Carcinoma, Papillary ; surgery ; Carotid Arteries ; surgery ; Diffusion of Innovation ; Humans ; Knowledge ; Laryngeal Neoplasms ; surgery ; Laryngectomy ; methods ; Reconstructive Surgical Procedures ; methods ; Surgical Flaps ; Thyroid Neoplasms ; surgery ; Thyroidectomy ; methods ; Voice Disorders ; etiology ; surgery

Subclavian artery occlusion is a common peripheral artery occlusion disease of various causes,with incidence of 1.9％.The most common symptoms are dizziness,ataxia,and hemiplegia that are caused by subclavian steal syndrome.Surgery is the only therapeutic method for symptomatic patients.Open surgery remains an important role despite of the rapid progress in endovascular surgery.Main surgical method includes carotid-subclavian transposition (CST),carotid-subclavian bypass (CSB) and axillary-axillary bypass.Each one is suitable for different lesions and anatomies.Both the effectiveness and safety have been testified.

Objective To explore the key elements in prescription and summarize the law of prescription-herb treatment, to find core herbs/herb group which play a key role in pharmacological effects, then provide new methods and modern techniques for theory of prescription development and TCM clinical research. Methods The text data sources of stroke disease were retrieved from databases of traditonal Chinese prescription. After pre-processing and information extraction, a prescription-herb matrix was constructed, and then biclustering method was used to simultaneous clustering two dimensions of data. Results Totally 648 effective records were gained after preprocessing, and 6913 herbs were extracted, then a 100×648 prescription-herb matrix was generated. Finally 4-way clustering results were output, along with 8 high descriptive prescriptions, then characteristics of prescription laws of diagnosis and treatment according different syndrome and various types of herbs commonly used were summarized. Conclusion This method can be well applied for prescription-herb knowledge discovery in TCM prescription databases. The prescription-herb information can be effectively extracted, and laws of prescription-herb and syndrome-treament can be mined.

Pharmacokinetic-pharmacodynamic(PK/PD)modeling,as an available tool accounting for the interrelated dynamic connection between the dosage and efficiency of drugs,plays an important role in the field of studying the mechanism and optimizing the clinical administration of traditional Chinese medicine(TCM).Based on the general illustration on the foregoing application of PK/PD modeling,the present work investigates the involving challenges in the field,such as the selection of the target chemical composition and effect mark.In accordance with the unique properties of TCM,further,the related suggestions,mainly focusing on determining the substances based on the effect and establishing the multi-index appraise system,are put forward as reference for the following research work.

Barrett's esophagus is known the only precancerous lesions of esophageal adenocarcinoma.Besides conventional endoscopy and pathologic biopsy,drugs and surgical treatment of the Barrett's esophagus,in recent years,some new endoscopic diagnosis and treatment technology were obtained.The progress of endoscopic diagnosis and therapy technique in Barrett's esophagus are reviewed in this paper.

Objective To explore the role of Joint Commission International(JCI) standards on the improvement of pharmaceutical care in pharmacy intravenous admixture service (PIVAS) during the JCI accreditation.Methods The changes of PIVAS in Huangshi Central Hospital were analyzed and compared during JCI accreditation in respect of facilities,software management,service processes,safety awareness of the PIVAS staff and pharmacy management,service evaluation,error rate,etc.Results After JCI accreditation,the process of PIVAS were optimized,the software were updated ,and the safety awareness of PIVAS staff was improved;the management of high alert drugs was implemented more strictly;more importance was attached to the details of pharmaceutical care;the satisfaction degree of the clinic units to PIVAS was increased from 87.0% in 2014 to 98.0% in 2015;error rate was decreased from 0.40‰ in 2014 to 0.15‰ in 2015.The incidence rate of defective product was decreased from 0.32‰ in 2014 to 0.07‰ in March 2015.The correct rate of medical waste classification treatment was increased from about 85.5% in 2014 to 100.0% in 2015.Hand hygiene compliance rate and correct rate were increased up to 100.0%.6S site management activity participation rate was increased up to 100.0%.Conclusion The application of JCI standards and the process of JCI accreditation improve the quality of pharmaceutical care in hospital PIVAS.It can improve the medical safety in hospital.

