1.Nursing of children dermatomyositis complicated with interstitial pneumonia
Modern Clinical Nursing 2013;(12):29-31,32
Objectives To summarize the experience of nursing care to children with dermatomyositis complicated with interstitial pneumonia.Methods The nursing histories of 11 cases of children dermatomyositis complicated with interstitial pneumonia were retrospectively looked into for summarizing the nursing measures.Results The diseases were both effectively controlled in all the children,who were given maintenance therapy by oral taking of hormone after discharge.Conclusion Such nursing measures as close observation of disease,enhanced nursing and first aid of respiratory failure,nursing of infection and secondary infection,care after mesenchymal stem cells transplantation,strengthened disinfection and isolation,are of significance for controlling the disease.
2.The relationship between homocysteine, folate, vitamin B12, lipids and carotid artery atherosclerosis in older patients
Lihua ZHU ; Yan BI ; Yunyun QI
Chinese Journal of Laboratory Medicine 2001;24(2):94-97
Objectives To investigate the relationship between homocysteine (Hcy), folic acid, vitamin B12(VitB12),lipids and the carotid artery atherosclerosis(CAAs) and the significance of their levels in predicting cardiac and cerebral vascular events of older patients. Methods Both sides of the common carotid artery and internal carotid artery were measured by B-mode ultrasound in 74 examinees in A, B, C, and D groups and a control group. With fasting serum, cholesterol, triglyceriade, apolipoprotein AI(Apo AI), apolipoprotein B (Apo B), lipoprotein (a) [Lp(a)], creatinine, glucose, folic acid, Vit B12 and Hcy were detected. Results When carotid artery atherosclerosis became severer, serum Hcy was higher. The levels of the control and A, B, C, D groups were (10.2±3.6) μmol/L, (11.5±4.4) μmol/L, (17.9±4.5) μmol/L, (24.7±10.3) μmol/L, and (41.4±22.3) μmol/L respectively. SNK test showed a significant difference between D and other groups (P>0.05). Folic acid and Vit B12 were negatively correlated with the severity of carotid artery atherosclerosis, but only A and D groups showed statistical significance. Spearman correlation coefficient showed that serum Hcy had significant negative correlation with folic acid and Apo AI(P=0.035 and P=0.000).Multiple linear regression analysis between CAAs and various risk factors showed Apo AI had negative correlation, but Apo B, Lp(a) and Hcy had positive correlation with CAAs, especially Hcy(P=0.009).Conclusion Hyperhomocysteinaemia is an important risk factor of artery atherosclerosis and the degree of CAAs is highly correlated with Hcy concentration. Hcy, Apo AⅠ,Apo B, Lp(a) are sensitive and reliable indexes for evaluating and predicting CAAs.
3.The applied analysis of brain CT and cerebrospinal fluid examination in the diagnosis and treatment of viral encephalitis in children
Lihua YUAN ; Yingying ZHANG ; Zikun QI
China Medical Equipment 2016;13(5):70-71,72
Objective:To sum up the characteristics of cerebrospinal fluid and brain CT findings of viral encephalitis in children, and provide guidance for clinical diagnosis and treatment of viral encephalitis.Methods: 117 cases of viral encephalitis were selected in our hospital and the results were analyzed by statistical analysis of cerebrospinal fluid and CT in children with viral encephalitis in order to compare the results of cerebrospinal fluid examination and CT examination.Results:Cerebrospinal fluid examination showed that the increased intracranial pressure were 52.14%(61/117), protein>0.5 g/L are 36.75%(43/117), elevated white blood cell levels were 57.26%(67/117), the neutrophils increased 33.33% (39/117), lymphocytes increased 31.62%(37/117), and the sugar concentration <3.3 mol/L are 14.53% (17/117). Head CT in the diagnosis of abnormalities in children were 98 cases, in which 21 were mild abnormal, 57 were moderately abnormal and 20 cases were severe abnormalities. Abnormal cerebrospinal fluid diagnosis rate of 94.02% was significantly higher than the rate of CT abnormalities 83.76% and the difference was statistically significant (x2=6.231,P<0.05).Conclusion: The abnormal rates of CT examination in the diagnosis of viral encephalitis were higher in patients with viral encephalitis. The combination of the two examinations could be more comprehensive than that of the patients with the disease and focus. It could be benefit for clinical treatment.
