1.Research Progress of Astragalus Polysaccharide in Tumor Immunotherapy
Yanan WANG ; Lianping QU ; Zhikuan ZHANG ; Yangjun CAO ; Caidong SHI ; Xiaofeng ZHANG ; Feng GAO
Chinese Journal of Modern Applied Pharmacy 2023;40(24):3452-3458
Abstract
Astragalus polysaccharides(APS), as one of the main active components of Astragali Radix, a traditional famous tonic drug in China, has good pharmacological effects in regulating immunity and anti-oxidation. In recent years, with the success of PD-1/PD-L1 inhibitors and anti-CTLA-4 drugs in cancer treatment, immunotherapy has truly become one of the main clinical anti-tumor treatment methods. Aiming at the characteristics of tumor immune escape and tumor microenvironment change, this paper explores the clinical potential of APS as an anti-tumor adjuvant drug, and summarizes the role and mechanism of APS in inhibiting tumor immune escape, regulating tumor microenvironment, and improving immune function. To summarize and analyze the immune regulation of APS on various tumors in order to provide an objective basis for APS as a clinical anti-tumor adjuvant drug.
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