Objective To investigate the effects of somatostatin combined with early enteral nutrition on inflammatory factors and intestinal permeability in patients with severe acute pancreatitis (SAP).Methods 70 patients with severe acute pancreatitis were randomly divided into the control group (35 cases) and the observation group (35 cases).The control group were given double somatostatin, the observation group were received double somatostatin combined with early enteral nutrition support.Before and after treatment in the two gorups, TNF-a and IL-1 levels were measured by ELISA;intestinal permeability index was indirect calculated by high performance liquid chromatography.Clinical curative effect and inflammatory factors and intestinal permeability were compared in the two groups.Results Seven days after treatment, the secondary infection rate, operation rate and mortality in the observation were lower than those in the control group (P<0.05);before treatment, TNF-a and IL-1 level in the two groups had no significant difference;Seven days after treatment, TNF-a and IL-1 in the observation group were lower than those in the control group (P<0.05);seven days after treatment,blood lactate levels in the observation group was higher than that in the control group and diamineoxidase was lower than that in the control group (P<0.05).Conclusion Double somatostatin combined with early enteral nutrition support can improve inflammatory factors and intestinal permeability in patients with severe acute pancreatitis, and is worthy of popularization and application.

Objective To investigate the effect of irinotecan hydrochloride combined with cisplatin on B-cell lymphoma-2 (Bcl-2) and metastasis-associated in colon cancer-1 (MACC1) protein expressions in cervical epithelial tissue of cervical cancer patients.Methods 100 patients with cervical cancer from January 2010 to January 2013 in Department of Obstetrics and Gynecology of Shangrao City People's Hospital were selected as objects.All patients were treated with irinotecan hydrochloride and cisplatin for combination chemotherapy.The clinical effect and the protein expressions of Bcl-2 and MACC1 of cervical epithelial tissue were compared pre-and post-chemotherapy.Results The total efficiency was 75.0%(75/100) after cervical cancer patients were given irinotecan hydrochloride combined with cisplatin chemotherapy program.The expressions and high expression rates of Bcl-2 and MACC1 post-chemotherapy were significantly lower than that pre-chemotherapy(P<0.05) .In clinically effective group, the high expression rates of Bcl-2 and MACC1 post-chemotherapy significantly reduced than pre-treatment (P<0.05), and in clinical invalid group, the difference of the high expression rates of Bcl-2 and MACC1 had no statistically significant.Conclusion After combination chemotherapy with irinotecan hydrochloride and cisplatin on cervical cancer, the expression of Bcl-2 and MACC1 in cervical epithelial tissue significantly reduce, and the clinical efficacy is aignificant.

Objective To investigate the clinical effect of surgical treatment of acetabular fractures. Methods From June 1995 to December 2000, 62 cases of acetabular fracture with dislocation were treated with open reduction and internal fixation. There were 13 cases with fractures of the posterior wall, two with posterior column fractures, three with anterior column fractures, five with transverse fractures, 15 with transverse and posterior wall fractures, three with posterior column and wall fractures, five with T-shaped fractures, four with anterior and hemi-transverse fractures and 12 with fractures of both column. Kocher-Langenbeck (K-L) approach was applied in 37 cases, ilioinguinal approach in 12, extended iliofemoral approach in four, iliofemoral approach in two, and combined approaches (K-L+ilio-inguinal) in seven. Results Anatomic reduction was done in 37 cases, with satisfactory results in 17 and unsatisfactory results in eight. Reduction for joint vallatae was performed in four cases. The follow-up was 1-5 years (average 2.7 years). The total excellence rate of clinical results was 71% (44/62), with excellence rate in anatomic and non-anatomic reduction groups for 89% (33/37) and 44% (11/25), respectively, with a very significant difference (?2=22.89, P

