Gastric cancer is the common malignant tumor of digestive tract,and liver metastasis in patients with advanced gastric carcinoma is the most common cause of death.The early diagnoisis of Liver metastasis of gastric cancer in patients with early diagnosis would help to improve the patient' s quality of life and prognosis.Briefly review the blood,imaging and pathological biopsy method in early diagnosis of liver metastasis of gastric cancer.However it is difficult for this.Researchers over the world should have more exchanges in order to develop guiding principles in the end.

The management of laryngeal cancer and hypopharyngeal cancer has fundamentally changed over the recent years. The optimum treatment protocols should pay close attention to the survival rate and function preservation. The purpose of this article we aimed to define the prevalence of intervention of laryngeal cancer and hypopharyngeal cancer, such as open operation, CO2 laser and non-invasive treatments, and measures that may facilitate standardization of such practices.

Humans ; Hypopharyngeal Neoplasms ; therapy ; Laryngeal Neoplasms ; therapy

Evidence-Based Medicine ; Humans ; Neuronavigation

Objective]The article summarizes the experience of professor Zhou Enchao in treating diabetic nephropathy . [Methods]Pro.Zhou Enchao treats diabetic nephropathy by pairing drugs; discuses the clinical experience of professor Zhou Enchao in the treatment on diabetic nephropathy from the pathogenesis,treatment,and one case. [Results]Professor Zhou Enchao believes that the disease is caused by Qiyin deficiency, mixed with wet ,Fengxie and blood stasis. Pro.Zhou Enchao treats diabetic nephropathy by pairing drugs,such as astragalus membranaceus and Chinese yam,radix rehmanniae recene and radix scrophulariae,corn stigma and loofah sponge,stiff silkworm and scorpio,salvia miltiorrhiza and earthworm. And these usually lead to good curative effect. [Conclusion]Professor Zhou's clinical experience in treating diabetic nephropathy from pairing drugs is well worth extending in clinic for it always has significant effect.

Objective · To observe the changes in peripheral blood CD14dimCD16+ monocyte count and serum C-reactive protein (CRP) level in elderly patients with chronic heart failure (CHF) and analyze the relationship between these changes and the cardiac function of patients. Methods · 42 elderly patients with CHF (the CHF group, consisting of 18 cases of NYHA cardiac function grade Ⅱ , 18 cases of NYHA cardiac function grade Ⅲ , and 6 cases of NYHA cardiac function grade Ⅳ) and 25 healthy elderly people (the control group) were enrolled. Peripheral blood CD14dimCD16+ monocyte count, serum CRP level, left ventricular ejection fraction (LVEF), and left ventricular end-diastolic diameter (LVEDD) were measured and statistical analysis was performed. Results · CD14dimCD16+ monocyte count and serum CRP level were significantly higher in the CHF group than in the control group (P<0.05). In the CHF group, the CD14dimCD16+ monocyte count, serum CRP level, and LVEDD of NYHA grade Ⅳ patients were significantly higher than those of NYHA grade Ⅱ patients, while their LVEF was remarkably lower than that of NYHA grade Ⅱ patients. The differences were statistically significant (P<0.05). Correlation analysis results showed that peripheral blood CD14dim CD16+ monocyte count and serum CRP level were positively correlated with LVEDD (r =0.37, r =0.45, P<0.05) and negatively correlated with LVEF (r =-0.56, r =-0.33, P<0.05) in the CHF group. Conclusion · The deterioration of elderly patients with CHF is associated with inflammation and the monocyte dysfunction may exist in the heart failure process. Peripheral blood CD14dim CD16+ monocyte count and serum CRP level are expected to be novel biomarkers that can reflect the severity of heart failure.

