1.Development of automatic temperature and thermal current detection system for physiological protection equipment of the aviator
Qiong WANG ; Junqin LI ; Zhaosheng REN ; Wei LI ; Liyong SHI ; Lihao XUE ; Yanghua OU
Chinese Medical Equipment Journal 1989;0(02):-
The apparatus introduced in this paper can be used to measure and record the realtime environmental parameters and such physical information of individual protection equipment as the temperature,thermal current and thermal insulating value.The apparatus has several advantages including high accuracy,practicability,reliability and easy to operate.
2.Determination of eotaxin, tumor necrosis factor-α and interferon-γ levels in plasma from patients with chronic urticaria treated with the combination of BCG-PSN and cetirizine
Lijun SHI ; Kang ZENG ; Lihao LI ; Haijuan WU ; Xunhui ZOU ; Xiaoxiong HUANG
Chinese Journal of Dermatology 2013;46(9):676-678
Objective To investigate the changes to eotaxin,tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in plasma from patients with chronic urticaria treated with the combination of polysaccharide nucleic acid fraction of bacillus Calmette-Guerin (BCG-PSN) and cetirizine.Methods Totally,123 patients with chronic urticaria were enrolled into this study,and classified into two groups:the combination therapy group (n =60) treated with intramuscular BCG-PSN 2 ml every other day and oral cetirizine 10 mg once daily,and the monotherapy group (n =63) treated with oral cetirizine 10 mg once daily alone.The treatment lasted 54 days.Clinical efficacy was evaluated.Venous blood samples were collected from the patients before and after the treatment,as well as from 56 healthy controls.Enzyme-linked immunosorbent assay was performed to quantify the plasma levels of eotaxin,TNF-α and IFN-γ.Results At the end of the treatment,the total response rate was significantly higher in the combination therapy group than in the monotherapy group (88.3% vs.63.4%,P < 0.05).Before the treatment,no significant differences were observed in the plasma levels of eotaxin,TNF-α or IFN-γ between the two treatment groups,whereas the patients showed higher plasma levels of eotaxin and TNF-α but lower plasma level of IFN-γ compared with the healthy controls (all P < 0.5).Both the combination therapy and monotherapy resulted in a statistical decrease in plasma eotaxin and TNF-α but an increase in plasma IFN-γ (all P > 0.05),and the absolute values of changes in the three parameters were significantly higher in the combination therapy group than in the monotherapy group (eotaxin:(13.27 ± 4.11) μg/L vs.(8.12 ± 2.58) μg/L,t =8.3654,P < 0.05; TNF-α:(12.38 ± 3.95) ng/L vs.(10.32 ± 3.41) ng/L,t =3.1005,P < 0.05; IFN-γ:(17.06 ± 5.24) μg/L vs.(12.54 ± 4.07) μg/L,t =5.3573,P < 0.05).Further more,the differences between the patients and healthy controls in the three parameters disappeared at the end of the treatment (all P > 0.05).Conclusion BCG-PSN combined with cetirizine seems superior to cetirizine alone for the treatment of chronic urticaria.
3.Male pseudohermaphroditism due to 17β-hydroxysteroid dehydrogenase 3 deficiency
Jun YANG ; Guang NING ; Lihao SUN ; Jie HONG ; Jialun CHEN ; Manyin XU ; Weiqing WANG ; Xiaoying LI
Chinese Journal of Endocrinology and Metabolism 2008;24(3):272-274
Objective To investigate the clinical and genetic characteristics in a patient with 17β-hydroxy-steroid dehydrogenase (17β-HSD) 3 deficiency, regarding its pathophysiology and pathogenesis. Methods Clinical features and laboratory data were analyzed in a pedigree of 17β-HSD3 deficiency. Blood samples from the patient and his parents were collected. HSD17B3 gene was screened for mutations by PCR and subclone sequencing. Results The patient presented with pubertal virilization and gynecomastia. The physical examination showed female external genitalia and testes in inguinal canals. The chromosome karyotype was 46, XY. Serum FSH, LH, dehydroepiandrosterone sulfate, androstenedione and 17-OH-progesterone levels were raised, whereas plasma testosterone was lowered. Sequencing analysis revealed 4 nucleotide deletion (172-175del) of HSD17B3 gene. Conclusion Virilization and gynecomastia in puberty suggest the probability of 17β-HSD deficiency. It may be verified clinically by hCG-stimulating test and confirmed by gene diagnosis.
