Objective To explore the curative effect of budesonide combined with terbutaline via atomiza-tion-inhalation in treatment of the acute episode of infantile asthma and its impaction on pulmonary function. Methods 80 children with acute episode of bronchial asthma were randomly divided into observation group and control group. Both groups received comprehensive therapy, moreover, the observation group was treated with aerosol inhalation of budesonide and terbutaline additionally. Results The excellence rate (65% ) and the total effective rate (98% ) of the observation group was significantly higher than those of control group(30% ,75% ) (P <0.05). In control group, there were no significant differences in FEV, and FEV,% between the pre-treatment and post-treatment (P>0.05). In observation group,FEV1 and FEV1% post-treatment were higher than those in pre-treatment(P<0.05). The improvements of FEV, and FEV, % in observation group were significantly higher than those in control group ( P < 0.05 ). Conclusion The treatment of budesonide combined with terbutaline via atomization-inhalation for the acute episode of infantile asthma could improve the clinical efficacy and pulmonary status, which was a safe, quick and effective method for children' s bronchial asthma.

Objective To compare the effects of two different chemotherapies in treatment acute myeloid leukemia(ALM) patients.Methods sVEGF concentration was measured by ELISA in 32 AML patients.Section one,15 patients,combined with Ara-C,daunorubicin,etoposide and intrathecal Ara-C.Section two,17 patients,consisted of a combination of Ara-C,idarubicin,etoposide,mitoxantrone and intrathecal Ara-C.Results sVEGF level was significantly increased in newly diagnosed AML.The level of sVEGF in AML after 2 cycles of standard chemotherapy was significantly lower than newly diagnosed cases,but the effect of section two was much better compared with section one.Compared with the section one,the complete remission rate of section 2 was 82.4％ (P ＜ 0.05 ).Conclusion sVEGF as a proangiogenesis factor was significantly increased in serum with AML.The level of sVEGF in patients with AML obtained thermotherapy was significantly lower than that of pre-treating AML ones.VEGF should play a very important role in the leukemogenic process.The section two therapy should be used clinically.

Objective To observe the effect of pulmonary surfactant-associated proteins ( Kelisu) combined with ambroxol in the treatment of 180 congenital alveolar dysplasia children with neonatal respiratory distress syndrome ( NRDS) .Methods According to random number table ,180 congenital alveolar dysplasia children with NRDS were randomly divided into the observation group and control group , 90 cases in each group .In addition to conventional therapy,the control group was given ambroxol hydrochloride treatment ,the observation group was given Kelisu on thebasis of treatment of the control group.The treatment effect was compared between the two groups .Results Comparedwith the control group,after treatment the values of PaO2 and pH were significantly increased,PaCO2 significantly decreasedin the observation group(t =5.91,13.16,29.89,2.98,5.11,8.13,all P <0.05).The duration of mechanicalventilation,length of hospital stay were (45.30 ±5.35)h,(10.01 ±2.24)d in the observation group,respectively,which were significantly better than[(68.27 ±6.13)h,(17.24 ±2.39)d]in the control group(t =26.78,20.94,all P <0.05).Conclusion Kelisu combined with hydrochloride ambroxol can significantly improve hypoxia symp -toms in NRDS children,reduce the duration of mechanical ventilation and length of hospital stay ,improve the prognosis.

Objective To investigate speed-thorn Ghost-point combined with three-edged needle puncture bleeding and cupping in treatment of breast hyperplasia in order to expand the scope of the treatment of Ghost-point.Methods 35 patients with breast hyperplasia were treated three courses with speed-thorn Ghost-point combined with three-edged needle puncture bleeding and cupping.The changes of breast pain and tumor size were observed before and after the treatment.Results 35 patients with breast hyperplasia were significantly improved in their symptoms of breast pain by Ridit analysis(P<0.01),and compared with those before treatment after treatment there was signifi-cant difference,and a total effective rate was 86%.Conclusion The speed-thorn Ghost-point combined with three-edged needle puncture bleeding and treatment of cupping could effectively reduce breast pain and tunlor size in pa-tients with breast hyperplasia,and the method was simple and curative effect.

