The sources of the indoor air pollutants are widely ranging and the kinds of pollutants are increasing.More and more attention has been paid to the adverse effects of the pollutants on human health.The current studies on the sources of the pollutants,the adverse effects on human health and the control techniques were reviewed in the present paper.

ObjectiveTo observe the clinical efficacy of acyclovir in treatment of children with herpes angina. Methods127 patients suffered from herpes angina were randomly divided into two groups of children,the treatment group,64 patients received the symptomatic treatment on the basis of such general use of acyclovir treatment. The control group 63 cases, received the same general treatment as treatment grounp and, intravenous ribavirin. clinical effect was observed. ResultsThe effective rate was 98.44％, of which 37 cases markedly effective in 26 cases, 1 case of invalid; the control group, the total effective rate was 82.54％, Narkedly effective in 24 cases, effective in 28cases,ineffective in 11 cases. Two groups had significant difference. ConclusionAcyclovir in treatment of children with herpes angina could rapidly control the disease,and the clinical recovery time and efficacy was better than ribavirin.

ObjectiveTo observe the treatment effects and importance of dinoprostone suppository in promoting cervical ripening during induction of labor for full-term pregnancy and nursing points. Methods92 cases of pregnancies in the obstetrics and gynecology department of our hospital from December 2009 to January 2011 were selected and randomly divided into the observation group and the control group with 46 cases in each group.The observation group was given dinoprostone suppository for induction of labor,while the control group was given induction of labor by pitocin.The curative effects of these two drugs in cervical ripening in labor induction were compared. ResultsThe curative effects of the observation group were obvious,the cervical score of the observation group 12 h after medication was obviously higher.than that before the treatment,and compared with the control group,there were significant differences.The labor time,the total production process and delivery time of the observation group were all obviously lower than those of the control group.The successful induction rate was 91.3％ in the observation group,which was obviously higher than 80.4％ of the control group. ConclusionsThe dinoprostone suppository is suitable for cervical mature during induction of labor for full-term pregnancy,and it is safe,controllable and has good effects.

Objective To analyze the curative effects of using different ovarian stimulation plans to treat polycystic ovarian syndrome (PCOS)infertility.Methods 90 cases with infertility of PCOS were chosen and randomly divided into the A,B and C three groups (30 cases in each group).The A group had clomiphene treatment, the B group had HMG treatment,while the C group had CC combined with HMG treatment.The single follicle growth rate,HCG day intrauterine membrane,follicles and reproductive hormone levels,OHSS and pregnancies were recorded and compared in the three groups.Results In the three groups,HCG,luteinizing hormone (LH)and estradiol (E2 ) all had statistically significant differences (F =15.467 and 210.223,all P <0.05),which in the C group LH and E2 were significantly higher than those in group A and group B (all P <0.05).In the three groups,testosterone (T)had no statistically significant differences (F =1.005,P >0.05).In the three groups,single follicle ovulation rate had statistically significant differences (χ2 =64.614,P >0.05),in which single follicle ovulation rate in group C >group A >group B.In the three groups,endometrial thickness and mature follicle number all had significant differences (t =28.80,6.44,4.63,all P <0.05).Of the three groups,OHSS incidence had statistically significant difference (χ2 =7.386,P >0.05)(group B >group C >group A).In the three groups,clinical pregnancy rate,average treatment period had significant differences (F/χ2 =6.667,6.667,all P <0.05),which the clinical pregnancy rate group C >group B >group A,and the average treatment period group B >group A >group C.In the three groups,multiple pregnancy rate and abortion rate had no statistically significant differences (χ2 =2.169,0.424,all P >0.05 ). Conclusion Using clomiphene combined with small dose of menotrophin to treat PCOS infertility has better stimulation ovulation effects,higher clinical pregnancy rate,shorter drug use cycle and higher safety,which could provide the basis for the treatment of patients with PCOS infertility.

Sleep, learning and memory are all belonging to the brain essential functions .There is a long-standing standpoint that sleep supports memory consolidation which is convinced by many experiments .Sleep has a consolidation effect on memory and can help remolding short-term memory.Hence, researchers further discuss about the reciprocal relationships between sleep and learning and memory by establishing sleep-deprivation model .The present review focuses on the changes of neurotransmitters , immediate brain harm and gene related changes in order to discuss potential mechanisms underlying the reciprocal relationship between them .

