Purpose:To explore the role of terminal restric tion fragments (TRFs), telomerase activity and expression of human telomerase re verse transcriptase (hTERT) in colorectal carcinoma. Methods:The telomere length, telomerase activity and expression of hTERT were studied with Southern-blot, TRAP and immunohistochemistry, respe ctively. Results:TRFs in cancer tissue was much shorter than in the adja cent tissues and normal mucosa, and TRFs was decreased gradually along with the development in cancer stage.The expression of Telomerase in colorectal carcinoma tissue was significantly higher than that in other tissues (P

Curriculum of introduction to clinical medicine(ICM) in the University of Ottawa's Faculty of Medicine was analyzed. Characteristics of ICM course in the University of Ottawa's Faculty of Medicine were: early setting, rich in content, long duration and focusing on clinical. ICM course between Guangxi Medical University and University of Ottawa's Faculty of Medicine were compared. Taking advantages of ICM course in the University of Ottawa's Faculty of Medicine was conductive to better understanding the importance , teaching objectives and means of ICM course . The teaching quality evaluation system of ICM course would be built in the future.