Objective To study the effect of modified Shengmal decotion treating viral myocarditis, and on the basis of syndrome differentiation, to discuss the type and period for treating VM.Methods The PubMed, Embase, the Cochrane Library, the Chinese biomedical literature database(SinoMed), China hownet(CNKI), and VIP database(VIP) were retrieved for the articles on VM treated by modified Shengmal decoction with RCT method. RevMan 5.0 software was adopted for Meta-analysis.ResultsA total of 7 articles and 495 patients were involved. The results showed the modified Shengmal decoction treatment group had statistical difference to the control group in treating VM[OR(95%CI) was 3.61 (2.11,6.16),Z=4.70,P<0.01]. Among them, the decoctions contalning milkvetch root or not had statistical difference compared to the control group[contalning milkvetch root[OR (95% CI) was 2.67 (1.29, 5.52),Z=2.64,P=0.008; not contalning milkvetch rootOR (95%CI) was 5.11 (2.30,11.38),Z=3.99,P<0.01].Conclusion Modified Shengmal decoction has certaln effects in treating VM of Qi and yin deficiency type or VM in the advanced stage showing Qi and yin deficiency. The effectiveness of adding milkvetch root in Shengmal decoction to treat VM should be further discussed, the use of milkvetch root must be based on the premise of careful syndrome differentiation.

Objective To explore effect of health management on blood lipid level and carotid artery plaque in patients with carotid artery stenosis.Methods One hundred and eighty patients with carotid artery stenosis were dived divided into health management group (90 cases) and routine treatment group (90 cases).All the patients took routine treatment, and the health management were given for 12 months continuously in health management group.The levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were tested, the carotid artery was checked by carotid artery color Doppler flow imaging before and at 6 months, 12 months after treatment.Results The levels of TC, TG, LDL-C in health management group and routine treatment group at 6 and 12 months after treatment were significantly decreased than those before the treatment , and the level of HDL-C were significantly increased (all P<0.05).There was no significant difference in the levels of TC, TG, HDL-C, LDL-C before and at 6 months between the two groups (all P>0.05).The levels of TC, TG and LDL-C at 12 months after treatment in health management group were significantly decreased than those in routine treatment group, and the level of HDL-C was significantly increased (all P<0.05).There was no significant difference in Crouse plaque integral in health management group and routine treatment group between before and at 6 months after treatment (all P>0.05).The Crouse plaque integral at 12 months after treatment in health management group and routine treatment group were significantly decreased than those before the treatment (all P<0.05).There was no significant difference in Crouse plaque integral before and at 6 months after treatment between the two groups (all P>0.05).Crouse plaque integral at 12 months after treatment in health management group was significantly decreased than that in routine treatment group (P<0.05).Conclusion Long-term health management can decreased the level of serum lipid level and inflammation, and improve the situation of carotid artery plaque.

As an effective therapeutic approach for acute ischemic stroke,endovascular interventional therapy has received increasing attention.However,a large number of revascularization clinical trials have shown that its mortality rate and the incidence of complications are higher than intravenous thrombolysis.This article reviews the perioperative complications of endovascular interventional therapy of acute ischemic stroke and thek treatment.

Endovascular interventional therapy can signifantly improve the clinical outcomes in patients with acute ischemic stroke.It has become the important therapeutic means and research focus for acute ischemic stroke.However,there are many factors affecting its efficacy.This article reviews the factors affecting the treatment effect of endovascular interventional therapy of acute ischemic stroke.

Objective To investigate the effect of health education and behavioral intervention on the self-perceived burden of patients with gastrointestinal malignant tumor at end-stage.Methods From March 2012 to April 2013,70 patients with gastrointestinal malignant tumor whose lifetime was estimated to be within 6 months were extracted from five general hospitals in Tangshan.70 patients were randomly divided into the intervention group and the control group with 35 cases in each group.The two groups samely received routine nursing care,while the intervention group was given health education and behavioral intervention.Both groups were evaluated by SPBS-CP before and after intervention.Results The scores of the intervention group after intervention were lower than before intervention and the control group,which were reflected in 3 dimensions such as care burden,psychological and emotional burden and treatment burden.Conclusions Health education and behavioral intervention can effectively relieve self-perceived burden of patients with gastrointestinal malignant tumor at end-stage.