BACKGROUND: Cancer stem cell is a minority population of cancer cells in multiple myeloma possessing the properties of stem cells: self-renewal, multi-directional differentiation and long-term proliferation, which mediating disease initiation, relapse, progression and drug resistance. OBJECTIVE: To review characteristics of biology, phenotypic analyses, sorting and identification in clonogenic myeloma cells, the signaling pathways with in myeloma stem cells and the target therapy related. METHODS: Application of computer search Medline database (1999-01/2009-04), using "multiple myeloma stem cells, heterogeneity, phenotypic analysis, signaling pathways, target therapy" as key words ;application of computer search CNKI database (1999-01/2009-04) and CBM Database (1999-01/2009-04) using "multiple myeloma stem cells, heterogeneity, stem cell separation and identification, signal transduction, targeted therapy as key words" . RESULTS AND CONCLUSION: We collected for 126 literatures on the multiple myeloma stem cell-related, which include 30 Chinese articles and 96 English articles, excluding published earlier, repeated, and similar studies into 30 sub-standard literatures. Now widely recognized that multiple myeloma stem cells may be derived from normal stem cells, the accumulation of mutations and by gene mutation in regaining self-renewal capacity of progenitor cells or fully differentiated mature cells. Circulating clonotypic memory B-cell populations have self-renewal and multi-directional differentiation potential, which represent the cancer stem cells in multiple myeloma. The exact phenotype of multiple myeloma cancer stem cells has not been definitively established and researched remains. At present, both the side population cells and aldehyde dehydrogenase (ALDH) activity assays were mainly capable of isolating multiple myeloma cancer stem cells. Which to possess self-renewal ability by Hedgehog ,Wnt and Notch signaling pathways. When these signal transduction pathways appear abnormal, leading to the occurrence of the tumor and tumor cell growth in non-controlled. Against the cancer stem cell targeted therapy is a new and important direction of selective therapeutic strategies. Cancer stem cell specific surface markers and signal transduction pathways can be used as anti-cancer stem cells to control tumor development targets.

BACKGROUND: Cancer stem cell is a minority population of cancer cells in multiple myeloma possessing the properties of stem cells: self-renewal, multi-directional differentiation and long-term proliferation, which mediating disease initiation, relapse, progression and drug resistance.OBJECTIVE: To review characteristics of biology, phenotypic analyses, sorting and identification in clonogenic myeloma cells, the signaling pathways with in myeloma stem cells and the target therapy related.METHODS: Application of computer search Medline database (1999-01/2009-04), using "multiple myeloma stem cells, heterogeneity, phenotypic analysis, signaling pathways, target therapy" as key words; application of computer search CNKI database (1999-01/2009-04) and CBM Database (1999-01/2009-04) using "multiple myeloma stem cells, heterogeneity, stem cell separation and identification, signal transduction, targeted therapy as key words".RESULTS AND CONCLUSION: We collected for 126 literatures on the multiple myeloma stem cell-related, which include 30 Chinese articles and 96 English articles, excluding published earlier, repeated, and similar studies into 30 sub-standard literatures. Now widely recognized that multiple myeloma stem cells may be derived from normal stem cells, the accumulation of mutations and by gene mutation in regaining self-renewal capacity of progenitor cells or fully differentiated mature cells. Circulating clonotypic memory B-cell populations have self-renewal and multi-directional differentiation potential, which represent the cancer stem cells in multiple myeloma. The exact phenotype of multiple myeloma cancer stem cells has not been definitively established and researched remains. At present, both the side population cells and aldehyde dehydrogenase (ALDH) activity assays were mainly capable of isolating multiple myeloma cancer stem cells. Which to possess self-renewal ability by Hedgehog ,Wnt and Notch signaling pathways. When these signal transduction pathways appear abnormal, leading to the occurrence of the tumor and tumor cell growth in non-controlled. Against the cancer stem cell targeted therapy is a new and important direction of selective therapeutic strategies. Cancer stem cell specific surface markers and signal transduction pathways can be used as anti-cancer stem cells to control tumor development targets.

