Objective To analyze the clinical nusing care methods and effects of patients complicated with tuberculosis during pregnancy or puerperal state.Methods Clinical data of 39 cases of patients complicated with tuberculosis during pregnancy or puerperal state were retrospective analyzed.Results After comprehensive treatment and nursing care,4 cases died,others got good prognosis.Conclusions Meticulous treatment and nursing can promote the rehabilitation of patients complicated with tuberculosis during pregnancy or puerperal state.For these patients,the cure rate can be improved and the recurrence rate can be reduced by choosing suitable treatment and nursing care programs,paying attention to psychological care and health education,ensuring patients taking medicine regularly.

Breast Neoplasms ; blood supply ; classification ; genetics ; pathology ; Female ; Genes, BRCA1 ; Genes, MDR ; Genes, erbB-2 ; Humans ; Lymphatic Metastasis ; Mutation ; Neovascularization, Pathologic ; Sentinel Lymph Node Biopsy

Breast Neoplasms ; pathology ; surgery ; Carcinoma, Ductal, Breast ; pathology ; surgery ; Carcinoma, Papillary ; pathology ; surgery ; Combined Modality Therapy ; Disease-Free Survival ; Female ; Humans ; Mastectomy, Segmental ; Neoplasm Invasiveness

Breast Neoplasms ; diagnosis ; pathology ; Carcinoma ; diagnosis ; pathology ; Female ; Humans ; Male ; Mammography ; methods ; trends ; Neoplasm Invasiveness ; pathology ; Neoplasm Proteins ; analysis

Breast Neoplasms ; chemistry ; diagnosis ; pathology ; Carcinoma, Ductal, Breast ; chemistry ; diagnosis ; pathology ; Carcinoma, Papillary ; chemistry ; diagnosis ; pathology ; Diagnosis, Differential ; Female ; Humans ; Lymphatic Metastasis ; Neoplasm Invasiveness ; Prognosis ; Receptor, ErbB-2 ; analysis ; Receptors, Estrogen ; analysis

Angioimmunoblastic T-cell lymphoma(AITL) is a subtype of peripheral T-cell lymphoma,clinically characterized with systemic symptoms and aggressive behaviours. To date, the standard approach for treating patients with AITL is still unknown. Combination chemotherapy regimens have failed to significantly improve prognosis and durably maintain the remission. Targeted drugs and immunomodulator agents could not conclude the role because of the small number of patients in these studies. High dose therapy with autologous stem cell transplantation and allogeneic hematologic stem cell transplantation are both comparatively efficient.High dose therapy with autologous stem cell transplantation has many risks, such as higher relapse rate and long-term secondary tumor. Owing to higher transplant related mortality , allogeneic hematologic stem cell transplantation will be further explored. This review presents the status of treatment study in AITL.

Objective To explore the relationship between the protein expression of PCNA and biological behavior science in benignant pituita ry adenoma.Methods The protein expression of PCNA in 58 patien ts with pituitary adenoma were determined by ABC immunohistochemical method.Results The PCNA index was significantly higher in the patients with recurrent pituitary adenomas than in nonrecurrent ones(P<0.05).There was no significantly difference between bleeding and unbleeding group,cystic and noncystic group,large type and unlarge type group(P>0.05 respectively) .Conclusion The protein expressions of PCNA reflected the proli ferative activties of pituitary adenomas, and could be taken as one of the indic ators to evaluate recurrence and prognosis of the tumor.

Objective To evaluate the clinical value of Nevin and AJCC staging system for gallbladder carcinoma. Methods In this study 90 patients diagnosed as gallbladder carcinoma underwent operation in Renji Hospital from February 2000 to October 2006. Patients were staged according to Nevin and AJCC staging system. The difference of survival rate, tumor resection rate, ratio of tumor-free resection margin and surgical procedures were analyzed. Results The survival rate, tumor resection rate and ratio of tumor-free resection margin decreased progressively with increasing Nevin and AJCC stage (P < 0. 05). There was no significant difference between the survival rate for Nevin Ⅲ or Ⅳ patients undergoing radical resection and simple cholecystectomy (P > 0. 05). In Nevin Ⅴ patients, the survival rate for radical and extensive radical resection patients was higher than for palliative patients (P < 0. 05). In AJCC Ⅲ patients, the survival rate for radical patients was significant higher than for palliative patients (P < 0. 05). Nosignificant difference was found between radical and palliative patients in survival time in AJCC Ⅳ (P > 0. 05). 52 patients in AJCC Ⅲ and Ⅳ were staged to Nevin Ⅴ according to Nevin staging system. The survival rate and resectable rate for the patients in AJCC Ⅲ were higher than in AJCC Ⅳ (P = 0. 0001, 0. 001 respectively). The rate of radical operation in AJCC Ⅲ was higher (P = 0. 001), and the rate of palliative operation in AJCC Ⅳ was higher (P = 0. 001). Conclusion Both Nevin and AJCC staging system are useful in the judgement of survival, reeectability, ratio of tumor-free resection margin and the optimal operation. AJCC staging system is more applicable for gallbladder carcinoma patients at advanced stage in terms of predicting prognosis.

Objective:Explore decoy oligonucleotide (ODN) technology targeted blocking STAT3 activation way effects on colorectal cancer HT29 cell growth,to provide experimemt basis for gene therapy of colorectal cancer.Methods:Using decoy ODN in vitro transfect colorectal cancer HT29 cell line,to targeted blocking STAT3 activation way.Fluorescence microscope and flow cytometry detect transfection conditions and efficiency,and MTT method detect the cell growth inhibition,Realtime RT-PCR and Western blotting test STAT3 in cells,the Bcl-xl and Caspase3 mRNA and protein expression.Results:STAT3 decoy ODN can efficient transfection into colorectal cancer cells,and is due to the nucleus.HT29 cell in the STAT3 decoy ODN,growth inhibition rate increased significantly,and mRNA and quantity of protein expression of STAT3 significantly reduce (P＜0.05),while caspase3 increase significantly (P＜0.05).Conclusion:Named Decoy ODN targeted after blocking STAT3 activation way,which can effectively cut colorectal cancer cells HT29 STAT3 gene expression,and inhibit the growth of the cells.The mechanism may be related to lower the expression of STAT3 and the Bcl-xl and Caspase3.

OBJECTIVE:To investigate the characteristics of drug release and the factors affecting the in vitro dissolubility of diclofenac potassium double-layer tablets(DPD).METHODS:UV-spectrophotometry and rotating basket method in the pha-rmacopeia of China 2000 edition were used to determine the in vitro dissolubility of DPD and Higuchi equation was adopeted to simulate the in vitro drug release.The main parameters of dissolution were stastistically analysed.RESULTS:Dissolution parameters of DPD were as follows:T0.3=0.10h,Td=3.30h,T0.9=9.19h.Hardness of tablets did not affect the dissolution rate significantly;pH of dissolution media significantly influenced on the rate.Rotation speed had a significant effect on dissolution action only at the beginning of test.CONCLUSION:DPD has good properties of fast and sustained release.Proper media is the key of in vitro drug release test,however,the ultimate results should be based on in vivo trial.