4.Evaluation of operation ergonomics at high-temperature in the cockpit.
Yinsheng TIAN ; Jing LI ; Li DING ; Qiong WANG ; Zhaosheng REN ; Liyong SHI ; Lihao XUE
Journal of Biomedical Engineering 2011;28(4):702-707
10 male subjects participated in the environmental simulation study to evaluate the operation ergonomics at high-temperature in the cockpit. Grip strength, perception, dexterity, reaction and intelligence were measured respectively during the tests at 40 degrees C and 45 degrees C, simulating the high-temperatures in a simulation cockpit chamber. Then the data obtained were compared to the combined index of heat stress (CIHS). The average values of each item of the subjects' performance at the two different temperatures are compared. The results indicated that CIHS exceeded the heat stress safety line after 45 min at 40 degrees C, grip strength decreased by 12%, and perception increased by 2.89 times. In contrast, at 45 degrees C, CIHS exceeded the safety line after 20 min, grip strength decreased by 3.2%, and perception increased by 4.36 times. However, Finger dexterity was less affected. Reaction ability was first accelerated, and then slowed down. The error rate in the intelligence test increased to a greater extent. At the high temperatures, the minimum perception was the most affected, followed by grip strength, reaction and finger dexterity were less affected, while the intelligence did not decline, but rise.
Adult
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Aerospace Medicine
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Aircraft
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Computer Simulation
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Ergonomics
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Heat Stress Disorders
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physiopathology
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Hot Temperature
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adverse effects
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Humans
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Male
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Young Adult
5. Chronic liver disease increases with damage to intestinal barrier function
Fenfen LIANG ; Jie WANG ; Lan LI ; Yu YUAN ; Wenrui XIE ; Lihao WU ; Xingxiang HE
Chinese Journal of Hepatology 2018;26(8):612-617
Objective:
To probe into the correlation between chronic liver disease and intestinal barrier function.
Methods:
1 491 cases of hospitalized patients were enrolled, of which 741 cases were of chronic liver diseases, including 397 cases of fatty liver diseases, 230 cases of chronic hepatitis, 114 cases of liver cirrhosis, and 750 cases of non-hepatic diseases. All admitted patients’ intestinal barrier function like diamine oxidase (DAO), D-lactate, lipopolysaccharide, and biochemical indicators of liver functions were tested. According to different data, statistical analysis was done using
6.Treating Asthenopia from the Perspective of “the Liver is the Basis of Resistance to Fatigue”
Jiangwei LI ; Xiaolei YAO ; Lihao CHEN ; Yi HU ; Qinghua PENG
Journal of Traditional Chinese Medicine 2024;65(6):649-651
By exploring the theory of “the liver is the basis of resistance to fatigue”, it is believed that liver with its physiological function of storing blood and governing the free flow of qi plays an important role in the body's tole-rance to physical fatigue and mental fatigue, and it is also related to the physiological activities of eyes and tendons. The formation of asthenopia is related to the dysfunction of liver, spleen and kidney. The liver plays a key role in the occurrence and development of asthenopia. The deficiency of liver blood and liver dysfunction will cause the abnormal circulation of qi and blood, which leads to the loss of malnutrition of eyes and affects the normal physiological function of eyes. During treatment, we pay attention to nourishing the blood and soothing the liver to nourish the spirit, regulating and tonifying liver qi to stimulate the liver yang, strengthening the spleen and soothing liver to replenish qi and promoting yang, nourishing the liver and kidney to harmonize yin and yang, which are meant to restore the physiological characteristics of liver being yin in form but yang in function, so as to cure asthenopia.
