Objective:Analysis of complex congenital heart disease of children and the incidence of coronary abnormalities to explore the21(4):453-457. diagnostic value of coronary angiography.Methods:Angiocardio graphy cardiac catheterization of 229 children in Heart Center of Children's Hospital Chongqing Medical University from January 2006 to June 2009,the results were retrospectively analyzed,including the types and proportion of congenital heart diseases,incidences of coronary artery abnormalities,incidences of abnormal coronary artery crossing right ventricular outflow tract and prognosis.Results:Altogether,27(11.8%)cases of children with Congenital Coronary Artery Anomalies were detected.Highest incidenc(e6.55%)is L-coronary artery,which occupy 55.56% of Coronary Artery Anomalies.16(6.99%) cases of abnormal coronary artery crossing the right ventricular outflow tract,which including 7 cases of TOF,3 cases of DORV,3 cases of PA/VSD,1 case of TGA,1 case of CAVC and 1 case of SV/TGA.1 patient died of angiocardiography among the 27 cases of complicating coronary artery malformation,accounting for 3.7%in the total number of the angiography of complex congenital heart disease complicating coronary artery malformation,accounting for 0.44%in the total number of complex congenital heart disease.3 cases died after surgery, accounting for 16.7% of surgery.Conclusion:The incidence of coronary artery abnormalities in complex congenital heart disease in children is higher than the normal population;coronary angiography is an important means of final diagnosis coronary artery congenital variation.

Objective:To analyze the clinical data of primary pulmonary hypertension in children and improve its clinical diagnosis and treatment.Methods:The clinical data of 6 patients with primary pulmonary hypertension were collected and analyzed.Clinical diagnosis was made by ways of electrocardiography,ultrasound,and X-ray.All of them were received catheterization examination and angiography.Results:Heart failures were found in all patients with PPH.Signs of pulmonary hypertension were found by accessory examination.No heart malformation was found by catheterization examination.Conclusion:There are all kinds of clinical manifestations of PPH.The definite diagnosis of PPH will rely on catheterization examination.

The chemical constituents of starfish Asterias amurensis have been extensively studied in China. Some unique and new chemical constituents have been isolated from Asterias amurensis ; they included saponins, sulfated sterols, amyloses, steroids, amino acids, etc. Many of them have anti-bacterial activities and hemolysis effects. We reviewed the related literatures published home and abroad, hoping to provide more evidence for further development of Asterias amurensis.

Aldehyde oxidase (AOX), a highly conserved molybdoflavoenzyme in mammal cytoplasm, has broad substrate specificity and ability to catalyze the oxidation of aldehydes and nitrogen, oxygen-containing heterocyclic rings. AOX was found to widely distribute with the individual differences in vivo and plays an important role in phase I metabolism of drugs and xenobiotics. The biological characteristics of AOX and its contributions in drug metabolism are introduced briefly in this review.

Micrometastasis are frequently accompanied by the majority of cases of invasive malignant tumor, being a compacted relationship with the prognosis of patients. We should pay more attentions to the occurrence of micrometastasis in the diagnosis and management of carcinoma of urinary bladder, which is the most commonly diagnosed malignancy in urinary system and a significant cause of morbidity and mortality.This article introduces the diachronic concept of micrometastasis and the major methods for the detections of micrometastasis, moreover,it reviews recent advances about the detection of micrometastasis in bladder cancer, and about the benefits that patients of the disease might have received in the treatment of micrometastasis.

Objective To analyze and compare the HBV DNA contents in serum and breast milk after injection of hepatitis B im‐munoglobulin (HBIG) in different periods of pregnant and lying‐in women to provide the experimental basis for blocking the mater‐nal‐neonatal transmission(PMTCT) and breast feeding scheme .Methods 140 pregnant women carrying hepatitis B virus with HB‐sAg(+ ) by antenatal examination in the obstetric outpatient department of our hospital from June 2012 to June 2014 were selected and divided into the research group and the control group according to the voluntary and secretive principle .Among them ,75 cases in the research group were intramuscularly injected by high titer HBIG 200 U at 28 ,32 ,36 weeks of pregnancy ,while 65 cases in the control group were injected by HBIG at the end of pregnancy due to different causes .Serum HBV‐DNA content before injection and before delivery was detected in the two groups ,and which in neonatal serum and breast milk within 3-5 d also detected .The differences and correlation between the two groups were analyzed .Results The HBV‐DNA content <500 copies/mL ,500-1 × 106 copies/mL ,>1 × 106 copies/mL before HBIG injection in the research group were 28 cases ,17 cases ,30 cases respectively ,which before delivery were 35 cases ,20 cases ,20 cases respectively ;which in antenatal twice detection in the control group were 19 cases , 21 cases ,25 cases and 20 cases ,17 cases ,28 cases respectively ;neonatal serum HBV‐DNA positive in the research group and control group had 1 case(5 .3% ) and 5 cases (7 .7% ) respectively ;the breast milk HBV‐DNA positive in the two groups had 3 cases(4% )/and 8 cases(12 .3% ) respectively .Conclusion HBIG injection at late pregnancy in the pregnant women carrying HBV could influ‐ence the HBV replication ,thus reduces the probability of neonatal intrauterine infection ,at the same time reduces the HBV‐DNA positive rate of postpartum breast milk .

Acupuncture Therapy ; Adult ; Diarrhea ; therapy ; Humans ; Male

China ; epidemiology ; Humans ; Metabolic Syndrome ; epidemiology ; prevention & control

Angiogenesis plays an important role in solid tumors and hematologic malignancies. Angiopoietins act as essential regulators in this process,complementary with another mediator-VEGF. In the development of hematologic malignancies, the expression of Angs/Tie-2 system is identified abnormal, especially for Ang-2, whose expression and prognostic impact have gained significant attention recently.

BACKGROUND:In the whole world, spinal cord injuries caused by trauma lead to more than 180 000 people presenting with permanent impairment annualy. A large number of experiments have confirmed in recent years, under physiological conditions, microRNA has specific expression and plays an important role in the nervous system. OBJECTIVE: To discuss the changes in microRNA expression induced by injuries as wel as the pathophysiological significance in spinal cord injury, and to explore the development potential of microRNA in tissue-engineered and clinical repair of spinal cord injury. METHODS:A computer-based search of PubMed and Chinese Journal Database was performed for related articles published from January 2000 to December 2014 using the keywords of “SCI, microRNA, transcriptional control, clinical research progress” in English and Chinese. Finaly, 38 articles were included for result analysis. RESULTS AND CONCLUSION: Mechanical injury initialy triggers a series of complex secondary damages, including nervous, vascular and immune systems, which can influence the severity of spinal cord injury to a great extent. Secondary damage to the spinal cord is mainly attributed to the activation and deactivation of some specific genes associated with celular and biochemical mechanisms, such as cysteine aspartate specific protease (caspase) gene family, apoptosis related protein Fas and its ligand Fasl system, P53 gene, apoptosis related gene Bcl-2 family. Recent studies have proved that the functional activation of microRNA expression is the key to spinal cord injury. With the development of biological information engineering, studies and controling technologies associated with microRNA expression have been gradualy dominated, some clinical application based on microRNA technology has entered the clinical trial stage. It is believed that with the continuous development of technology and decrease of cost, permanent dysfunction due to spinal cord injury can be regulated and repaired through the microRNA technology at gene level in the future.