0.05),but the total expenses and cost of the main medical treatment were(2765.85?484.99)and(737.50?100.30)yuan;(4506.70?671.31)and(2648.80?331.10)yuan,respectively,which demonstrated significant difference(P

Objective To establish an HPLC method for the simultaneous determination of CTX and DDP and to research their pharmacokinetics in rat. Methods The separation was performed on a Hypersil-CTX. Results Retention time of CTX was 5.15 min. The linearity range of calibration curve was 0.5-10 μg/ml (r =0.9999), the average recovery was 97.4 %(RSD＜5 %). The detection limit was 0.1 μg/ml(S/N＞3). For DDP the retention time was 9.26 min and the linearity range of calibration curve was 0.1-2.0 μg/ml (r =0.9998).The average recovery was 98.1%(RSD＜5 %). The detection limit was 0.1 μg/ml (S/N＞3). Conclusion The method is effective for determination of CTX and DDP. It also provides the method eligible for pharmacokinetics of CTX and DDP. Drug combination make eliminating rate decrease and eliminating half life prolong, have effect on each other.

OBJECTIVE:To study the cost-effectiveness of four kinds of calcium drugs in treating senile osteoporosis.METHODS:228cases of senile osteoporosis were collected and divided into four groups,which were Calcichew D 3 (A),Osteo?form(B),Calcium Citrate Tablets+Vitamin AD(C),Shengu Capsules+Vitamin AD(D).Data was evaluated using the phar?macoeconomic cost-effectiveness analysis.RESULTS:The costs of four groups were938.05、1346.85、1946.35and1690.85yuan respectively.The effective rates of four groups were95.6%、80.0%、68.0%and72.0%respectively.Compared with scheme A,scheme B、C、D drug price need to be decreased by41.5%、65.6%、58.1%respectively so that their cost-effec?tiveness ratios can be better than scheme A.CONCLUSION:Among the four schemes,A is the best one.

OBJECTIVE:To evaluate the cost-effectiveness of3Chinese and western medicines in treating senile func?tional constipation.METHODS:186patients with senile functional constipation were randomly assigned to receive Forlax powder preparation for infusion,Liuweianxiao capsule and Buzhongyiqitang respectively,the therapeutic efficacies of the3groups were observed and the cost-effectiveness analysis were conducted12weeks after treatment.RESULTS:The cure rates for the3groups were77.6%,83.3%and85.5%,respectively;the costs for the3groups were963.52yuan,877.00yuan and850.12yuan,respectively;the ratio of cost to effectiveness were1241,1052and975,respectively;the incremental cost-effectiveness ratio of Group A and B were1435and1221as compared with Group C.CONCLUSION:Liuweianxiao capsule(Group B)was the preferred option for the treatment of senile functional constipation.

China ; Education, Medical ; Occupational Health

The concept, connotation and extension of "similar-indication acupoints" which is proposed by Professor WANG Fuchun are introduced in this paper. It is noted that "similar-indication acupoints" is one category of acupoints that hass similar effects for one symptom or disease, which is the basic element for acupoints compatibility, while acupoint compatibility is the foundation of acupuncture acupoints prescription. The proposal and application of "similar-indication acupoints" has provided a new method for the transition from specificity study to generality study, also lay a solid theoretical foundation for acupoints compatibility search.
Acupuncture Points ; Acupuncture Therapy ; Humans ; Meridians

The vertebral artery dissection may be associated with the structural abnormalities of vascular wall or enviromental factors.The symptoms are usually caused by the luminal stenosis or the formation of blood clot,including the pain in posterior neck or mastoid region with local neurological deficits.The diagnostic methods for vertebral artery dissection include digital subtraction angiogaphy,magnetic resonance imaging,CT angiograpby and color Doppler ultrasonography.Anticoagulation is the main treatment option for most patients with vertebral artery dissection.

0.05), respectively; the costs of topiramate or sodium valproate retard tablets were 1 305.00 yuan and 588.60 yuan, respectively. CONCLUSION: Sodium valproate retard tablet is superior to topiramate tablet in terms of cost - effectiveness.

AIM: To explore whether NF-?B activation participates in the activated Akt signaling-induced cardiac hypertrophy in vivo. METHODS: We used two in vivo models of cardiac hypertrophy, namely, aortic banding in Sprague-Dawley rats for 3 weeks and transgenic mice with cardiac specific expression of constitutively active Akt (caAkt). Electrophoretic mobility shift assay (EMSA) was used to determine NF-?B binding activity with nuclear proteins extracted from heart tissues. Western blots were performed to examine the phosphorylation of Akt and phosphor-I?B? with appropriate specific anti-phospho antibodies. RESULTS: ① The heart weight/body weight (HW/BW) ratio was significantly increased by 34 5% ( P

β-Cyclodextrin-N-vinyl-2-pyrrolidone (CDM-NVP) copolymer was prepared by free radical chain reaction of N-vinyl-2-pyrrolidone (NVP) and β-CD maleate (CDM) with γ-ray as initiator.The synthesis conditions of CDM-NVP polymer were as follows: mass ratio of CDM to NVP was 1∶0.7 (CDM 3.6 g and NVP 2.52 g), irradiation dosage was 4 kGy, and DMF aqueous solution (50%, V/V) was set at 20 mL.Under the synthesis conditions, the yield of CDM-NVP was 84% and the weight-average molecular weight was 20 kD.The natamycin (NM) and carbendazim (MBC) could form stable inclusion complexes with CDM-NVP copolymer, and the solubility and fungicidal activity of the complexes were investigated.The stability constant of NM·CDM-NVP and MBC·CDM-NVP complexes at 303 K were 12, 988.54 L/mol and 865.94 L/mol, respectively.The complexes were characterized using phase solubility diagrams, nuclear magnetic resonance (NMR) spectra and ultraviolet (UV) spectra.The analysis of the biological activities of these two complexes indicated that they possessed enhancing fungicidal activities compared to NM and MBC alone.