking of TCM comparative states, combined with the ancient theory of phlegm syndrome in TCM, Professor WEI Pin-kang put foward his original theory that is the concept of phlegm differentiation of gastric cancer theory, and built the theory of the stomach sputum pollution, which can renovate the body's environment, eradicating the cause and improving the quality of life for cancer patients.
7.Multivariate Analysis on TCM Syndromes of Gastric Cancer
Dazhi SUN ; Lijuan XIU ; Jun SHI ; Jianpeng JIAO ; Long LIU ; Xiaoqiang YUE
Chinese Journal of Information on Traditional Chinese Medicine 2016;23(10):16-20
Objective To explore the composition and distribution law of TCM syndromes in gastric cancer. Methods Based on the multicenter and large-sample clinical epidemiological investigation, the four methods of diagnosis of and clinical materials of 767 cases of gastric cancer were collected, and the database of TCM syndromes in gastric cancer was establish. Factor analysis and clustering analysis were used to explore composition and distribution law of TCM syndromes in gastric cancer. Results Gastric cancer symptoms mainly included fatigue, weight loss, dizziness and other non-specific systemic manifestation, and epigastria discomfort, belching, fullness or eating just a little swelling, pain, acid regurgitation, loss of appetite and other local manifestations. At the same time, the red tongue, moss greasy, pulse fine or string and other traditional Chinese medicine signs were also included. Eliminating 92 cases with too little symptoms, 675 cases were under multivariate analyzed. 25 syndrome variables were selected after initial factor analysis, again through factor analysis 10 factors with eigenvalues more than 1.0 were obtained and the cumulative contribution rate was 60.5%. Through further K-means clustering analysis on 10 common factor integrals, it was found that when all the cases were clustered into 7 classes consistent with clinical practice most. The numbers of patients with the 1-7 type were 165, 82, 90, 79, 88, 95 and 76, respectively. Analysis on the main factors in the combination of professional knowledge, the 7 types were named as the syndrome of spleen and stomach qi stagnation (24.44%), the syndrome of qi and blood deficiency (12.15%), the syndrome of spleen deficiency (13.33%), the syndrome of blood stasis (11.70%), the syndrome of phlegm dampness (13.04%), the syndrome of deficiency cold of spleen and stomach (14.07%), the syndrome of incoordination between liver/gallbladder and stomach (11.41%) respectively. Conclusion The results of multivariate analysis suggests that the location of gastric cancer is in the stomach, and closely related to spleen, liver and gallbladder. The general pathogenesis is asthenia in origin and asthenia in superficiality. The deficiency lies in qi, blood and yang qi, while asthenia superficiality owes to stagnation of qi, phlegm and blood stasis.
8.Effects of Xiaotan Sanjie Decoction on expressions of interleukin-8 and its receptors in gastric tumor xenografts and gastric tissue adjacent to the tumor in mice.
Dawei JU ; Pinkang WEI ; Huiming LIN ; Dazhi SUN ; Shan YU ; Lijuan XIU
Journal of Integrative Medicine 2010;8(1):74-9
To explore the mechanisms of Xiaotan Sanjie Decoction (XTSJD), a compound traditional Chinese herbal medicine, in inhibiting the tumor growth and preventing recurrence by testing the protein expressions of interleukin-8 (IL-8) and its receptors chemokine receptor 1 (CXCR1) and chemokine receptor 2 (CXCR2) in gastric tumor xenografts and gastric tissue adjacent to the tumor in mice.
9.Effects of computerized cognitive remediation therapy combined with social skill training on the negative symptoms of schizophrenia
Xianli FAN ; Zhenning WU ; Kewen WU ; Yutao ZHANG ; Lijuan BAI ; Yan WANG ; Dongmei YAN ; Xiu WU ; Huifang BAI ; Zhirui LI
Chinese Journal of Primary Medicine and Pharmacy 2023;30(2):235-239
Objective:To investigate the effects of computerized cognitive remediation therapy (CCRT) combined with social skill training on the improvement of negative symptoms of schizophrenia.Methods:A total of 102 schizophrenic patients who received treatment in Shanxi Province Social Welfare Kangning Psychiatry Hospital from March 2019 to June 2021 were included in this study. They were randomly divided into an intervention group and a control group ( n = 51/group). During the intervention process, because of the reasons such as midway discharge, only 93 patients were included in the final analysis, consisting of 47 patients in the intervention group and 46 patients in the control group. All patients received social skills training. Patients in the intervention group received 8-week CCRT. The Positive and Negative Syndrome Scale and Social Skills Checklist were used to evaluate curative effect in the two groups. Results:After treatment, total score of the Positive and Negative Syndrome Scale and the score of negative symptoms in the intervention group were (46.36 ± 9.33) points and (11.15 ± 3.53) points, respectively, which were significantly lower than (51.06 ± 10.26) points and (16.42 ± 4.75) points in the control group ( t = 2.07, 5.41, both P < 0.05). The total score of Social Skills Checklist, conflict resolution ability score and relationship building ability score in the intervention group were (16.05 ± 6.85) points, (3.36 ± 1.65) points and (3.14 ± 1.83) points, respectively, which were significantly lower than (21.08 ± 8.24) points, (5.92 ± 2.35) points and (6.75 ± 2.51) points, respectively ( t = 2.87, 5.34, 7.00, all P < 0.01). Conclusion:CCRT combined with social skill training can effectively improve the negative symptoms of patients with schizophrenia.
10. HER2 status in gastric adenocarcinoma of Chinese: a multicenter study of 40 842 patients
Dan HUANG ; Zengshan LI ; Xiangshan FAN ; Hongmei WU ; Jianping LIU ; Wenyong SUN ; Shanshan LI ; Yinyong HOU ; Xiu NIE ; Jun LI ; Rong QIN ; Lingchuan GUO ; Jinghong XU ; Huizhong ZHANG ; Miaomiao SUN ; Qiaonan GUO ; Yinghong YANG ; Yanhui LIU ; Yu QIN ; Lijuan ZHANG ; Jinghe LI ; Zhihong ZHANG ; Peng GAO ; Yujun LI ; Weiqi SHENG
Chinese Journal of Pathology 2018;47(11):822-826
Objective:
To investigation HER2 status in gastric adenocarcinoma of Chinese and contributing factors to the HER2 expression.
Methods:
HER2 status of 40 842 gastric adenocarcinomas and clinical data were retrospectively collected from 23 hospitals dated from 2013 to 2016. The association between HER2 positivity and clinicopathologic features was analyzed.
Results:
Of the 40 842 patients the median age was 62 years, the male female ratio was 2.6∶1.0. The rate of HER2 positivity was 8.8% (3 577/40 842). HER2 expression was related to the tissue type, tumor location, Lauren classification and tumor differentiation (