Acute leukemia is one of the most common cancers among children.The biological mechanisms leading to leukemia have not been fully clarified until now.Experiments were improved that most patients developing acute leukemia had abnormal chromosomes,including TEL/AML-l,BCR/ABL,PML/RAR-α fusion genes,which would be potential clinical biomarkers.Many genetic polymorphisms have effect on acute lymphoblastic leukemia susceptibility,which were containing genes involved in folate metabolism pathways,cytochrome P450,glutathione-S-transferase enzymes and quinone oxidoreductase-1.As the results of the studies,alcohol,tobacco,TNF-α and IFN-γ might be risk factors to the disease.Furthermore infection and IRF-3 were reported to reduce the occurrence of acute leukemia.Finally,as more is learned about the molecular pathology,it may be possible to develop new therapeutic agents which are specifically targeted to treat childhood acute leukemia.

The medical image registration between preoperative three-dimensional (3D) scan data and intraoperative two-dimensional (2D) image is a key technology in the surgical navigation. Most previous methods need to generate 2D digitally reconstructed radiographs (DRR) images from the 3D scan volume data, then use conventional image similarity function for comparison. This procedure includes a large amount of calculation and is difficult to archive real-time processing. In this paper, with using geometric feature and image density mixed characteristics, we proposed a new similarity measure function for fast 2D-3D registration of preoperative CT and intraoperative X-ray images. This algorithm is easy to implement, and the calculation process is very short, while the resulting registration accuracy can meet the clinical use. In addition, the entire calculation process is very suitable for highly parallel numerical calculation by using the algorithm based on CUDA hardware acceleration to satisfy the requirement of real-time application in surgery.
Algorithms ; Humans ; Imaging, Three-Dimensional ; Tomography, X-Ray Computed ; X-Rays

Objective:To investigate the application value of interferon-γ release assay ( IGRA ) in immunocompromised patients with pulmonary tuberculosis. Methods:180 cases were chose including immunocompromised patients,pulmonary tuberculosis patients,immunocompromised patients with pulmonary tuberculosis and healthy volunteers to undergo IGRA in order to determine and compare the content of specific interferon-γ( IFN-γ) in plasma. At the same time, the result of immunocompromised patients with pulmonary tuberculosis was compared with tuberculin skin test (TST). Results:180 cases of the list were tested,included 40 immuno-compromised patients ( group A ) , 50 pulmonary tuberculosis patients ( group B ) , 40 immunocompromised patients with pulmonary tuberculosis patients(group C),and 50 cases in healthy control group(group D). The median of specific IFN-γ contents in the four groups were respectively 0. 112,7. 835,5. 726,0. 697 U/ml. The comparison of differences among the four groups was statistically significant (χ2=74. 046,P<0. 001). Pairwise comparisons among the four groups,and the differences between group B and group C were no significant,but specific IFN-γ content of the two groups was significantly higher than the other two groups,while the group D was higher than group A,the differences were statistically significant. The positive rate of IGRA was significantly higher than that of TST in group C(χ2=11. 314,P=0. 001). Conclusion: IGRA diagnosis in the application of immunocompromised patients with pulmonary tuberculosis was less affected by immune status and was more sensitive than TST,which can be used as auxiliary diagnosis.

Anoikis,a specific form of programmed cell death,is triggered by cell detachment from extracellular matrix or adjacent cell.Studies have found that the most kinds of tumor cells had anoikis resistance characteristic,which may inhibit pro-apoptosis protein,block anoikis inside and outside pathways,up-regulate pro-survival factor signals,and promote survival,invasion and metastasis of tumor cells in the end.The review summarized the mechanism of anoikis and the relationship between anoikis and tumor invasion and the metastasis.

Role of chronic inflammation in type 2 diabetes and obesity has been recognized in the past few years. Examples of potent inflammatory cytokines are C-reactive protein (CRP),tumor necrosis factor-?(TNF-?) ,plasminogen activator inhibitor-1 (PAI-1) and interleukin-6 (IL-6). Inflammatory processes may have important roles in the development of type 2 diabetes,obesity and insulin resistance. This article reviewed the relationship between some inflammatory cytokines and diabetes, providing references for clinical diagnosis and treatment.

Objective To study the regulative effect of angelica sinensis on cellular immune function in perioperative patients with obstructive jaundice. Methods Fourteen patients with obstructive jaundice were injected with angelica before and after operation for 14 days. The activity of IL-2 and the expression of IL-2R in lymphocytes in peripheral blood were measured, respectively. Results The activity of IL-2 and the expression of IL-2R decreased significantly in patients with obstructive jaundice (P

Objective To investigate the epidemiological characteristics of hand -foot -mouth disease (HFMD in Weihai of Shandong province,during 2015,and provide reference for HFMD control and prevention. Methods We analyzed data of HFMD cases in Weihai during 2015 by descriptive epidemiology.Results A total of 8 526 HFMD cases were reported in Weihai during this period,including 64 severe cases but no deaths.The reported morbidity was 304.57 /lakh.The vast majority of patients were 0 -5 years old,representing 89.16% of the patients. Most patients were in preschools or scattered home care environments,accounting for 59.60% and 35.74%, respectively.There were clearly more boys than girls,with a male to female ratio of 1.39:1,which was statistically significant(χ2 =15.013,P <0.001).Compared with the incidence of the national level,all districts in Weihai are with high incidence of HFMD,especially in Huancui district(584.02 /lakh).The cases mainly occurred during June, July.The clinical presentation was characterized by fever and various kinds of vesicles or papules at the hand,foot, mouth or buttocks.Conclusion HFMD is one of the serious health hazards communicable disease to the children under 5 years old in Weihai.According to HFMD epidemiology characteristic,immunization and treatment strategies of HFMD should be further improved.

Objective To study the variable number tandem repeats (VNTR) polymorphism in intron 4 of the endothelial nitric-oxide synthase (eNOS) gene and its relationship with plasma NO in pregnancy induced hypertension (PIH). Method The VNTR polymorphism in intron 4 of the eNOS genes of PIH and healthy control pregnant women were detected by PCR. The plasma level of NO~(3-)/NO~(2-) was measured by spectrophotometer, which was used as the index of NO synthesis.Data were analyzed according to the different type of genotypes and allelic gene frequency. Results The PIH group showed significant higher frequency of VNTR 4a allele and 4a/4b+4a/4a genotype than those of the control (16.00% vs 7.50%,P

OBJECTIVE:To probe into the optimum condition and dosage of activated carbon in the preparation of arilin injection.METHODS:The impacts of activated carbon of different dosage at different temperature,different storage time and different pH value of preparation on the contents of arilin injection were investigated and analyzed statistically.RESULTS:Positive correlation was found between the descending degree of the contents of arilin and the dosage of the activated carbon(P

OBJECTIVE:To study the effect of kallidinogenase on senile diabetic nephropathy.METHODS:95senile cases with diabetic nephropathy treated with the basic therapy were randomly divided into treatment group(plus kallidino?genase)and control group(plus aspirin),the proteinuria ejection level,hemorheological parameters and blood lipid level of2groups in24hours were investigated before and after treatment.RESULTS:As compared with prior treatment and the coutrol group,the proteinuria ejection level decreased significantly,the hemorheology improved and the blood lipid level decreased in the treatment group.CONCLUSION:Kallidinogenase is effective to some degree in the prevention and cure of senile diabetic nephropathy and diabetic macroangiopathy.