Objective To observe the clinical effect of Shexiang Baoxin pill,a traditional Chinese medicine,combined with nicorandil on microvascular angina pectoris.Methods Seventy patients with microangiopathic angina diagnosed by coronary angiography admitted to the First Affiliated Hospital of Baotou Medical College from January 2014 to August 2016 were enrolled,and they were divided into a control group and an observation group according to conplete random number table method,35 patients in each group.Both groups were given routine treatment,in the observation group,additionally,nicorandil 5 mg 3 times a day and 2 Shexiang Baoxin pills (22.5 mg per tablet),3 times a day were orally applied,the therapeutic course in both groups being 6 weeks.Before and after treatment,the changes of number of episodes of angina pectoris per week,of the total number of ST-segment depression leads and the minimum voltage amplitude of ST-segment depression in the 12-lead resting electrocardiogram and adverse reaction were observed in the two groups.Results The frequency of angina pectoris after treatment was less than that before treatment,the total number of ST segment depression leads was lower and the minimum voltage amplitude of ST segment depression was decreased compared with those before treatment in the two groups,the degree of change in the observation group being more significant than those in the control goup [angina attack frequency (times):5.2 ± 0.5 vs.9.4 ± 1.6,ST segment depression lead total number:2.3-± 0.2 vs.4.6 ± 2.1,ST segment depression lowest voltage amplitude (my):0.10 ± 0.01 vs.0.31 ± 0.01,all P ＜ 0.05].The adverse effects incidence showed no statistical significant differences between control group and observation group [14.3％ (5/35) vs.22.8％ (8/35),P ＞ 0.05] Conclusions On the basis of conventional medication,Shexiang Baoxin pills combined with nicorandil has obvious therapeutic effect for treatment of microangiopathic angina pectoris.

Objective To explore the influence of nursing intervention on patients with schizophrenia receiving repetitive transcranial magnetic stimulation (rTMS) treatment.Methods A total of 80 patients with schizophrenia receiving (rTMS) treatment were randomly divided into intervention group 40 cases and control group 40 cases by random digits table method.The control group was given routine care, and the intervention group was given routine nursing and nursing intervention.Before and after treatment, the curative effect was evaluated by the Positive And Negative Symptoms Scale, and the completion of the treatment between two groups was compared.Results The Positive Scale score, Negative Scale score, General Psychopathology Scale, total score in intervention group after treatment were lower than those in control group:(13.1±2.3) points vs.(16.7±2.1) points,(11.5±2.6) points vs.(15.3±2.3) points, (28.3±2.3) points vs.(30.9±2.2) points,(56.9±1.8) points vs.(67.4±1.7) points, and there were significant differences, t=2.398,2.401,2.452,2.191 ,P＜0.05.There was no significant difference in the rTMS completion, x2=5.541, P＜0.05.Conclusions Nursing intervention can effectively improve the patients with schizophrenia completion of rTMS treatment to improve mental symptoms, so as to improve the clinical curative effect, promote patients recovery of disease.

Background and purpose:Nausea and vomiting were the most common side effects of chemotherapy and they are difficult to control especially in terms of delayed nausea and vomiting induced by CDDP. Acupuncture treatment is popularly the traditional medical method used in China,being economic and easy to carry out.This research is to study the role of acupuncture treatment in the prevention of NP regimen induced delayed nausea and vomiting. Methods:26 patients with NSCLC were enrolled into a randomized double blind crossover trial. The patients received either hydrochloride ondostrone+Dexm+acupuncture treatment(the first cycle of chemotherapy) →hydrochloride ondostrone+Dexm (the second cycle of chemotherapy)(defined as AB group) or hydrochloride ondostrone+Dexm (the first cycle of chemotherapy)→hydrochloride ondostrone+Dexm+acupuncture treatment (the second cycle of chemotherapy)( defined as BA group).Results:Twenty six patients were evaluated. The complete controls of nausea for the AB group with acupuncture treatment were 96.15%, 96.15%, 76.92%, 84.62%, 92.31% and 100.00% for day 1-6, respectively, for the BA group without acupuncture treatment were 100.00%, 76.92%, 57.69%, 34.62%, 65.38% and 76.92%, respectively. There were statistically difference in terms of the control of nausea for day 3-5(P

AIM To investigate the protective effects of dauricine on anoxia and acute cerebral ischemia-reperfusion in mice. METHODS In this study, anoxia was induced by close normobaric hypoxia to search the effects of dauricine on the survival time of mice. The activities of SOD, GSH-Px and levels of MDA in cortex or mitochondria, the activities of cortex LDH and mitochondria ATPase were all measured by ELISA-Reader and spectrophotography. RESULTS ① Dauricine prolonged the survival time of mice in the close normobaric hypoxia, among all doses, Dauricine 60 mg?kg -1 and 120 mg?kg -1 had significant most effects (P