Reconstructing the three-dimensional finite element model of compression fracture of T_(12) based on the 210-layer consecutive CT DICOM format images from one patient of compression fracture of T_(12) to simulate the hyperextending. Bound the lower of T_(12), a vertical traction at the top of T_(11)and a 3.0 cm-displacement toward the vertebra by three steps at the top of spinous process of T_(11), T_(12) and L_1 was provided. The procedure began computing to reed the results about dynamic biomechanical characteristics of anterior longitudinal ligament. A realistic appearance and full biomechanical properties 3D finite element model of thoracolumbar spine compression fracture was established. The anterior longitudinal ligament was changed from relaxation to tension after hyperextending. The stresses of anterior longitudinal ligament were different when the hyperextending fulcrum was different. The treatment effect of thoracalumbar spine compression fracture by hyperextending is exact. The anterior longitudinal ligament plays an important role in the treatment. Finite element analysis of mechanism of traditional practices has many advantages, such as reliable experimental results, direct displaying results, saving resources and accurate simulation.

AIM: Studies reveal that, cytokines play an important role in the process of various inflammatory reaction, wound repair and cell mutation, also, cytokines are expected to be a novel indicator of ratiocinating wound time. This study was designed to explore the changes in gene expression of interlukin-1? (IL-1?) and interlukin-1? (IL-1?) during the skin wound healing process in mice at different phases. METHODS: The experiment was carried out in the laboratory of Forensic Medicine Department of China Criminal Police University from March 2006 to December 2007. ①Thirty-five BALB/c inbred male white mice of cleaning grade, aged 25-27 g, were used in this study. ②Skin wound model was induced by injuries in the area of 1.0 cm away from two sides of spinal column, without affection on muscles. Three pairs of injuries were established in each mouse. Five animals were decapitated under anesthesia at 0, 3, 6, 12 hours and 1, 3, 6 days, respectively, whereas those at 0 hour were taken as controls. ③The white blood cells at different phases were observed under microscope after immunochemical staining. Real-time quantitative polymerase chain reaction method was applied to detect gene expression of IL-1? and IL-1?. RESULTS: Thirty-five BALB-c inbred male white mice were all involved in the result analysis. ①Skin wound was weakly positive during 0-5 hours after injury; the positive reaction was attenuated during 6-24 hours, and positive cells increased, of which macrophages were dominant. Infiltration of massive leucocyte neutrophils and a small quantity of mononuclear cells were detectable at 1 day; mononuclear cells increased during 2-4 days, and reached a peak at 3 days. In control group, the epidermis, folliculus pili, glandulae sebaceae and coil gland were all weakly positive. ②IL-1? and IL-1? were expressed at early phase after injury, and two expressing peaks were found at 6 and 72 hours, then decreased to normalized levels at 6 days after injury. CONCLUSION: Genet expression of IL-1? and IL-1? in damaged tissues has a regularity with wound time, and can be used for reference to estimate early injury age in forensic cases.

Objective To study the roles of protein kinase C (PKC) in the signal transduction pathway of LPS induced nuclear transcription factor (NF) ?B activation of alveolar macrophages(AMs). Methods NF ?B level in nuclear protein extraction of AMs was detected by sandwich ELISA. Intranuclear translocation of NF ?B was observed by immunocytochemical staining. Results LPS could induce NF ?B activation of AMs in time and dose dependent manners. Immunohistochemical staining revealed intranuclear translocation following LPS induction. Specific calphostin C (Cal C) and pyrrolidine dithiocarbamate (PDTC) could inhibit LPS induced NF ?B activation. Conclusion PKC, as a up stream messenger, is involved in the signal transduction pathway of LPS induced NF ?B activation.

The county health service planning is a very important link in county health reform, the planning process involves many professional problems, such as the setting of total bed number and proportional allocation. To solve these problems, it is needed to find a feasible method. Methods:Using operational research theory and method of linear programming to estimate whether the resource amount could satisfy the needs, and further explore the problem of the health resources in county-township-village. Results:(1) Operational research method could be used to judge whether the total bed amount and rate in county and township are suitable;(2) but linear programming to allocate capital budget model still exist some defects. The blind expansion and the pursuit of institution beds scale expansion are the phenomenon at present stage, the linear programming method could effectively help to determine whether these resources is really insufficient or excess. The method could be expanded to urban areas so as to supervision whether health resources are over expanded.