4.The Therapeutic Effect of Allergic Rhinitis by Different Acupoints Application Therapy for Wintertime Diseases in Summer Treatment
Kaiming QI ; Zhengyang ZHU ; Lihua XUAN
Journal of Zhejiang Chinese Medical University 2017;41(5):421-424
[Objective] To observe the effect of different acupoint application therapies :a summer treatment for the winter disease on allergic rhinitis ,and compare the relationship between the different acupoints and therapeutic effect. [Methods ] The 81 cases of allergic rhinitis who met inclusion criteria were divided into 12 acupoint group and 6 acupoint group. The time of application was in first ten-day period of the hot season. The duration of application was 2h. The days later, namely in the second ten-day period of the hot season, and twenty days later, in the third ten-day period of the hot season, the application was repeated respectively. Before treatment and half year after the treatment, the score of quality of life, symptoms of allergic rhinitis were observed to compare the relationship between the different acupoints and therapeutic effect. [Results] The effective rate was higher in 12 acupoints group than 6 acupoints group. After treatment, the score of quality of life, symptoms of allergic rhinitis were significantly improved( P<0.05 or P<0.01). And the comparison of the therapeutic effect of two groups showed significant difference in statistics( P<0.01). [Conclusion] The acupoint application therapy is effective for allergic rhinitis, and the comprehensive combination of acupoint is influential on the effect.
5.Differentiation of benign and malignant lymph nodes with ADC value on diffusion MR: a Metaanalysis
Miaomiao LONG ; Lihua LIU ; Guangfeng GAO ; Lihua CHEN ; Wen SHEN ; Ji QI
Chinese Journal of Radiology 2012;46(2):152-157
Objective To summarize the diagnostic efficacy of ADC value for differentiation of benign and malignant lymph nodes on diffusion MRI with Meta-analysis. Methods Published papers on differentiation of benign and malignant lymph nodes with ADC value were searched and reviewed.Quality evaluation was performed for the eligible papers before data extraction.Test for heterogeneity was performed first,then appropriate model was selected to calculate the weighted mean difference,sensitivity,specificity,positive likelihood ratio,negative likelihood ratio,diagnostic odds ratio,pretest and posttest probability.The potential of ADC value for differentiation of benign and malignant lymph nodes was assessed qualitatively and quantitatively.Results Fifteen papers including 735 cases and 1963 lymph nodes were selected.According to Meta-regression analysis,subgroup analysis and robust analysis,two studies with benign lymph nodes in patients with benign lesion and one study using chemical shift saturation technique were excluded because of their impact on the robustness of the pooled results. The weighted mean difference (WMD) between malignant and benign lymph nodes was -0.355 × 10-3mm2/s[95% confidence interval (CI):-0.423 ×10-3- -0.288 × 10-3 mm2/s].Although the cutoff of ADC value for differentiation in each study was different,the diagnostic efficacy was stable,the pooled sensitivity,specificity,positive likelihood ratio,negative likelihood ratio,diagnostic odds ratio and area under summarized receiver operator's curve were 0.87 (95% CI:0.79-0.92),0.87 (95% CI:0.82-0.90),6.5 (95% CI:4.7-9.2),0.15 (95% CI:0.09-0.25 ),43 ( 95% CI:21-87 ),0.93 ( 95 % CI:0.90-0.95 ).The posttest malignancy probability of benign lymph node indicated by ADC was 6%,while that of malignant lymph node was 72%.Conclusion The ADC value can be used to differentiate benign and malignant lymph nodes with good sensitivity and specificity noninvasively.
6.Study on morphology and function of mitral valve leaflets and mitral annulus in patients with mild mitral regurgitation by real-time three-dimensional echocardiography
Lihua JING ; Yanhong LI ; Yuming MU ; Qi TANG ; Zhisheng WU
Chinese Journal of Ultrasonography 2012;21(2):112-115
Objective To measure the parameters of mitral valve leaflets and mitral annulus in patientswithmildmitralregurgitation( MR )byreal timethree-dimensionaltransesophagealechocardiography (RT-3D-TEE),and explored the mechanism of MR.MethodsFifty-seven MR subjects were selected and twenty-eight subjects without mitral regurgitation were served as control group,all subjects were examined by RT-3D-TEE and acquired image,mitral valve quantification (MVQ) software was used for post-processing.Mitral annulus parameters (H/DAIPm,E2D,θAv-Mv,mitral annulus θnpa) and mitral valve leaflets parameters(A3DE,L2DAIPm,VA1-3tentVp1-3tentVtentHtentθnpa ) at the end of systolic were measured.The results of two groups were compared,and the most affected parameters to mild mitralregurgitation were selected.Results Compared with control group,VA3tent was decreased,mitral annulus θnpa and L2DAIPm increased,and the mitral valve leaflets θnpa was independently correlation factor of mild mitral regurgitation.ConclusionsThe mitral annulus geometry to flat in subjects with mild MR,the mitral valve local area is increased in subjects with mild MR,the mitral valve leaflets θnpa is independently correlation factor of mild mitral regurgitation.