To explore the causes and treatment of arrhythmia during the peri-operative period of thoracic surgery, 566 patients undergoing pulmonary surgery were included for a retrospective analysis. Among them, 121 patients were complicated by arrhythmia. With timely treatment, the arrhythmia was controlled in all patients. The causes of arrhythmia after pulmonary surgery were old age, heart and lung diseases, abnormal ECG before operation, and long operation time.

Objective To summarize and discuss the therapeutic strategies of mechanical ventilation for severe thoracic trauma complicated by acute respiratory distress syndrome (ARDS). Methods Ninely-four patients with severe thoracic trauma complicated by ARDS, in whom mechanical ventilation were instituted and multiple methods in addition to routine treatment, were analysed. Results Eight of them died, with a total mortality of 8.5%. After Jan. 1995, by using small tidal volume mechanical ventilation, the use of mechanical ventilation was maintained for 6.8?2.2 days(P

Objective Cellular response to estradiol is mediated both by estrogen receptor (ER) binding to estrogen response element (ERE) and by non-nuclear actions like activation of signal transduction pathways such as mitogen activated protein kinase (MAPK) pathway. However, the signal transduction of estrogen involving phosphatidylinositol 3-kinase-protein kinase B (PI3K -PKB) is not clear in endometrial carcinoma. Our purpose was to study if PI3K-PKB signaling pathway could be activated rapidly by 17?-E 2 through non-nuclear action and also, whether PI3K inhibitor, LY294002, could inhibit such non-nuclear action of 17?-E 2 in endometrial carcinoma cell line Ishikawa. Methods Levels of phosphorylated PKB(Ser473 site, p-PKB) and total PKB were examined by western blotting in Ishikawa cells after stimulation with 17?-E 2 at 1?10 -6 mol/L for different time periods and at varied doses for 30 min. Optimal time and appropriate dose for 17?-E 2 to activate PKB in Ishikawa cells were observed. Inhibitory effect of LY294002 on activation of PKB induced by 17?-E 2 was also studied. p-PKB/PKB ratio was used to indicate levels of activation of PKB. Results p-PKB/PKB at 15 min (0.533?0.029) was significantly higher than the control (0.361?0.029, P 0.05, 0.05,

Objective To estimate the immune function changes of zonisamide treatment as a new antiepileptic drug monotherapy on epileptic children.Methods Forty children with epilepsy (25 girls and 15 boys,aged from 1 to 6 years old) were enrolled in the Children' s Hospital of Hebei Province as our subjects and they were followed 3 and 6 months after treatment.The venous blood sample was collected respectively from the children on empty stomach.Applying automatic biochemical analyzer to detect serum immunoglobulin.IgG,IgA,IgM through immune turbidimetry methods.While CD3,CD4,CD8 were detected through the application of flow cytometry.Results Compared with the healthy control group,IgA,IgG,CD8 levels increased and the level of CD3,CD4 decreased in epileptic children and there were significant differences (F=160.94,262.66,539.09,634.36,164.27;P＜0.05).The level of IgM between epilepsy group and control group did not showed difference (P＞0.05).After 3 months and 6 months treatment of zonisamide,the level of IgA,IgG,CD8 were decreased,while CD3,CD4 levels increased than those in epilepsy group before treatment (P＜ 0.05).Conclusion Zonisamide may play a role of the antiepileptic mechanism by improving children' s immune function.

Objective To observe the effect of compound rehmannia on SOD and ATP enzyme in the brain of SAM-P/8 dementia mice and the change of apoptosis neuron cells.Methods SAM-P/8 mice were divided randomly into three groups:experimental group,treatment group and model group.Mice in experimental group were lavaged by compound rehmannia(2ml/day,individual).Mice in treatment group were lavaged by donepezil hydrochloride(400mg/kg,individual),and mice in normal group and model contrast group were lavaged by equal sodium chloride.After 3 weeks,we observed mice′s behavior in every group and investigated the changes of SOD,Na+-K+-ATP enzyme by immunohistochemistry and investigated the changes of apoptosis cells peak by FCM.Results Compound rehmannia could improve learning and memory ability of the SAM-P/8 mice,strengthen SOD,Na+-K+-ATP activity and reduce apoptosis neurons in brain.Conclusion Compound rehmannia can significantly improve the Alzheimer's mice learning and memory ability,strengthen the energy of brain cells,and increase resistance to free radical antioxidant capacity,reduce the neuron apoptosis and has a good relatively protection and care to SAM-P/8 mice brain neurons.