OBJECTIVE:To establish the quality standard of Jinwu jiangu capsule. METHODS:Microscopy was used to identi-fy Panax notoginseng;TLC was used to identify Paeonia lactiflora and Sinomenii Caulis;HPLC was used to determine the content of paeoniflorin. The column was ZORBAX SB-C18 with mobile phase of acetonitrile-0.1% phosphoric acid(13∶87,V/V)at a flow rate of 1.0 ml/min,detection wavelength was 230 nm,column temperature was 30 ℃ and injection volume was 10 μl. RESULTS:Microscopy showed P. notoginseng had obvious features;P. lactiflora and Sinomenii Caulis in preparation were well-separated with clear spots. The linear range of paeoniflorin was 0.014-1.412 μg/μl(r=0.999 2);RSDs of precision,stability and reproducibility tests were lower than 2%;recovery was 95.73%-99.48%(RSD=1.54%,n=6). CONCLUSIONS:The method is simple,accurate and reproducible,and can be used for the quality control of Jinwu jiangu capsule.

Objective To determine the serum levels of triggering receptor expressed on myeloid cells-1 (TREM-1), analyse its relationship with inflammatory factors, and explore its clinical values. Methods Serum concentrations of TREM-1, TNF-α, IL-8 and IL-1β in 19 patients with early acute pancreatitis (AP) were measured by enzyme-linked immunoadsorbent assay and the relationship among them was analyzed, and it was compared with those of 20 normal controls. Results In patients with early AP, serum levels of TNF-α, IL-8, IL-1β and TREM-1 were (52.26±12.98) pg/ml, (20.18±9.81) pg/ml, (35.57 ± 13.34) pg/ml and (83.09 ± 32.49) pg/ml;while they were (18.69 ± 6.42) pg/ml, (9.81 ± 4.80) pg/ml, (14.94 ± 5.16) pg/ml and (8.44±8.42) pg/ml in control group, and there was significant difference between the two groups (P < 0.01). TREM-1 was positively correlated with other inflammatory factors in patients with early AP, and it had a sensitivity of 77.8%, specificity of 70.0% for prognosis prediction, which was better than TNF-α, IL-8, IL-1β. Conclusions TREM-1 may influence the leveLs of inflammatory factors and to some extent predict the early prognosis of AP.

Objective To discuss the influence of follow-up intervention on disease control of pa-tients with diabetes mellitus. Methods 160 patients who received education about diabetes mellitus were divided into the intervention group and the control group randomly according to the date of dis-charge with 80 patients in each group.The intervention group was given regular follow-up visit (including telephone fol-low-up) which lasted 12 months.The control group received no regular foUow-up.The health behavior,self-management ability and alleviation state of cognition level,fast glucose, glycosylated hemoglobin were com-pared after intervention between the two groups by t test andχ2 test. Results The health behavior,self-management ability and alleviation state of cognition level in the intervention group were better than those of the control group.The blood glucose 6 and 12 months after discharge was higher than that at the time of dis-charge and that of the intervention group at the same time point.The glyeosylated hemoglobin of the interven-tion group was reduced 6 and 12 months after discharge compared with that at the time of dis-charge. Conclusions Out-of-hospital follow-up is an effective method to extend hospital health educa-tion to patients' home. It can instruct and supervise the patients to assume the responsibility of subsequent targets control,so it plays a positive role in the blood glucose control,improvement of life quality and promo-tion of psychological and physical health.It is worthy of wide popularization.

Objective To investigate the effect of electroacupuncture at bilateral points Quchi on blood pressure variability in hypertensive disease patients.Methods One hundred and two patients were randomly allocated to treatment and control groups, 51 cases each. Methods The treatment group received electroacupuncture at bilateral points Quchi and the control group, no treatment as a blank control. Twenty-four-hour dynamic blood pressure and blood pressure variability were observed in the two groups of patients. Results There were statistically significant post-treatment differences in 24-hour systolic pressure standard deviation (24 hSSD), daytime systolic pressure standard deviation (dSSD) and night systolic pressure standard deviation (nSSD) between the treatment and control groups (P<0.05). There were no statistically significant post-treatment differences in 24-hour diastolic pressure standard deviation (24 hDSD), daytime diastolic pressure standard deviation (dDSD) and night diastolic pressure standard deviation (nDSD) between the treatment and control groups (P>0.05).Conclusion Electroacupuncture at bilateral points Quchi can reduce systolic pressure variability in hypertensive disease patients.