7.Postoperative bracing on clinical outcomes following posterior lumbar fusion for degenerative lumbar diseases: a meta-analysis
Gengyu HAN ; Zheyu FAN ; Lihao YUE ; Da ZOU ; Zhuoran SUN ; Weishi LI
Chinese Journal of Orthopaedics 2023;43(7):445-451
Objective:To systematically evaluate whether the early use of bracing after posterior lumbar fusion has advantages in terms of the improvement of clinical outcomes such as pain, functional disability, fusion rate, and complication rate in patients with lumbar degenerative diseases.Methods:All randomized controlled trials of bracing performed after posterior lumbar fusion in patients with lumbar degenerative diseases were searched in Pubmed, Web of Science, Embase, China national knowledge infrastructure (CNKI) and Wanfang database from January 1990 to May 2022. The data extracted were authors, year of publication, nationality, subject characteristics, sample size, surgical protocol, type and time of bracing, follow-up duration, preoperative and postoperative Oswestry disability index (ODI) and visual analogue scale (VAS), postoperative fusion rate and complication rate. The Cochrane Risk of Bias tool was used to evaluate the risk of bias. The use of fix- or random-effect models was depended on the magnitude of heterogeneity. Data analysis was performed using Stata 17.0 statistical software for meta analysis.Results:A total of five randomized controlled trials were included, all in English, with a total of 362 patients (male 144, female 218). The results of meta-analysis showed that there was no statistically significant difference in the improvement of ODI scores [ MD=1.25, 95% CI(-2.39, 4.88), P=0.501]and VAS scores[ MD=0.21, 95% CI(-0.22, 0.63), P=0.340]between the brace group and the control group after operation. In terms of fusion rate, there was no significant difference between the brace group and the control group[ OR=0.59, 95% CI(0.25, 1.38), P=0.224]. In addition, there was also no significant difference in the incidence of postoperative complications between two groups[ OR=1.12, 95% CI(0.58, 2.15), P=0.735]. Conclusion:The early use of bracing after lumbar fusion has no significant advantages in improving symptoms and functional recovery, fusion rate and surgical complications. The necessity of postoperative bracing after posterior lumbar fusion requires further high-quality research to prove.
8.Clinicopathological analysis of two cases of malignant perivascular epithelioid cell tumor in the retroperitoneum and pelvic cavity and literature review
Lihao CHEN ; Kaifeng LIU ; Gaozhen HUANG ; Quanqing TANG ; Shihao LI ; Zhijian XU ; Hongwei LIU
Journal of Modern Urology 2024;29(5):445-449
【Objective】 To investigate the clinicopathological features and key points of diagnosis and treatment of malignant perivascular epithelioid cell tumor (PEComa) to increase awareness of the disease. 【Methods】 The clinicopathological data of 2 patients with malignant PEComa treated in our hospital were retrospectively analyzed, and relevant literatures were reviewed. 【Results】 Both patients were male, aged 53 and 16 years, respectively.The sites of occurrence were in the retroperitoneum and pelvis, respectively.Both tumors were resected surgically, and the diagnosis was confirmed with postoperative pathology.Under the microscope, the tumor tissue of one patient was mainly composed of smooth muscle-like cells, and that of the other patient was composed of epithelioid cells, both showing pathological mitotic images and expressing HMB45, Melan-A, SMA and CD34, no tumor recurrence or metastasis was observed during the follow-up.The literatures collected involved 15 patients with retroperitoneal or pelvic PEComa, including 3 males and 12 females, of which 9 were malignant.The clinical manifestations were abdominal pain, bloating, or lower back pain.Some cases were detected during physical examinations. 【Conclusion】 Malignant PEComa is difficult to be diagnosed before surgery and easy to be misdiagnosed.The confirmed diagnosis depends on the postoperative pathological results.The preferred treatment is complete resection of tumor.Long-term follow-up is needed.