In the paper,in vitro degradation of DL polylactic acid (PDLLA) film was studied.Regulation and tendency of degradation were showed by molecular weight regulator and monomer ration mass lossing.Degradation mechanism was discussed in light.It was thought that degradation of PDLLA in vitro was a simple hydrolysis reaction.The hydrolysis reaction was self catalytic reaction caused by terminal carboxyl group.

Objective To evaluate the effect of multimodal warming regimen on the development of intraoperative hypothermia in the patients undergoing precise hepatectomy.Methods Sixty patients of both sexes,aged 28-64 yr,weighing 44-89 kg,of American Society of Anesthesiologists physical status Ⅰ or Ⅱ (Child-Pugh A),undergoing precise hepatectomy,were equally and randomly assigned into control group (group C) and muhi-model warming group (group M) using a random number table.A bed sheet was covered on the body exposed,and the abdominal cavity was washed using the room-temperature peritoneal layage fluid in group C.In group M,after admission to the operating room,the room temperature was raised to 25-26 ℃,the mattress was prewarmed using the medical heating blanket,the temperature was maintained at 40 ℃ during operation,the lower body was simultaneously covered using the forced-air warming system,and the temperature was maintained at 37-39 ℃;the solution used for infusion was warmed to 37 ℃ before anesthesia;the incisional area was washed with 0.9％ sodium chloride injection which was prewarmed to 37 ℃ during operation.The development of hypothermia,hypotension and respiratory depression was recorded during operation.Before induction of anesthesia,at 1 h after anesthesia,at the end of operation,and at 5 min before discharge from postanesthesia care unit (PACU),blood gas analysis was performed,and the pH value,base excess and lactate level were recorded.The intraoperative blood loss,emergence time,duration of PACU stay,and occurrence of shivering,agitation,nausea and vomiting were also recorded.Results Compared with group C,the incidence of intraoperative hypothermia,and shivering,agitation,nausea and vomiting in PACU were significantly decreased,the emergence time and duration of PACU stay were significantly shortened,the pH value was significantly increased at 5 min before discharge from PACU,and the base excess and lactate level were significantly decreased at the end of operation and 5 min before discharge from PACU in group M (P＜0.05 or 0.01).Conclusion Multimodal warming regimen can raise the quality of recovery from anesthesia and decrease the development of intraoperative hypothermia in the patients undergoing precise hepatectomy.

OBJECTIVETo observe the difference between the combination therapy of alpha-interferon (IFN-alpha) therapy Yixuesheng Capsule and the monotherapy of IFN-alpha in treatment of chronic hepatitis B.

METHODA total of 288 patients with HBeAg-positive chronic hepatitis B proven by liver biopsy were included in this study. During the individualized therapy, they received hypodermic injection of IFN-alpha 1b, with 5 MU x time(-1) and three times x w(-1). Of them, 125 patients received combination therapy with Yixuesheng Capsule for three months, with 1.0 g/time and three times/d; and 163 patients received only IFN-alpha 1b (the IFN-alpha monotherapy group). After the course of therapy, all patients were followed up for at least 24 months. The intention-to-treat analysis was adopted for statistic analysis.

RESULTThe two groups showed no statistical significance by gender, age, liver necroinflammation grading, liver fibrosis staging, serum ALT levels, serum HBV DNA levels and IFN-alpha therapy course. The whole course and the 24-month follow-up visit cover all of 112 patients in the combination treatment group and 141 cases in the IFN-alpha monotherapy group. The response rates of the combination treatment group and the IFN-alpha monotherapy group were 48.0% (60/125) and 35.0% (57/163) (x = 4.980, P = 0.026) at the end of treatment, respectively, 45.6% (57/125) and 33.1% (54/163) (x2 = 4.645, P =0.031) at the end of 12-month-follow-up period, respectively, and 38.4% (48/125) and 32.5% (53/163) (x2 = 1.076, P = 0.300) at the end of 24-month follow-up period, respectively.

CONCLUSIONThe combination treatment with IFN-alpha and Yixuesheng Capsule shows a slightly better sustained efficacy on HBeAg-positive chronic hepatitis B patients compared with IFN-alpha monotherapy.

Adult ; Capsules ; Combined Modality Therapy ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Follow-Up Studies ; Hepatitis B, Chronic ; drug therapy ; Humans ; Interferon-alpha ; therapeutic use ; Male ; Treatment Outcome

Objective:To explore the association between statins and colorectal cancer and provide evidence for the prevention of colorectal cancer.Methods:Literatures about statins and colorectal cancer published from January 2000 to January 2020 were retrieved from CNKI, Wanfang data, PubMed and Cochrane Library database. The literatures which met the inclusion criteria were collected, and the Newcastle-Ottawa Scale and Jadad score were used to assess the studies. Meta-analysis was performed with statistical software Revman 5.0 and Stata 12.1.Results:A total of 31 studies, involving more than 1.62 million subjects, were included in the analysis. The case-control study ( RR=0.93, 95% CI: 0.88-0.98), the cohort study ( RR=0.75, 95% CI: 0.63-0.88) and the randomized controlled trial ( RR=0.79, 95% CI: 0.65-0.97) showed moderate protective effect of statins. Using statin <5 years ( RR=0.86, 95% CI: 0.76-0.96), average daily dosage ≥34 mg ( RR=0.81, 95% CI: 0.66-0.98) and lipid-soluble statins ( RR=0.86, 95% CI: 0.74-0.99) also had preventive effect on colorectal cancer; while lovastatin ( RR=1.07, 95% CI: 1.00-1.14) increased the risk of colorectal cancer. Conclusion:Statins have protective effect on colorectal cancer.

China prospective multicenter birth cohort (Prospective Omics Health Atlas birth cohort, POHA birth cohort) study was officially launched in 2022. This study, in collaboration with 12 participating units, aims to establish a high-quality, multidimensional cohort comprising 20 000 naturally conceived families and assisted reproductive families. The study involves long-term follow-up of parents and offspring, with corresponding biological samples collected at key time points. Through multi-omics testing and analysis, the study aims to conduct multi-omics big data research across the entire maternal and infant life cycle. The goal is to identify new biomarkers for maternal and infant diseases and provide scientific evidence for risk prediction related to maternal diseases and neonatal health.