Objective To investigate the clinical efficiency and immune adjustment of oxymatrine capsule and acitretin in the treatment of psoriasis.Methods Eighty patients with psoriasis were randomly divided into treatment (T) and control (C) groups.The T group took orally oxymatrine one capsule (0.2g) three times a day and one acitretin (10 g) two times a day.The C group only took orally one acitretin (10 g) two times a day.The T and C groups were applied the same drug for external use.Moreover,another 40 normal volunteers were set as normal control group.The peripheral blood T cell subset CD3 +,CD4 +,CD8 +,CD4 +/CD8 + were detected in all the three groups (T,C,and normal) before and after treatment.Results The effective rate was 92.5％ in the T group,and 72.5％ in the C group with statistical significance (x2 =8.66,P ＜ 0.05).The symptom integral decline index of two groups before and after treatment has statistical significance (t =10.02,P ＜ 0.05).For the peripheral T cell subset CD3 +,CD4+,CD8 +,CD4 +/CD8 + in the T group,a significant difference was found between pretreatment and posttreatment [(57.13 ±8.14)％,(37.62 ±7.97)％,(33.01 ±2.97)％,(1.24 ±0.51)％ vs (60.09 ±11.53)％,(43.02±7.67)％,(25.63 ±4.24)％,(1.73 ±0.69)％,t =3.08 ～9.02,P ＜0.01].However,there was not any statistical significance between pretreatment and posttreatment in the C group (P ＞ 0.05).Conclusions The treatment of common psoriasis combined with oxymatrine capsule and acitretin had a good curative effect and it improved the imbalance of peripheral blood T cell subsets.

Objective To summarize the experience of nursing Moyamoya patients undergoing STA-MTA bypass.Method The histories of nursing 14 Moyamoya patients undergoing STA-MTA bypass were retrospectively analyzed to summarize the nursing experience.Result The outcomes of all the 14 patients were good.TCD or DSA showed all the anastomosed arteries were patent, and cerebral perfusion was improved.Conclusion The nursing strategies including careful observation of patients,prevention of cerebral hemorrhage and ischemia and enhanced function exercises is critical for patients’rehabilitation.

Objective:To investigate the distribution and regulation of uterine NK cells in mouse uterus during early pregnancy. Methods:Using a unique uNK cell marker,Dolichos biflorus agglutinin (DBA) lectin,to localize NK cells in uterus of normal pregnancy,delayed implantation and artificially induced decidualization. Results:DBA staining is mainly distributed in some vascular endothelial cells during embryo pre-implantation. In D5 of pregnancy after embryo implantation,NK cells were distributed in the stroma of uterine mesometrial pole,with round,immature and small lymphocyte-like cells. During D7 and D8 of pregnancy,the immunostaining results showed that uNK cells were increasingly accumulated in the mesometrial pole of implantation sites,with their morphology changing from small round cells with scattered cytoplasm to large and mature cells with heavy cytoplasmic granules. In the artificially induced decidualization model,the distribution and maturity of NK cells are similar to those of the normal pregnancy in the mouse uteri. Conclusion:The distribution and maturation of uterine NK cells are dependent of uterine decidualization in mouse early pregnancy.

Objective To review and analyze the causes of infant malnutrition and its relation with the way of feed.Methods Infant malnutrition was analysed with the emphasis on pathogeny,the onset month of the birth, its complication and clinical reflection in 63 cases.Results Infant malnutrition occurred in the case with incorrect feeding way:feeding on low protein powdered milk or cereals untimely without considering the supplementary food. Malnutrition easily brought out other kinds of disease.Conclusion It is recommended that infants younger than 5 months should be fed on breast-milk.In case of no breast-milk or short,dairy products are introduced,especially in- fant formula,with adding supplementary food timely.If not so,infant malnutrition occurs.

