This is a review of recent progress in the study on environment sensitive hydrogel based on cyclodextrin and their most recent and relevant applications in the intelligent drug delivery systems. Based on relevant literatures, the development of environment sensitive hydrogel responsive to physical, chemical and biochemical stimuli was introduced, involving their categorization, design principles, mechanism of action and potential application. Various new types of intelligent drug delivery system, which responds to various triggers, could be constructed by using the cyclodextrin-based environment sensitive hydrogel. They made it possible to control the drug release freely. Although these hydrogels are still at their research stage, they have attracted considerable interest in the intelligent drug delivery system.

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is characterized by non-cardiogenic,acute,progressive and hypoxic respiratory insufficiency or respiratory failure mediated by various internal and external stimuli.The pathogeny of lung injury is varied,pathogenesis is complicated,and it is not clear.Related pathogeny and pathogensis of lung injury is reviewed as follows.

Adenoviridae ; genetics ; Genes, p53 ; Genetic Therapy ; methods ; Genetic Vectors ; Humans ; Neoplasms ; therapy ; RNA Interference ; Tumor Suppressor Protein p53 ; genetics

Anticancer drugs resistance is often ascribed to gene mutation,amplification or epigenetic changes that affect the uptake,metabolism or export of drugs at the cell level.Tumor physical microenvironment not only influences the drug distribution but also causes difference in cell proliferation rate and hypoxia or acidosis due to its heterogeneity,which could affect the tumor drug resistance.This review discusses the relationship between cancer physical microenvironment and drug resistance and the strategies for enhancement of the chemotherapy sensitivity through modification of the tumor physical microenvironments,as well as foreground of the research.

OBJECTIVE:To observe the safety and immunological effects of Measles-mumps-rubella(MMR)attenuated live at-tenuated vaccine in children. METHODS:300 children aged 8-12 months receiving inoculation were selected from Changsha Hospi-tal for Maternal and Child Health Care during Jan. 2015-Apr. 2016 to observe safety and immunological effects. Those children were divided into MMR group,measles vaccine group,mumps vaccine group and rubella vaccine group according to vaccine type, with 75 cases in each group. The occurrence of ADR in 72 h were compared among 4 groups after inoculation;venous blood of chil-dren was collected before vaccination and 5 months after vaccination,and the antibody positive test was carried out by micro coagu-lation inhibition (HI) test;HI antibody titer was recorded after immunization,and positive rate and genometric meantiter(GMT) were calculated. RESULTS:The incidence of ADR in 4 groups were 9.33%,8.00%,8.00% and 10.67%,respectively. No local ADR was found in 4 groups;among systemic ADR,the incidence of fever was higher than that of other clinical manifestations,be-ing 4.00%,4.00%,4.00% and 5.33%;there was no statistical significance in the incidence of ADR among 4 groups(P>0.05). Measles,mumps and rubella antibody positive rates of MMR group were 100%,92.00% and 100%,respectively;antibody posi-tive rates of measles vaccine group,mumps vaccine group and rubella vaccine group were 100%,85.33% and 100%,respective-ly;there was no statistical significance in same antibody positive rate among 4 groups(P>0.05). GMT of measles in MMR group and measles vaccine group were 1∶41 and 1∶27,that of mumps in MMR group and mumps vaccine group were 1∶6.3 and 1∶6.2, there was no statistical significance (P>0.05);GMT of rubella in MMR group and rubella vaccine group were 1∶320 and 1∶849, with statistical significance (P<0.05). CONCLUSIONS:Compared to traditional single vaccine,MMR dose not increase the inci-dence of ADR and not influence positive rate,but GMT of rubella increases significantly,to which should be paid attention.

AIM: To explore the effects of carbonizing temperature and time on HPLC fingerprints of Flos Sophorae for improving the processing technics of Flos Sophorae carbonized.METHODS: Samples were prepared by an oven for different time and at different temperatures,separately.Then the fingerprints of the samples were determined by HPLC,separately.According to the fingerprints of the crude drug,the differences between the fingerprints of the samples were compared. RESULTS: Heated for 30 min,there was no significant change of the fingerprints of the samples which were heated at 120(?C)-150(?C);there was a little change in the fingerprints when the samples were heated at 170(?C),but the significant change was observed when they were heated at 180(?C)-190(?C).The fingerprints showed the chemical constitutents were almost destroyed over 200(?C).Over 160(?C),the effects on the samples which were heated for 60 min were more obviously than on those which were heated for 30 min. CONCLUSION: According to the change of the fingerprints and in view of the efficient usage of the energy,Flos Sophorae carbonizing should be heated at 185(?C)?2 (?C) and for 30 min.

