Suxiaojiuxin pill" at a dose of 2mg/ml obviously inhibited the contraction of isolated rabbit aortic stripes induced by high K+, NA, Ach, His and 5-HT. In comparison with phentolamine, the "pill" did not shift the dose-response curve of NA, but depressed maximum response in a none competititve manner. However, similar to verapamil, it shifted high K+and Ca++-free high K+ dose response curve to the right at doses of 0.2~0.4mg/ml. PEG as a solvent did not show any effect in the all tests. These results indicated that "Suxiaojiuxin pill" has a Ca++ antagonistic effect in a none competitive manner, mainly by blocking Ca++entry through the potential dependant channel though at high concentrations it may also influenced the NA activated receptor operated channel (ROC ),

AIM: To investigate the antidysmsenorrhea pharmacologic effects of Compound Yimucao Paste (Herba Leonuri, Rhizoma chuanxiong, Radix Angelicae Sinensis, Flos Carthami) METHODS: The methods of microcirculation and isolated uterus smooth muscle of rat were used. RESULTS: Compound Yimucao Paste could improve the microcirculation disturbance on the aspects of the diameter, the velocity of mice auricle microarterioles and microveins, inhibit the isolated uterus smooth muscle contraction and mouse twister induced by oxytocin. CONCLUSION:Compound Yimucao Paste has an obvious action of blood quickening and stasis transforming and inhibit the isolate and uterus smooth muscle contraction induced by oxytocin, which are contributed to its antidysmenorrhea effect.