7.Effect of EDTA combined with ciprofloxacin on Pseudomonas aeruginose biofilm infection in guineapig
Yayin LIN ; Jialin YU ; Qi LU ; Lihua LIN
Chinese Journal of Microbiology and Immunology 2011;31(10):912-915
Objective To investigate the effect of EDTA combined with ciprofloxacin on Pseudomonas aeruginose biofilm in vivo.Methods Pseudomonas aeruginosa was inhaled into the lung of guinea pigs and colonized,formed biofilm.After 7 days,the model was treated with ciprofloxacin,EDTA alone,or a combination of both for 7 days.The number of colony in the lungs is measured by agar plate.The pathological change of the lung is observed by hematoxylin and eosin (HE) staining and scanning electron microscope.Results EDTA combined with ciprofloxacin make the number of bacteria in the lungs reduced from l05 CFU/g to 10 CFU/g(t =24.67,P<0.05),the lung lesion was less-sever histophathologically.Conclusion The combination of EDTA with ciprofloxacin has significant activity to remove mucoid PA biofilm in vivo.
8.Gadolinium-enhanced MR imaging of epiphyseal and metaphyseal marrow in normal piglets.
Xiaoming, LI ; Renfa, WANG ; Jianpin, QI ; Lihua, TANG
Journal of Huazhong University of Science and Technology (Medical Sciences) 2005;25(4):461-3
The purpose of this study is to define the appearance of normal epiphyseal and metaphyseal marrow and normal changes of marrow due to fatty conversion on Gadolinium (Gd)-enhanced MR Imaging. Unenhanced and enhanced T1-weighted MR imaging were performed in proximal and distal femoral ends of 8 healthy piglets at the ages of 2, 4, 6 and 8 weeks, respectively. The changes with age in signal intensity and enhancement ratio of the epiphyseal and metaphyseal marrow with age were examined. The correlation of MRI characteristics with histological findings was studied. Our study showed that marrow of the metaphysis and of periphery of the 2nd ossification center were well vascularized hematopoietic marrow and had great enhancements. The enhancement ratio of metaphysis was greater than that of epiphyseal marrow and both enhancement ratios degraded gradually with age. The central regions of the epiphyseal ossification center and of the diaphysis were of fatty marrow and had little enhancement. It is concluded that on Gd-enhanced MR imaging the hematopoietic marrow of metaphysis and of periphery of the 2nd ossification center had greater enhancement than that of fatty marrow of central region of the 2nd ossification center. All of their enhancements decreased gradually with age.
Epiphyses/*anatomy & histology
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Femur/anatomy & histology
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Femur/*growth & development
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Gadolinium/*diagnostic use
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Growth Plate/*anatomy & histology
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Growth Plate/blood supply
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Growth Plate/growth & development
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Image Enhancement
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Magnetic Resonance Imaging
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Swine
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Swine, Miniature
9.Chromosomal and Subcellular Localization and Expression of Cell Cycle-related Regulator DCT1
Qi LIU ; Shusen WANG ; Jinlan GAO ; Lihua CAO ; Yang LUO
Journal of China Medical University 2010;(2):105-107,111
Objective To investigate the chromosomal and subcellular localization of DOC-1R terminal 1(DCT1),and detect its expression in human tissues.Methods Chromosome localization of DCT1 was detected by radiation hybrid.pEGFP-DCT1 was constructed,and HeLa cells were transfected with the plasmid.The subcellular localization of DCT1 protein was observed by fluorescence microscope.Real-time PCR was performed for the determination of DCT1 expression level in 16 kinds of human tissues.Results DCT1 was demonstrated to localize in 5q31,and its encoding protein was detected on the nuclear membrane.Additionally,DCT1 was proved to express universally in all the 16 kinds of human tissues and it was expressed at the highest level in spleen.Conclusion DCT1 might be a regulator in cell cycle,and ubiquitously express in human tissues.
10.Effect of interventional treatment on absolute alcohol in different types of liver cancer
Xianlan LIANG ; Liying QI ; Quanqing MI ; Lihua FENG
Clinical Medicine of China 2015;31(1):39-42
Objective To investigate the effect of routine ultrasound examination and interventional treatment of absolute alcohol in different types of liver cancer.Methods Thirty cases of liver cancer patients who were treated in the 3rd People' s Hospital of Yangquan from May 2010 to May 2014 were selected as ours subjects.They were performed ultrasound exam.The ultrasound characteristic was recorded.Patients were divided into intrahepatic cholangiocarcinoma (ICC) group (11 cases),hepatocellular cholangiocarcinom (HCC) group (14cases) and mixed cholangiocarcinoma group(5 cases) based on pathology results.Nine HCC postoperative recurrence patients and 7 ICC postoperative recurrence patients were treated with absolute alcohol and the clinical effect was observed.Results There were significant differences in the three groups in terms of gender,boundary definition and tumor location (x2 =8.01,6.16,7.32 ; P < 0.05).While the distribution of ultrasound echo intensity was not statistically significant(x =3.44,P > 0.05).The effective rate of interventional treatment of absolute alcohol in HCC patients was 88.89%,and 42.86% in ICC group,and the difference was statistically significant (x2 =3.88,P < 0.05).Conclusion The ultrasound characteristics of different pathological liver cancer are different.Ethanol interventional therapy on HCC patients is significantly better than the effect of ICC patients,suggesting that ICC postoperative recurrence patients can be treated combined with other methods to help improve the effect.