Objective To build an index system for ergonomic evaluation of cockpit display.Method The modified Delphi method was proposed to build the index system.Firstly,on the basis of systematic,in-depth analysis and integration of the related information such as military standards,norms and technical productions both domestic and abroad,an index system for cockpit display ergonomic evaluation was primarily built.Then,23 fighter pilots were referred twice as the specialized consultants upon preliminary index system with the modified Delphi method.Finally,the comements of the specialized consultants were statistically analyzed.Result Based on the two times of information from the specialized consultants,the indexes that could cause more impact on pilots' efficiency were selected.Conclusion Modified Delphi method characterized with referring and synthesizing experimental results from experts is scientific and operatable.

Objective To retrospectively analyze of blood culture positive for adult patients with serum calcium concentration ,to understand the relationship between bloodstream infections in patients and serum calcium .Methods From January 2013 to July 2015 ,serum calcium (Ca) ,phosphorus (P) ,alkaline phosphatase (ALP) in 78 cases with the blood culture positive adult patients and 103 healthy subjects were detected and analyzed .Results The value of CA in adult patients was(1 .89 ± 0 .18) mmol/L ,healthy subjects while of that was (2 .23 ± 0 .23)mmol/L in healthy subjects ,There was statistically significant (P<0 .01) in two groups ;The P of patients was (1 .23 ± 0 .24)mmol/L ,which in healthy subjects was (1 .25 ± 0 .28)mmol/L ,There was no statistical differ‐ence (P>0 .05);ALP of patients was (78 ± 42)U/L ,which was (76 ± 40)U/L in healthy subjects .There was no statistical differ‐ence (P>0 .05) ,the r of Ca and P ,Ca and ALP were 0 .023 ,0 .023 respectively (P>0 .05) in patients ,while there were 0 .125 and 0 .132 (P<0 .05) in healthy subjects .Conclusion Calcium in serum of adult patients with blood culture positive might be reduced .

Objective To explore after brainstem stroke patients with dysphagia by modified balloon dilation of the clinical effect of treatment and before and after the treatment in patients with pharyngeal function change by swallowing angiog -raphy digital analysis method for analysis and evaluation .Methods 60 patients with dysphagia after collection of brainstem stroke in our hospital were randomly divided into two groups .Control group (30 cases) underwent routine dysphagia rehabili-tation training in the treatment , and the observation group of 30 cases in the control group on the basis of the treatment added with balloon dilatation for treatment .Comparative analysis of pharyngeal contraction rate ( PCR) and pharyngeal contraction time between two groups before and after treatment were assessed by swallowing and digital measurement .Results There was no significant differences in PCR between two groups of patients before treatment ( P>0.05 ) .Compared with before treat-ment, the two groups of patients after treatment with different food PCR were significantly improved , and the difference was statistically significant (P<0.05).The improvement degree of the observation group was more significant than the control group (P<0.05).There was no significant difference between the two groups of patients before treatment (P>0.05).Com-pared with before treatment and after treatment in two groups of patients with different swallowing food pharyngeal contraction duration were significantly improved , and the difference is statistically significant ( P<0.05 ) and to improve the degree of the observation group compared with the control group is more significant ( P<0.05 ) .Conclusion The digital analysis technology of swallowing angiography can effectively evaluate the changes of pharyngeal function in patients with dysphagia af -ter stroke.It is worth to be further popularized .

Objective To synthesize of water-solubility derivant of 6,7,4′- trihydroxyisoflavone(T2 ),to characterize its structure and to evaluate its anti-tumor activity.Methods The sulfonic group(-SO3 H)was grafted to 3'position in loop B of T2 through sulfonation reaction,then strong aqua was added to above production,and obtained a water-solubility elevated compound named T2-SO3 (NH4 )2 through ammoniation.The construction of T2-SO3 (NH4 )2 was characterized by 1 H-NMR,13 C NMR,MS and element analysis.Its activity for killing human breast cancer cells (Hela)was analyzed by CCK-8 assay and flow cytometry.Re-sults The two kinds of water-solubility derivant of T2-SO3 H·2H2 O and T2-SO3 (NH4 )2 were obtained through above methods, and their yield rates were 96% and 75% respectively.The biological experiments showed that the anti-tumor activity of T2-SO3 (NH4 )2 was significantly enhanced.Conclusion Compared to T2,T2-SO3 (NH4 )2 exhibit higher biocompatibility and anti-tumor activity with vast biological application prospect.