Objective To observe the effect of morroniside on cerebral infarction volume in focal cerebral ischemia-reperfusion rat model.Methods The animal model was induced by occlusion of middle cerebral artery with suture embolus, ischemia for 30 minutes, and reperfusion for 7 days. The infarction volume was measured by 2,3,5-triphenyltetrazolium chloride(TTC) staining technique.Results Compared with sham operation group, the cerebral infarction volume ratios increased obviously in model group and in the drug-treated（90 mg/kg，270 mg/kg）groups. Compared with model group, the cerebral infarction volume ratios decreased obviously in the morroniside-treated（90 mg/kg，270 mg/kg）group,while the cerebral infarction volume ratios in vitamin E-treated（35 mg/kg）group didn't change.Conclusion Morroniside may decrease the cerebral infarction volume after cerebral ischemia-reperfusion. It possesses protective effect against cerebral ischemia-reperfusion injury.

The cerebral ischemia reperfusion injury is one of factors in aggravating brain injury, and the inflammatory response is one of the main reasons in the reperfusion injury after acute cerebral ischemia. Inflammation is modulated by many factors such as inflammatory mediators and inflammatory cells that promote brain damage from ischemia injury to reperfusion injury. This paper would review the role of inflammatory cells and mediators such as cytokines, chemotactic factors, adhesion molecules on cerebral tissue injury.