Objective:To discuss effect of nicorandil on unstable angina patients With persistent Weakly positive for troponin I (TnI).Methods:A total of 111 unstable angina patients With persistent Weakly positive for TnI Were randomly divided into control group (received routine treatment,55 cases) and intervention group (received nic-orandil 5mg,3 times/d based on routine treatment,56 cases).The relief of chest pain in one Week,the recurrent hospitalization for chest pain aggravation in 3 months and the cardiac mortality rate in one year betWeen tWo groups Were observed in tWo groups. Results:Compared With control group,the relief of angina pectoris in one Week (63.6% vs. 91.1%,χ2=11.97,P=0.0005)significantly increased,re-hospitalization for chest pain aggravation in three months (56.4% vs.19.6%,χ2=15.91,P=0.0001)significantly decreased in intervention group;but cardiac mortality rate during one year betWeen tWo groups Was no significant difference (5.5% vs. 8.9%,χ2=0.50,P=0.4792).Conclusion:Nicorandil can significantly reduce the unstable angina and re-hospitalization for chest pain aggravation in patients With persistent Weakly positive for TnI,but there Was no significant difference in reducing mortality Within one year betWeen tWo groups.

Objective To investigate the effect of swallowing water test in the occurrence of aspiration pneumonia in patients with cerebral infarction. Methods One hundred and twenty?seven cases patients with cerebrovascular disease were randomly divided into two groups:swallow water group and control group,who were guided food program according to the result of swallow water test or experience. The number of two groups to use nasal feeding and the number of cases of the two groups occurred aspiration pneumonia in 3, 6 months were observed. Results The nasal feeding rate of swallow water group was higher than that of control group( 27. 6%( 21/76) vs. 11. 8%( 6/51) ,χ2=4. 590,P=0. 032) . After 3,6 months,the incidence of aspiration pneumonia of control group were higher than that of swallow water group(17. 6%(9/51) vs. 1. 3%(1/76),19. 6%(10/51) vs. 3. 9%(3/76),χ2=9. 080,6. 530,P<0. 05). Conclusion Water?swallowing test is a simple and practical method for assessment risk of aspiration pneumonia of patients with cerebral infarction,which is more effectively to reduce the risk of aspiration pneumonia than the empiric selection method of nasal feeding.

Objective: To investigate the etiologic and epidemiologic features of an infectious diarrhea outbreak in a boarding school in Fuyang city, Anhui province. Methods: Traceability hypothesis of this study was tested according to the epidemiological characteristics of the cases. Feces, anal swabs, water samples and food residues related to the patients and chefs were collected for pathogen isolation and detection. Biochemical identification, virulence gene detection, drug susceptibility test, PFGE and multilocus sequence typing were performed. Results: The incidence rate (3.41%) of different dormitory buildings within the water supply area by shallow wells was higher than that (0.98%) of the deep wells, with statistical significance (χ²=17.215, P<0.001). Sixteen strains belonged to the Shigella Sonneri family were isolated from the patient’s samples, and all carrying the ipaH gene. Seven strains belonged to sen and ial genes. Set1 gene that did not appear in all the 16 strains were highly resistant to ampicillin, tetracycline, compound xinnomine, cefazoline, cefotaxime, gentamicin, naphthidinic acid and streptomycin, including 9 strains to doxycycline. The pulse field pattern of the 16 strains of Shigella sonneri appeared the same, with the ST type as ST152. Conclusion When combined data from the etiological and epidemiological investigation, it was confirmed that Shigella sonneri was the pathogen of this outbreak, and water from the shallow wells might be responsible for the source of infection.