1.Rapid determination of ferulic acid and identification of its structure in rhizome of Phragmites communis by GC-TOFMS
Guosheng ZHANG ; Qianrong LI ; Hao YIN ; Lihu LI
Chinese Traditional and Herbal Drugs 1994;0(03):-
Objective To make a rapid determination of ferulic acid and identification of its structure in rhizome of Phragmites communis (RPC). Methods The chemical constituents were extracted by solvent and the relative content and structure of ferulic acid in RPC were determined and identified using GC-TOFMS technique. Results By GC-TOFMS, the ferulic acid was successfully isolated from the extracts of RPC in a relative content of 5%. According to the exact masses and corresponding elemental compositions of molecular ion and eight characteristic ions, a possible fragmentation pathway of the ferulic acid molecule was proposed, by which the molecular structure was confirmed. Conclusion GC-TOFMS technique is a rapid, accurate, sensitive, and reliable method for determination of the relative content of ferulic acid in RPC and identificatiion of its structure.
2.Clinical Observation of Tiaozhong YifeiPrescription Combined with Western Therapy for Treatment of Cough Variant Asthma Remission
Shixiu LU ; Lihu YIN ; Buman LI ; Pingchao XIANG ; Erming ZHANG ; Xuejing WANG ; Yumin QU ; Yuqin ZHENG ; Peihong LIU ; Lei PANG
Chinese Journal of Information on Traditional Chinese Medicine 2017;24(7):36-39
Objective To observe the clinical efficacy ofTiaozhong YifeiPrescription combined with Western therapy for treatment of cough variant asthma (CVA) remission. Methods Totally 90 patients with CVA remission were randomly divided into TCM group, Western therapy group and TCM and Western therapy group, 30 cases in each group. TCM group was givenTiaozhong YifeiPrescription, 1 dose per day, morning and evening; Western therapy group was given salmeterol xinafoate and fluticasone propionate powder for inhalation, each 1 suction, 2 times a day, inhalation; a mixture ofTiaozhong YifeiPrescription and xinafoate and fluticasone propionate powder for inhalation was given to TCM and Western therapy group, the same as above, continuous treatment for 12 weeks. TCM syndrome score, EOS, IgE, pulmonary function and safety index were observed in the three groups before and after treatment. The recurrence rate and the number of colds after three-month treatment were observed.Results TCM syndrome scores in the three groups decreased after treatment (P<0.05). There was statistical significance between TCM group and TCM and Western therapy group after treatment (P<0.05). The total effective rate of TCM group was 96.67% (29/30), 100.00% (30/30) of Western therapy group, 76.67% (23/30) of TCM and Western therapy group, with statistical significance (P<0.05). After three-month treatment, 1, 0 and 11 cases relapsed in TCM group, TCM and Western therapy group and Western therapy group, respectively, with statistical significance (P<0.001). Compared with the Western therapy group, the number of colds in the TCM group and TCM and Western therapy group significantly decreased (P<0.05). Compared with before treatment, IgE decreased significantly (P<0.05). There was no significant difference in EOS among the three groups before and after treatment (P>0.05). After treatment, the maximum expiratory flow in TCM and Western therapy groupwas higher than that before treatment and lower than that in the Western therapy group (P<0.01), and the other lung function indexes were not statistically significant (P>0.05). 1 mild adverse reaction was found in the TCM and Western therapy, and no obvious adverse reactions were found in other groups (P<0.05).ConclusionTiaozhong Yifei Prescription has good clinical efficacy for CVA.