BACKGROUND: With the development of China, quality of life (QOL) is getting more and more attention, however, there are few studies on QOL, especially in Mainland China.OBJECTIVE: To observe the situation of combinative application of Functional Independence Measure (FIM) and QOL assessment in rehabilitation clinical practice.DESIGN: Case analysis.SETTING: Zhongshan Hospital of Fudan University.PARTICIPANTS: Totally 83 rehabilitation patients selected from Shanghai Zhongshan Hospital from January to December 2003,consenting to take part in the study, were divided into 4 groups: bone & joint rehabilitation(n=42), stroke rehabilitation (n=17), internal medicine (n=15), and cancer rehabilitation (n=9).METHODS: Every patient carried out functional independence assessment and quality of life measurement within 24 hours of admission. FIM was adopted for functional independence assessment which included 13 items of motor (ranged from 13 to 91 points) and 5 items of cognition (ranged from 5to 35 points), and FAQ for quality of life included making telephone call,self-care economy, shopping, using vehicle, housework, jobs, entertainment,etc. with 100 in total. The author performed all the assessment.MAIN OUTCOME MEASURES: Every patient carried out FIM and FAQ assessment after admission and discharge.RESULTS: All data of totally 83 patients entered the final analysis. [1]The average age and length of hospital stay in stroke group were higher than those in other groups (P ＜ 0.01). [2] FIM motor and cognitive scores in stroke group were higher at discharge than those at admission (5.276,3.624;6.200,5.941,P ＜ 0.01), but scores of functional activity were lower at discharge than those at admission (1.253, 1.547, P ＜ 0.01). [3]In bone joint group, the FIM cognitive scores were coincidence in general, while motor scores were higher at discharge than those at admission (6.220,5.388, P ＜ 0.01), but scores of functional activity were lower at discharge than those at admission (0.610, 0.912, P ＜ 0.01). [4] Only scores of functional activity in tumor group were lower at discharge than those at admission (0.722, 0.989, P ＜ 0.05). [5] All items in internal medicine group were coincidence in general (P ＞ 0.05).CONCLUSION: FAQ is more sensitive than FIM in rehabilitation practice, but cannot replace FIM, and should be used with FIM.

Objective To investigate the effects of recombinant human growth hormone on cancellous bone of ovariectomized rats with remarkable bone loss. Methods Six-month old Sprague-Dawley(SD) rats were used to receive low, middle and high doses of recombinant human growth hormone three months after ovariectomy. Bone mineral density and bone histomorphormetry were used to study the alteration of cancellous bone of lumbar vertebrae. Results Recombinant human growth hormone significantly increased bone mineral density and improved the cancellous bone volume and trabecular bone architectures. Conclusion Recombinant human growth hormone can restore the bone loss in ovariectomized rats and improve the trabecular bone architectures. However, its effect is dose related.

Objective To investigate the imaging findings and clinicopathological features of osteofibrous dysplasia(OFD)in tibia.Methods The imaging findings of 1 0 cases with OFD in tibia,which were confirmed by pathology and had complete clinical data were analyzed retrospectively.Results The disease occurred in children and the main clinical manifestations were anterior mass and arch deformity of calf.X-ray and CT examinations showed that the lesion distributed along the long axis of tibia and the anterior cortex was involved in 9 cases and the posterior cortex was involved in another one;the midpiece of tibia was involved in 7 cases and the lesion located at the junction area between upper third and middle third of tibia in another 3 cases;9 cases showed multilocular osteolytic lesions within the expanded cortex,manifesting as the high-density bony intervals of different thickness among a number of low-density lesions and another one presented as unilocular osteolytic lesion with sclerosis rim.Lesions manifested as multiple bubble-like intermediate or high signal intensity foci and low-signal interval bands on T2WI in 3 cases of MRI examinations.Microscopic examinations revealed that the lesion was composed of fibrous tissue and trabecular bone,fibrous tissue varied from sparse to dense and trabecular bone was surrounded by a great many osteoblasts and osteoclasts of vary number.The lesion presented as band-shaped distribution with more fibrous tissue and less trabecular bone in the central zones (corresponding to osteolytic destruction areas in radiography)and with trabecular bone gradually increasing in the peripheral zones to form abundant merged lamellar bone (corresponding to bony intervals in radiography).Conclusion OFD in tibia is characterized by the high-density bony intervals(low-signal interval bands on T2WI)of different thickness among a number of low-density lesions(multiple bubble-like intermediate or high signal intensity foci on T2WI)within anterior cortex, which reflects the pathological changes.Typical cases can be diagnosed with a variety of imaging findings and clinical features.