Objective: To investigate pathophysiological mechanism of tardive dyskinesia (TD) by comparing the level of serum prolactin ( PRL ) of schizophrenic patients with TD to that of patients without TD (TD-) and normal volunteers. Methods: To assay the level of serum PRL in normal controls (n=44), chronic schizophrenic patients with TD (n=46), and without TD (n=46) by radio-immunity assay (RIA). The TD group and TD^group were matched by age, medication,disease duration matched. AIMS (abnormal involuntary movement scale) was used to measure the severity of TD. Results: The concentration of PRL in serum in the normal group (617?358?IU/ml), patients with TD (1277?1011?IU/ml) and TD- (913?602?IU/ml) had significant difference (P0.05). Conclusion: The concentration of PRL in serum in patients with TD was increased significantly.

An introduction to the laws applicable to mental disease patients,and the employment and marriage conditions of these patients,revealing the setbacks including low employment rate,low marriage rate and high divorce rate among these people.In this regard,the paper raised the points as follows:Speed up the legislation on mental health laws by the state,enhance mental health law enforcement to protect legitimate righta of mental disease patients; implement of the Law of the Peoples Republic if China on the Protection of Disabled Persons,Regulations on the Employment of the Disabled,to protect and promote equal rights of disabled persons in employment;enhance mental health communicatioas to awake the society in their care and love for mental health and mental disease patients.