Objective: To observe clinical and serologic effects of self-made Chinese drug Liangxue Baidu Decoction Granules combined with azithromycin on early syphilis. Methods: 68 cases of early syphilis were randomly divided into two groups. The treatment group (u=43) were treated by Liangxue Baidu Decoction Granules combined with azithromycin and the control group (n=23) by simple azithromycin. Their therapeutic effects were compared. Results: There were significant differences between the two groups in the returning-negative rate of TRUST 1, 3, 6, 9 and 12 months after treatment (P