OBJECTIVE: To discuss the clinical efficacy of adenoidectomy and tonsillectomy for the OSAHS children with sinusitis. METHOD: Reviewing 112 cases of children with OSAHS, in which the 80 patients without chronic sinusitis, 32 ones with chronic sinusitis. Among them, 103 cases of children with adenoidectomy, tonsil resection, 9 cases adenoidectomy only. We did questionnaire survey before and after surgeryand also did post-surgery clinical follow-up. RESULT: The effective rate was 90.0% for the OSAHS children without sinusitis after adenoid and tonsil ectomy surgery, while the effective rate was 46.9% for the ones with sinusitis, the efficiency was significant different in the two groups after surgery; the 16.1% children after tonsil ectomy surgery complained the incidence of pharyngeal foreign body sensation and pharyngeal lymphoid hyperplasia in children was 23.2%. CONCLUSION The efficiency was aviable for the OSAHS children without sinusitis after surgery; The efficiency was not aviable enough for the OSAHS children with sinusitis after surgery, so the latter one need adjuvant drug treatment; We also should be attention to the pharyngeal foreign body sensation and the lymphoid hyperplasia in children after tonsillectomy.
Adenoidectomy ; Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; Retrospective Studies ; Sinusitis ; complications ; therapy ; Sleep Apnea, Obstructive ; complications ; surgery ; Tonsillectomy ; Treatment Outcome

Objective To investigate the protective effects of FUZHENGJIEDU,a kind of Chinese herb on rats exposed to radon and it's daughter.Methods Twelve male SD rats were exposed with concentration of 40 000 Bq/m3 radon and the exposed dose was 120 work level month (120 WLM),and then all the rats were randomly divided into 2 groups.One group was 120 WLM group (positive control,n=6 ),the other group was FUZHENGJIEDU treatment group (120 WLM exposed rats were given FUZHENGJIEDU 5.0 g every day,n =6),meanwhile 6 rats which lived in the normal environment ( the concentration of radon and it's daughter was lower than 50 Bq/m3 ) as control group.The levels of tumor markers induding carcinoembryonic antigen ( CEA),neuron-specific enolase (NSE),CYFRA21-1 and p53 antibody were tested by ELISA.The rate of p16 gene methylation was measured by methylation-specific PCR (MSP).Results The levels of CEA and NSE in 120 WLM group were (396.62 ± 148.74) and (9.09 ±0.90) μg/L,respectively,significantly higher than those of control group (t =2.583,2.463,P ＜ 0.05).The levels of CEA and NSE in treatment group were (70.89 ±44.71) and (4.31 ±1.37) μg/L,respectively,remarkably lower than those of 120 WLM group (t =2.921,2.526,P ＜0.05 ).The concentrations of CYFRA21-1 and p53 antibody were not significantly different among the three groups (t =1.713,1.963,P ＞ 0.05 ).The rate of p16 gene methylation in BALF cells in 120 WLM group was 16.67％,but in control group and treatment group did not arise p16 gene methylation in BALF cells.Conclusions FUZHENGJIDU would decrease the levels of CEA and NSE and the rate of p16 gene methylation,and could exert it's protective effect on rats exposed to high concentration of radon.

Objective To assess the influence of overall nursing intervention and lumbar and abdominal muscle strength training on the lumbar vertebral function of patients with lumbar intervertebral disc protrusion. Methods Seventy-six patients with lumbar intervertebral disc protrusion treated in our hospital from May 2013 to December 2014 were ran-domly divided into the control group and the observation group. The control group was given simple lumbar and ab-dominal muscle strength training, and the observation group was given additional overall nursing intervention on the ba-sis of lumbar and abdominal muscle strength training. The changes of lumbar vertebral function scores and the patient satisfaction rates of the two groups were compared. Results Before nursing training, the two groups were not signifi-cantly different in the lumbar vertebral function score (P>0.05); after nursing training, the observation group was sig-nificantly higher than the control group in the lumbar vertebral function score, with statistically significant difference(P<0.05). The observation group was significantly higher than the control group in the patient satisfaction rate, with statistically significant difference between the two groups (P<0.05). Conclusion Overall nursing intervention and lum-bar and abdominal muscle strength training can effectively improve the patients' awareness of disease,gain their treat-ment compliance and show remarkable effects and high patient satisfaction rate,thereby worthy of clinical promotion.

