1.The expression and significance of PPAR ? in chronic hepatitis B tissues
Journal of Chongqing Medical University 2007;0(11):-
Objective:To detect the relation of peroxisome proliferators actived receptor ?(PPAR?)in the hepatic tissue of chronic hepatitis B and explore its significance.Methods:The protein and mRNA expression of PPAR? was detected by means of immunohistochemistry and semi-quantitative RT-PCR in cases of hepatic fibrosis staging S0-S4 of chronic hepatitis B and cases of hepatic hemangioma.The average of A values was obtained by image analysis.Results:There was not obvious correlation between PPAR? level and the hepatic activity index.Positive staining of PPAR? was observed in all of the human liver tissues.The expression of PPAR?in tissues of staging S0 and normal liver was stronger than that in tissues of staging S3 and staging S4(P
2.Effects of preoperative intraarterial infusion chemotherapy on the expression of Smad4 in colorectal carcinoma
Journal of Chongqing Medical University 2003;0(05):-
Objective:To investigate the effect of preoperative intraarterial infusion chemotherapy on the expression of Smad4 in colorectal carcinoma.Methods:15 cases of advanced colorectal carcinoma were treated with preoperative intraarterial infusion chemotherapy,18 cases treated with systemic chemotherapy and 21 cases treated with operation served as the control group.The expression of Smad4 was detected by immunohistochemic S-P method.Result:Among the three groups,the expression level of Smad4 gradually increased(P
3.Clinical analysis on renal cell carcinoma in young adults (a report of 31 cases)
Journal of Chongqing Medical University 2003;0(06):-
Objective:To investigate the clinical features of renal cell carcinoma(RCC) in young adults for improving its diagnosis and treatment.Study was dome on 31 cases at 9 male and 22 female patients were admintted in our hospital. Methods:A total of 447 cases of RCC admitted in our hospital from January 1990 to December 2006 were retrospectively studied.Among them,the clinlical data of 31 cases of RCC in young adults were analyzed and compared with those of the common RCC patients. Results:Of the 31 cases,9 cases were male and 22 cases female,with the ration as 1∶2.44.Tumors were discovered incidentally in 10 cases(32.3%) and symptomatically in 21 cases(67.6%);there were 3 cases(9.7%)of small renal cell carcinoma and the carcinoma diameter of the other 28 cases were beyond 3cm. It had no significant difference when comparing the 5-years survial rate of renal cell carcinoma in young adults(53.6%) with that of RCC in common cases(57.4%). Conclusion:It is important for the young people to do health examination and B type ultrasound is a convenient and effective way for them. Radical nephrectomy would still be the main treatment modality and NSS could be an alternative in suitable young patients.
4.Study of the relationship between Epstein-Barr virus infection and abnormal activation of B-lymphocytes in systemic lupus erythematosus
Chinese Journal of Rheumatology 2009;13(6):394-396
Objective To investigate the role of Epstein-Barr virus(EBV) infection on the abnormal activation of peripheral B-iymphocytes of systemic lupus erythematosus (SLE) patients,and the relationship between EBV infection and the abnormal activation of B-lymphocytes and SLE activity is explored. Methods BamH I-W genome in EBV DNA of 52 SLE patients and 23 controls were examined by PCR-Southern blotting. The level of ANA and EBV VCA-IgM in sera was measured by ELISA. The expression of CD19+ and expression rate of CD19+ and CD23+/CD19+ in EBV-positive SLE patients was higher than that of EBV-negative patients. Meanwhile,the fluorescence signal of CD23 in B cell of EBV-positive SLE patients was stronger than that of EBV-negative ones. Conclusion EBV infection may be related to abnormal activation of B-lymphocytes.EBV may infect and activate B-lymphocytes by up regulating the expression of CD23 of B-lymphocytes. The abnormal activation of B-lymphoeytes is associated with SLE activity.
5.Correlation Between Cervical Cancer and Cervical Virus Infection
Chinese Journal of Nosocomiology 2006;0(08):-
OBJECTIVE To investigate the diagnostic effect of cervical cytology test combined with high-risk human papilloma virus detection in the diagnotic and screening tests for cervical cancer and its precancerous lesion.METHODS To screen 590 women by conventional Papanicolaou smear test combined with oncogenic human papilloma virus DNA testing,selecting the abnormalities and high-risks in clinic,and using vaginoscopical biopsy or cervical canals scraping.We diagnosed patients according to histopathology.RESULTS From 590 patients there were no high risk changes when cytology and human papilloma virus(HPV) were negative;the rate of ≥cervical intraepithelial neoplasia(CIN) Ⅱ was 10.1% when cytology(-) and HPV(+);the rate of ≥CIN Ⅱ was 39.39% when cytology(+) and HPV(+);and the rate of ≥CIN Ⅱ was 12.3% when cytology(+) and HPV(-).There were no CIN Ⅲ or even worse.CONCLUSIONS The way of cytology combined with high risk HPV test is accurate,swift and sensitive,it can be used into screening cervical cancer and its precancerous lesion,futhermore,the screening interval can be lengthened if the results are negative.
6.Causes, Influences and Ethical Countermeasures of Difficult Registration
Modern Hospital 2016;16(10):1500-1502
This paper analyzes the causes and influences of difficult registration from the perspective of ethics , and proposes solutions to the problem of difficult registration , and leads patients to see the doctor scientifically and rationally , and insists on “people first” and enhances hospital management .The government should perform its responsibilities , effectively protect the equal right of citizens to see the doctor and make concerted efforts to solve the problem of difficult registration .
7.Functions of domestic interrogation mobile medical APP
Chinese Journal of Medical Library and Information Science 2015;24(12):63-65
After the commonly used domestic interrogation mobile medical APP were classified, the functions of different APP were analyzed according to the experiences of their users, and their development was prospected.
8.The Causes, Effects and Ethical Countermeasures for Medical Violence
Chinese Medical Ethics 2015;(5):692-694
In ethical perspective , the author analyzed the medical cause of violence and influence , and propo-ses ways to prevent medical violence is:advocating the spirit of medical humanities , implementing humanistic care;to strengthen the construction of hospital ethics system , improve medical service quality;to implement the functions of the government , maintaining the authority of the law; to strengthen the construction of citizen moral ethics and social responsibility together , in order to jointly build the doctor -patient harmonious medical environment .
9.Compilation of New-edition Military Medical Metrology Tree Graph
Chinese Medical Equipment Journal 1993;0(06):-
The new-edition Military Medical Metrology Tree Graph is involved in this paper.The fundamental,purpose and main ideas of the graph are introduced.The solutions to some problems are also put forward.
10.Principle and Testing of Electronic Blood-Pressure Meters(Oscillometric Method)
Chinese Medical Equipment Journal 2004;0(08):-
The working principle of oscillometric method are introduced in Indirect Blood Pressure(INBP) measurement,and the various algorithms in this field are compared.In addition,the framework of INBP simulator used to test or calibrate electronic blood-pressure meters is described.The restriction of the simulator to calibrate INBP is also discussed.