Object A method for the determination of daidzein, genistein, daidzin and genistin in soybean extract by RP HPLC was established Methods Zorbax SB C 18 column (4 6?15 mm, 5 ?m) was used Daidzein and genistein were separated with mobile phase Ⅰ∶methanol acetonitrile 0 1% phosphoric acid solution (30∶8∶62) Daidzin and genistin were separated with mobile phase Ⅱ∶methanol acetonitrie 0 1% phosphoric acid solution (16∶24∶60) The UV detection wavelength was 254 nm Results The average recoveries of daidzein, genistein, daidzin and genistin were 98 7%, 99 5%, 98 4%, 98 6% and the precision (RSD) were 1 4%, 0 9%, 0 9%, 1 7% (n=4) respectively Conclusion: The method was accurate, rapid and with good reproducibility

Objective: To study the protection for Compound Zigui Capsule on climacteric syndrome and the mechanism of the action, connected clinical application.Methods: Ovaritectomized rats were used as model of climacteric syndrome and to observed the effects of Compound Zigui Capsule on weight and the index of the organ of OVX rats. Bone metabolism of OVX rats was examined by single photon radionulide emission computed tomograpy.Results: Compound Zigui Capsule could antagonize an increase in body weight and atrophy of the uterus of OVX rats. The estrogenic content and phosphoric level in serum increased significantly. Results of bone metaboism examination showed that the radioactive cound/weight(c/w t) increased. Conclusion: Compound Zigui Capsule had markedly effect on improvement of endocrine disorder, increase of weight, atrophy of the sexual organs and osteopenia in OVX rats.

Objective:To observe the change of quotas such as vision acuity,fusion acuity etc after CDP-choline therapy,and evaluate comprehensively the curative effect and feasibility of it.Methods:Eighty-one amblyopic subjects were divided into 3 groups randomly:medical group with CDP-choline administration,combined group CDP-choline administration plus occlusion and meticulous work,occlusion group occlusion and meticulous work.Various kinds of side effects were carefully observed and all results were analyased statistically.Results:The appearance of the improvement of visual acuity in medical group was the earilest,but deteriorated gradually after 4 months.The combined group had improvements in all kinds of amblyopia,lasting throughout the observation period.Retina light sensitivity significantly increased in the medical group and combined group.The latency of the P 100 wave was not improved after the treatment in all of the three groups.Moreover,generalized tonic-clonic seizure was induced by CDP-choline administration in one subject.Conclusion:CDP-choline can improve the VA of amblyopic eyes,and raise the retina light sensitivity.CDP-choline treatment plus occlusion has a better curative effect.CDP-choline may induce seizure.

Objective To investigate the spatiotemporal patterns and age-related changes of expression of type Ⅰ and type Ⅳ collagen in the corneal development of Bufo raddei larvae during metamorphosis.Methods Using immunohistochemical method,type Ⅰ and Ⅳ collagen distributions were investigated in the cornea of Bufo raddei at hind-limb bud stage,hind-limb developing stage,forelimb bud stage,complete metamorphosis stage,one-year-old adult and three-year-old adult,respectively.Results The inner and outer cornea fused together into mature cornea during metamorphosis.Type Ⅰ collagen was expressed widely during the period,it existed in Bowman's membrane,Descemet's membrane,corneal stroma and endothelium,especially showing a progressive change in corneal stroma.The expression of type Ⅳ collagen was only observed in Bowman's membrane and Descemet's membrane at first,since the forelimb bud stage,it also expressed in corneal stroma and endothelium,but it didn't express the same as Type Ⅰ.Conclusion Type Ⅰ collagen has the role in the construction of the corneal stroma and its fuction in the corneal development of Bufo raddei larvae during metamorphosis.Type Ⅳ and type Ⅰ collagen expressed differently in corneal stroma showing that the construction of the corneal stroma may depend partly on the right expression proportion of different collagen type.

Objective:To explore the relationship between pulse wave velocity(PWV)and blood pressure classification in patients with hypertension in pretherapy and posttherapy.Methods:Totally,183 patients with essential hypertension were recruited in the study and their brachial-ankle PWVs were recorded by an automatic arterial stiffness measurement device.PWVs were compared between patients with varied blood pressures in pretherapy and posttherapy.Results:There was significant diference in PWV between patients with pretherapy and posttherapy[(2 080?26)cm/s vs(1 604?32)cm/s,P

OBJECTIVE:To study the protecting and therapeutic effect of compound Zigui capsule on climacteric syndrome and the mechanism of the action in rats,so that it may provide a theoretical basis for clinical treatment METHODS:The climacteric syndrome model was made by ovariectomy in rats and the effects of compound Zigui capsule on hemorheological parameters were observed RESULTS:Compound Zigui capsule could lower blood viscosity,plasma viscosity,blood reduced viscosity and red cell rigidity index It could also inhibit platelet adhesion CONCLUSION:Compound Zigui capsule has obvious preventive and therapeutic effects on rat's climacteric syndrome