Objective To compare the in-hospital and follow-up clinical results of percutaneous coronary intervention(PCI)and coronary artery bypass grafting(CABG)in patients of left ventricular dysfunction with coronary artery disease.Methods 147 patients with left ventricular dysfunction were divided into PCI group(n=60)and CABG group(n=87).Clinical,angiographic and revascularization data were collected for analysis.Patients were by SPSS 13.0 software.P value of less than 0.05 was considered statistically significant.Results In-hospital MACCE rates and mortality ofthe two groups were comparable[(6.7%vs 9.2%,P＞0.05)and(1.7%vs 8.0%,P＞0.05)].Multivariate Logistic regression analysis indicated that in-hospital MACCE risk of the two groups were similar(OR≥3.03,95%CI 0.27～34.48,P＞0.05).22-month follow-up showed no signficance in MACCE rates (16.0%vs 13.8%,P＞0.05)and in repeated revaseularization rates(8.O%vs 1.7%,P＞0.05)between the two groups.Multivariate Cox regression analysis indicated that follow-up MACCE risk of the two groups were comparable (HR≥1.35,95%C/0.44～4.13,P＞0.05).Conclusion In coronary artery disease patients with left ventricular dysfunction,PCI and CABG have similar in-hospital and long-tem MACCE rates.Long-terra effect of PCI would be further increased with the wide use of drug-eluting stents.

OBJECTIVETo investigate the prenatal ultrasonic manifestations of fetal gray matter heterotopias (FGMH) and evaluate the optimal method its prenatal diagnosis.

METHODSThe prenatal and postnatal ultrasound images and MRI images were analyzed for a fetus with a definitive diagnosis of FGMH. The detection rates of FGMH by prenatal ultrasound and MRI reported in literature were compared.

RESULTSWe identified 11 reports of FGMH from 1998 to 2015, involving 43 cases with prenatal diagnoses. Of the total of 44 cases (including our case), 32 that had been confirmed postpartum had prenatal ultrasound and MRI data, which showed a significantly lower detection rates of FGMH by prenatal ultrasound than by MRI (43.8% vs 93.8%, P<0.001).

CONCLUSIONPrenatal ultrasound can only detect subependymal heterotopia with characteristic manifestations, and the detection of other types of FGMH relies on MRI, which is currently the best option for prenatal diagnosis of FGMH.

Classical Lissencephalies and Subcortical Band Heterotopias ; diagnosis ; Female ; Fetal Diseases ; diagnosis ; Fetus ; Gray Matter ; pathology ; Humans ; Magnetic Resonance Imaging ; Pregnancy ; Prenatal Diagnosis ; Ultrasonography, Prenatal

Objective:To investigate the diagnostic value of peripheral blood systemic immune inflammatory in-dex(SII)in histological chorioamnionitis(HCA)and the predictive value of adverse pregnancy outcomes.Meth-ods:A total of 138 pregnant women with suspected HCA were included from January 2021 to June 2022 in Peo-ple's Hospital of Zhengzhou as the research objects.According to the results of placental pathology examination,they were divided into non-HCA group(66 cases)and HCA group(72 cases).The general clinical data,laboratory indicators and adverse outcome indicators of the two groups were compared,and the relationship between the a-bove indicators and HCA was analyzed by multivariate Logistic regression.ROC curve was used to analyze the predictive value of SII for HCA and adverse pregnancy outcomes.Results:①Logistic regression analysis showed that increased neutrophil percentage(Neut％)and SII could increase the risk of HCA(OR＞1,P＜0.05),and in-creased lymphocyte percentage(Lym％)was beneficial for reducing the risk of HCA(OR＜1,P＜0.05).②ROC curve analysis showed that the area under the curve(AUC)of Neut％and Lym％for diagnosing HCA were 0.628 and 0.638,respectively,while the AUC of SII was higher(0.722),and the diagnostic threshold of SII was 974.49 ×109/L.③The rates of postpartum hemorrhage,neonatal infection and premature delivery in high SII group(SII＞974.49 ×103/L)were higher than those in low SII group(SII ≤974.49 ×109/L),and the difference was statistically significant(P＜0.05).The value of SII in predicting postpartum hemorrhage(AUC 0.708)and neonatal infection(AUC 0.848)were higher than that in preterm birth(AUC 0.637).Conclusions:Abnormal Neut％and Lym％levels increase the risk of HCA to some extent,but the diagnostic value of HCA is average.Peripheral blood SII has high diagnostic value in HCA,and has good predictive value for postpartum hemorrhage and neonatal infection,which is expected to be a new indicator for prenatal diagnosis and prognosis prediction of adverse pregnancy outcomes in HCA.