3.Therapy for moderate and advanced liver carcinoma
Journal of International Oncology 2012;39(8):612-615
Due to the latent and highly invasive characteristics of liver carcinoma,a majority of patients are frequently not diagnosed until moderate or advanced stage in the disease process,and usually complicate with cirrhosis.Only 15% -30% of the patients are eligible for radical resection.The overall survival time is about 3-4 months.Therefore,on the basis of early diagnosis and treatment of liver carcinoma,how to improve the treatment effect of the moderate and advanced liver carcinoma,ameliorate the quality of life and prolong the survival time,becomes the focuses and difficulties both at home and abroad.
4.Relationship between ECG Abnormalities and Prognosisin in Patients with Cerebrovascular Accident
Journal of Medical Research 2006;0(12):-
Objective To investigate the relationship between cerebrovascular accident and abnormal electrocardiogram. Methods The ECG abnormalities and clinical data of 314 patients with cerebrovascular accident were analyzed. Results 56.7% patients developed arrhythmia. Among them, the morbility of arrhythmia in patients with cerebral hemorrhage was higher than that of cerebral infarction ( P
5.Relationship between narcissism and entrepreneurial intention in college students
Chinese Mental Health Journal 2017;31(2):156-161
Objective:To investigate the relationship between narcissism and entrepreneurial intention and roles of achievement motive and risk aversion in college students.Methods:In this study,375 college students were selected from Henan University.Their narcissism,entrepreneurial intention,achievement motive and risk aversion were assessed with the Narcissism Scale,Entrepreneurial Intentions,The Achievement Motive Scale,and General Risk Aversion Scale.Results:The scores of overt narcissism positively predicted the scores of entrepreneurial intention (3 =0.37,P < 0.001),the predictive effect of covert narcissism on entrepreneurial intention was not significant (β =-0.05,P > 0.05).The scores of achievement motive partly mediated the relationship between the scores of overt narcissism and entrepreneurial intention (95% CI:0.06-0.22),and this mediation effect was moderated by the scores of risk aversion (β =0.09,P < 0.05).Only when the score of risk aversion was higher (above one standard deviation),achievement motive was a mediator between narcissism and entrepreneurial intention.When the score of risk aversion was lower,the mediate effect was not valid.Therefore,the moderated mediation model was confirmed.Conclusion:It suggest that the moderated mediation model is feasible,that is,achievement motive is a mediator between narcissism and entrepreneurial intention,but this mediation is moderated by risk aversion.
6.Advances in study of glucocorticoid receptor induced insulin resistance and its antagonists
Chinese Journal of Clinical Pharmacology and Therapeutics 2000;0(02):-
Glucocorticoids are among those most important hormones that maintain the energy metabolic homeostasis within body.The actions of glucocorticoids on target tissues,such as liver and adipose tissue,are not only dependent on circulating glucocorticoid levels but also on glucocorticoid receptor expression.The elevated level of circulating glucocorticoid caused by exogenous or endogenous reasons may contribute to insulin resistance and the other metabolic syndrome such as dyslipidemia,visceral obesity and hypertension.This review summarizes recent advances in the study of glucocorticoid receptor-mediated insulin resistance and its antagonists.
7.Chemical Study on the Leaves of Raisin Tree(Hovenia acerba) (Ⅰ)
Chinese Traditional and Herbal Drugs 1994;0(10):-
7 flavonoids are isolated from the leaves of Hovenia acerba Lindl. On the basis of chemical and spectralmethods (IR,1H,13 CNMR),they are ivdentified as kaempferol(Ⅱ),quercetin(Ⅱ),isoquercetin(Ⅳ),kaempferol-3-Oa-L-rhamnopyranosyl(1)-?-D-galactopyranoside(Ⅶ),kaempferol-3-O-rutinoside(Ⅶ),quercetin-3-O-?-L-rhamnopyranosyl(1→6)-?-D-galactopyanoside(Ⅹ Ⅸ),and rutin(Ⅸ),All of them are isolated for the first time from genus Hovenia.
8.The effect of HGF-mediated Skp2 down-regulation on suppression of proliferation of human hepatocellular carcinoma cells
Liang HE ; Bingyang LIU ; Hong DING ; Kui DING ; Hao ZHANG
Chinese Journal of General Surgery 2001;0(07):-
Objective To investigate the effect of hepatocyte growth factor(HGF)on the proliferation of human hepatocellualr carcinoma cells,and the mechanism of HGF-induced proliferation inhibition.Methods Human hepatocellualr carcinoma cell line HepG2 were treated with different concentrations of HGF for different time periods,and the proliferation of these cells was examined by colorimetric BrdU cell proliferation enzyme-linked immunosorbent assay.The expression of S-phase kinase associated protein 2(Skp2)was examined using Western blot and RT-PCR.Plasmids pcDNASkp2 was introduced into HepG2 cells,then the clones showing up-regulation of Skp2 were selected,and the effect of HGF on the proliferation in these clones was investigated.Results HGF inhibited the proliferation of hepatoma cells in a dose and time dependent manner.The expression of Skp2 was significantly suppressed by HGF.Furthermore,HGF did not suppress the proliferation of HepG2 cells transfected with Skp2.Conclusions This study suggests that HGF could inhibit HepG2 cell proliferation,and the down-regulation of Skp2 could be closely related to this suppressed proliferation.
9.The Application of the Early Slope Value of Enhancement in Differentiating BenignMusculoskeletal Masses From Malignant Ones
Qingguo DING ; Chunhong HU ; Yi DING ; Liang GUO ; Daohai XIE
Journal of Practical Radiology 1991;0(03):-
Objective To investigate the diagnostic value of the early slope value of enhancement in differentiating benign from malignant musculoskeletal masses.Methods Dynamic contrast-enhanced gradient-recalled acquisition in the steady state imaging(GRASS) was performed to evaluate 36 musculoskeletal masses(18 malignant,18 benign).The difference of the early slope value of enhancement was analysed and compared between benign lesions and malignant ones.Using ROC curve plotting obtained the best decisive threshold.Spearman rank correlation analysis was used to determine the relation between slope and microvessel density of tumor tissues.Results The average early slope value of enhancement was (4.33?2.70)% per second (range 0.97%~10.50% per second)for malignant lesions,and was (1.46?0.97)% per second(range 0.37%~3.86% per second)for benign ones.There was an apparent statistical significance between benign and malignant tumors(?