1.Pathogen isolation and whole-genome sequence analysis of human adenovirus type 55 outbreak on plateaus
Wenbo WANG ; Yuan LIU ; Yifan ZHOU ; Liangqi GU ; Xuelian ZHANG ; Lin ZHANG ; Maomao CHEN ; Xianjun YANG ; Ziying ZOU ; Ping GUO ; Wei QIU ; Xiaobing HU ; Quanshui FAN
Military Medical Sciences 2017;41(6):453-456
Objective To investigate the variation characteristics of adenovirus type 55 (HAdV-B55) gene on plateaus.Methods Throat swabs were collected from HAdV-B55 infected patients and used for virus isolation in HEp-2 cells.The whole-genome sequence was obtained by PCR and sequencing.HAdV-B55 gene sequence was blast with the previously reported virus.Results HAdV-B55 strains were isolated from throat swabs, which were named LS89/Tibet/2016.The whole-genome sequence was obtained and submitted to GenBank with the accession number of KY002683.No large fragment gene recombination was found between this HAdV-B55 strain and previous strains, and the sequence similarity with QS-DLL strain was 99.9%.Conclusion This study provides more information for the evolution patterns of adenovirus 55 and will contribute to the prevention and control of HAdV-B55 infection in the future.
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