Objective To study the relation of disease classification and osteoporosis in patients with chronic obstructive pulmonary disease,and to provide a theoretical basis for secondary osteoporosis.Methods A retrospective analysis of clinical data of 126 patients with COPD from January 2012 to December 2014 was made.50 non-COPD patients were included as control group,the pulmonary function and BMD of the femoral neck,trochanter,Ward Dis-trict were detected.And according to FEV1 , all patients were divided into mild pulmonary dysfunction group ( n=31),moderate pulmonary dysfunction group (n=54) and severe pulmonary dysfunction group (n=41);the rate of osteoporosis were measured in COPD group and non-COPD group,the difference of BMD were compared in patients with different pulmonary injury.Results ( 1 ) There were 45 cases of osteoporosis in 126 patients with COPD, accounting for 35.7%, 22 cases of osteopenia, accounting for 17.5%.There were 9 cases of osteoporosis in 50 patients with non-COPD,accounting for 18%,the incidence of osteoporosis were statistically different in COPD group and non-COPD group,χ2 =5.281,P<0.05.(2)The BMD of the femoral neck in mild COPD group,moderate COPD group,severe COPD group and non-COPD group were (0.74 ±0.11) g/cm,(0.66 ±0.08) g/cm,(0.56 ± 0.05)g/cm and (0.94 ±0.10) g/cm,the BMD of trochanter were respectively (0.71 ±0.12) g/cm,(0.63 ± 0.07)g/cm,(0.56 ±0.05)g/cm and (0.95 ±0.08)g/cm,the BMD of Ward District were (0.88 ±0.14)g/cm, (0.72 ±0.10)g/cm,(0.61 ±0.07)g/cm and (0.96 ±0.09)g/cm respectively,which were statistically significant (F=7.557,6.852,7.432,all P<0.01).The BMD of the femoral neck,trochanter,Ward District in COPD group were significantly less than non-COPD,and the more severe of pulmonary dysfunction,the more decreases of bone density.(3) The FEV1% in osteoporosis group,osteopenia group,normal BMD group were respectively (59.0 ±8.7)%,(77.7 ±7.6)% and (49.4 ±15.8)%;the FVC% were (77.8 ±28.8)%,(88.9 ±38.4)%,(73.8 ± 21.1)%;the FEV1/FVC were (66.5 ±20.6)%,(59.8 ±24.2)%,(34.1 ±3.6)%(F=9.554,5.556,7.487,all P<0.01),Conclusion There were a certain correlation between BMD and lung function.Osteoporosis is one of the extrapulmonary effects in elder COPD patients.So BMD should be regularly monitored for helping for early prevention and treatment of osteoporosis and development in osteoporosis,and improving lung function and clinical efficacy.

Objective To find the best way to terminate early intrauterine pregnancy through comparative observation. Methods Through comparing the method of using disposable suction curettage tube to terminate early intrauterine pregnancy and medical abortion, and the method of induced abortion with traditional metal suction tube combined with local infiltration anesthesia, the complete abortion rate, intraoperative pain, blood loss and complications,etc were observed. Results Using disposable suction curettage tube to terminate early intrauterine pregnancy can result in no pain or less pain,with a bleeding time 1 to 6 days ,3.5 days on average ,both of which less than menstrual volume,with 100% complete abortion and no complications. Postoperative recovery time of period was 25 to 40 days,32.8 days on average. This method was better than medical abortion and induced abortion with local infiltration anesthesia. Conclusion Using disposable suction curettage tube to terminate early intrauterine pregnanncy did not need cervical dilation,and had advantage of light suction,less bleeding,no pain or less pain for pregnant women,no complications,rapid recovery,and was easy and safe to operate. It was the best way to terminate early intrauterine pregnancy.

.88%, ptosis 0.35%, disease of cornea 0.27%, cataract 0.14%, congenital glaucoma 0.05%, trauma 0.67% and 3.32% were others.The number of patients had a seasonal variation and 42.98% patient visits occured in winter and summer vacation.

Objective To evaluate phenomenons and features of transient tricuspid regurgitation.Methods 56 cases of infant suffered severe pneumonia was examined by Doppler.Results The cardiac valves of the infant suffered severe pneumonia had normal shapes and location.48 cases with transient tricuspid regurgitation was found.The rate of occurance was 83.8%.Of these cases,most of them were in light level transient tricuspid regurgitation,a few were in medium level.The features were described as below:(1)The signal of reversed bloodstream from valve to right auricular was multicoloured.The direction of regurgitation was point to auricular septal or right auricular wall.The maximum velocity of regurgitation was 1.46～2.51M/S.(2)The transient tricuspid regurgitation had the features of reversibility.The transient tricuspid regurgitation could disappear nearly along with the recovery of severe pneumonia.Only 5 cases was transformed from medium level into light level.Conclusion The Doppler examination used in infant suffered severe pneumonia with transient tricuspid regurgitation is evidently superior to tricuspid valve auscultation,and the Doppler examination can be used to differentiate with congenital cardiac diseases.It is a useful method to evaluate the state,the variation and the curative effect of the illness.

Objective To study the molecular mechanism of the toxic effect for tetracycline acting on liver using toxicological microarray.Methods Utilizing the mouse toxicological microarray and animal model of tetracycline injuring BALB/c mouse liver,both of which were established by our department,we observed the gene expression profiles in different dose groups and at different time points after tetracycline treatment,and primarily analysed the function of these differentially expressed genes using Gene Ontology Consortium analysis system and hierarchical method.Results Multiple differentially expressed genes were found,and an obvious difference in the profiles was found in those treated with high-dose and low-dose tetracycline.The differentially expressed genes of all time points in high-dose group were divided to four clusters,which respectively related to the molecular mechanism of repressed enegy metabolism,enhanced protein synthesis and degradation,impared system of resisting oxidation,signal transduction genes changing to accelerate apoptosis,repressed genes associated of drug metabolism.Conclusion The analysis using toxicological microarray can offer us many clues on molecular level for studying the mechanism of the toxic effect of tetracycline acting on liver.