Metabolic surgery have the ideal weight loss effect,can maintain the long-term ideal weight,and its effects on blood glucose control is better than the simple medical treatment.Therefore,metabolic surgery received widespread attention in China.More and more patients undergo metabolic surgery,but the surgeons often pay attention to the operation,neglecting the use of drugs after surgery.The patients are always complicated with a lack of vitamin and metabolic syndrome,such as type 2 diabetes mellitus,hypertension,polycystic ovary,sleep apnea,cardiovascular disease.Patients have taken drugs before surgery can cause esophageal reflux,ulcer,anemia,loss of calcium and other complications,patients need to be supplied with vitamins and minerals after surgery.So more attention should be paid to the rational application of drugs after surgery,to prevent adverse reactions from improper use of drugs,and reduce the incidence of postoperative complications.

Background and purpose:Glut functioning as a vehicle for transferring glycose into cell,plays an important role in strengthening the glycometabolism process of malignant tumor.HIF-1?,a crucial transcriptional control gene in signaling cell to adapt to anaerobic microenvironment,can activate the expression of many anaerobic-responding genes which includes the expression of Glut1 gene,in order to supply energy for tumor under hypoxia.Our aim was to investigate the expression and clinical significance of Glut1 protein and HIF-1? protein as well as the correlation between them in human hepatocellular carcinoma(HCC). Methods :Immunohistochemical staining: EnVision method was used to detect the expression of Glut1 and HIF-1? in 45 cases with human hepatocellular carcinoma,and in 11 cases with normal hepatic tissue. Results :The positive expression rate of Glut1(66.7%) and HIF-1?(73.3%) in human hepatocellular carcinoma was higher than that in normal hepatic tissue(P

Objective To investigate transitional care needs of the patients with gastric carcinoma before discharging, and improve their quality of life. Methods Through questionnaire and convenience sampling, 78 gastric carcinoma patients were recruited from a cancer hospital in Beijing. A self-made questionnaire was used to investigate the transitional care needs of the patients before discharging. Results 94.9% (74/78) of patients needed transitional care. 92.3% (72/78) of patients were willing to receive transitional care either from hospital they were discharged from or community medical institutions nearby with the guidance of the hospital. The most prevalent demands of the gastric cancer patients included food、return visit、the follow-up treatment、wound and defecation. The rates were 100.0%(78/78), 100.0% (78/78), 100.0% (78/78), 92.3% (72/78), 85.9% (67/78). Conclusions Most of the gastric carcinoma patients highly demanded transitional care. We should strengthen the management of patients after discharge, so as to improve their quality of life.

Type 2 diabetes(T2DM) is the collective result of insulin resistance in both muscle and liver andβ cell function failure. Traditional pharmaceutical therapy fails in ceasing progressive decline in β cell function. Bariatric surgery has been widely accepted as an efficient measure to treat diabetes. However, the prevalent standards mainly based on body mass index can not meet the demand for promoting remission rate. Related factors should be included in prediction of post-operative remission, like end-point setting, T2DM status, biochemical index, and operative method etc. The combination of these factors can be used to benefit more patients with diabetes.

Phase-contrast magnetic resonance imaging (PC-MRI) is a valuable and noninvasive method for evaluating hemodynamics and assessing the severity of disease processes involving the cardiovascular system. The basical principles, influential factors and the applications of PC-MRI in the assessment of cardiovascular diseases were reviewed in this paper.

Case based learning(CBL)is one of the teaching modes in clinic education and it is important to explore its teaching methods and qualities.This article discussed on how to use debate in CBL in neurology teaching for seven-year-program students including its organization,topic choosing,rules and specific process in order to provide references for teaching reform.

OBJECTIVE: To discuss the biosafety and biocompatibility of biomaterials. METHODS: A computer-based online search of CNKI, CBM and VIP as well as manual search were performed to collect articles about random cell control experiments and animal experiments of biological material biocompatibility published between 1990 and 2008. A total of 28 Chinese literatures were collected, and 7 were included mainly involving the cytotoxicity test methods and blood compatibility of the experimental medium, experimental grouping, experimental materials, methods of observation, experimental results, and experimental conclusion. In addition, biocompatibility of the biological material was analyzed to summarize the biocompatibility of the biological safety. RESULTS: Based on experiments of biosafety and biocompatibility of biomaterials, the cytotoxicity test and blood compatibility of various biomaterials, such as collagen, chitosan, magnetic nanoparticle, metal vascular stent, sulphurated siliastic medical grade silicon rubber, polyurethane, ceramic coatings by micro-arc oxidation, are essential for the biological safety. The experimental results have shown that the biomaterials have good biocompatibility. CONCLUSION: A variety of biological materials present good biocompatibility, including collagen, chitosan, magnetic nanoparticle, metal vascular stent, sulphurated siliastic medical grade silicon rubber, polyurethane, ceramic coatings by micro-arc oxidation, based on the evaluation criteria.

Leptin,a peptide hormone synthesized and secreted primarily by adipose tissue,plays an important role in the regulation of body weight,metabolic and endocrine responses.It has emerged recently as a protective factor in multiple organ resistance to injury.We reviewed the protective effect of leptin and its possible mechanism.

Objective · To observe the changes in peripheral blood CD14dimCD16+ monocyte count and serum C-reactive protein (CRP) level in elderly patients with chronic heart failure (CHF) and analyze the relationship between these changes and the cardiac function of patients. Methods · 42 elderly patients with CHF (the CHF group, consisting of 18 cases of NYHA cardiac function grade Ⅱ , 18 cases of NYHA cardiac function grade Ⅲ , and 6 cases of NYHA cardiac function grade Ⅳ) and 25 healthy elderly people (the control group) were enrolled. Peripheral blood CD14dimCD16+ monocyte count, serum CRP level, left ventricular ejection fraction (LVEF), and left ventricular end-diastolic diameter (LVEDD) were measured and statistical analysis was performed. Results · CD14dimCD16+ monocyte count and serum CRP level were significantly higher in the CHF group than in the control group (P<0.05). In the CHF group, the CD14dimCD16+ monocyte count, serum CRP level, and LVEDD of NYHA grade Ⅳ patients were significantly higher than those of NYHA grade Ⅱ patients, while their LVEF was remarkably lower than that of NYHA grade Ⅱ patients. The differences were statistically significant (P<0.05). Correlation analysis results showed that peripheral blood CD14dim CD16+ monocyte count and serum CRP level were positively correlated with LVEDD (r =0.37, r =0.45, P<0.05) and negatively correlated with LVEF (r =-0.56, r =-0.33, P<0.05) in the CHF group. Conclusion · The deterioration of elderly patients with CHF is associated with inflammation and the monocyte dysfunction may exist in the heart failure process. Peripheral blood CD14dim CD16+ monocyte count and serum CRP level are expected to be novel biomarkers that can reflect the severity of heart failure.