1.Clinical effects of recombinant human granulocyte-macrophage colony-stimulating factor(rh GM-CSF) in patients with leukopenia after cancer chemotherapy.
Jae Sung HONG ; Soo Kyung PARK ; Kwan Hoon LEE ; Sy Sueng RHU ; Jae Keun JUNG ; Sung Eun NAMGOONG ; Seung Jo KIM ; Hun Young LEE
Korean Journal of Obstetrics and Gynecology 1993;36(7):2993-2999
No abstract available.
Drug Therapy*
;
Humans*
;
Leukopenia*
2.Repeated fever with cytopenia.
Lei GAO ; Yu Jie WANG ; Miao Xia HE ; Gu Sheng TANG ; Xiao Xia HU ; Dan YANG ; Jian Min WANG ; Jian Min YANG
Chinese Journal of Hematology 2019;40(11):962-964
Anemia
;
Fever
;
Humans
;
Leukopenia
;
Thrombocytopenia
3.A case of Methimazole-Induced Cholestatic Jaundice With Agranulocytosis.
Sang Gu KANG ; Jong Oh BAE ; Eun Young LEE ; Seong Min LIM ; Sang Kun CHO ; Ji Hye KIM ; Sun Kyung SONG
Journal of Korean Society of Endocrinology 2005;20(5):519-523
Methimazole is a widely used and generally well-tolerated antithyroid agent. Adverse reactions occur in 1~5% of patients taking methimazole medication, but these are most commonly transient, benign leukopenia and a skin rash. Severe cholestatic jaundice, combined with agranulocytosis, has been known as a rare complication. Herein, a case of methimazole induced cholestatic jaundice, with agranulocytosis, is reported.
Agranulocytosis*
;
Exanthema
;
Humans
;
Jaundice, Obstructive*
;
Leukopenia
;
Methimazole
4.Two Cases of Reversible Neutropenia Associated with Olanzapine-Valproate Combination Treatment.
Shi Hyun KANG ; Jung Keun OH ; Jong Il LEE ; An Kee CHANG
Journal of Korean Neuropsychiatric Association 2010;49(6):653-656
The novel antipsychotic, olanzapine, has structural and pharmacological properties similar to clozaine. Antipsychotic drugs, as well as mood stabilizers, can cause neutropenia, which can progress to life-threatening agranulocytosis if the medication is not discontinued. We report two cases of reversible neutropenia associated with a olanzapine-valproate combination treatment. This report suggests that patients treated with the combination of olanzapine and valproate should be monitored for the occurrence of leukopenia and neutropenia.
Agranulocytosis
;
Antipsychotic Agents
;
Benzodiazepines
;
Humans
;
Leukopenia
;
Neutropenia
;
Valproic Acid
5.Neutropenia with Multiple Antipsychotics Including Dose Dependent Neutropenia with Lurasidone.
Clinical Psychopharmacology and Neuroscience 2017;15(4):413-415
Antipsychotic-induced agranulocytosis is a significant side effect that is known to occur with most of the antipsychotic medications. It usually resolves once the medications are stopped and patients are able to be switched over to another antipsychotic medication. Lurasidone has not been reported to cause leukopenia and neutropenia. This case report is of a patient with a past history of risperidone induced-aganulocytosis developing dose related leukopenia and neutropenia with lurasidone.
Agranulocytosis
;
Antipsychotic Agents*
;
Humans
;
Leukopenia
;
Lurasidone Hydrochloride*
;
Neutropenia*
;
Risperidone
6.The Clinical Effect of Recombinant Human Granulocyte-Colony Stimulating Factor to the Leukopenia During Chemotherapy in the Patients with Gynecologic Malignancies.
In Suk CHOI ; Jung Mi SON ; Hyun KIM ; Gun Sang YOO ; jun Mo AN ; Won Gue KIM ; Un Dong PARK
Korean Journal of Gynecologic Oncology and Colposcopy 1996;7(2):100-109
An increase in the dose of chemotherapy enhances the response of many experimental and clinical cancers, but the extent of chemotherapy dose escalation and repeated use is often limited by myelosuppression. The side effects of chemotherapy including bleeding and infection due to myelosuppression have resulted in delayed therapy and a reduction in the therapeutic dose, therefore it is necessary to overcome myelosuppression especially leukopenia in patients with gynecologic malignancies who recieved chemotherapy. This study is undertaken to investigate the clinical effects of rhG-CSF(recombinant human Granulocyte-colony stimulating factor) in 29 patients with gynecologic malignancy who recieved chemotherapy. It was given at a dose of 100 microgram bid/day subcutaneously until significantly increase of leukocyte count in leukopenic patient. The results showed, the rhG-CSF has significantly increased the number and function of leukocyte. The use of rhG-CSF was effective and useful to treat chemotherapy induced leukopenia and to accelerate the recovery from this complications.
Drug Therapy*
;
Hemorrhage
;
Humans*
;
Leukocyte Count
;
Leukocytes
;
Leukopenia*
7.The Comparison of the Efficacy and Side Effects between M-VAC and GC Chemotherapy for Advanced or Metastatic Urothelial Carcinoma Patients with a Good Performance Status.
Hosup KWAK ; Sunghyup CHOI ; Jae Il CHUNG
Korean Journal of Urology 2007;48(12):1229-1235
PURPOSE: We wanted to compare the efficacy and toxicity of chemotherapy with methotrexate, vinblastine, adriamycin, cisplatin(M-VAC) versus gemcitabine and cisplatin(GC) for patients with advanced or metastatic urothelial carcinoma. MATERIALS AND METHODS: Forty-nine patients diagnosed with advanced urothelial cell carcinoma and who were started on chemotherapy were divided into two groups. All of them had a 0-1 Eastern Cooperative Oncology Group performance status. 19 patients received M-VAC chemotherapy and 30 patients received the GC regimen. Among them, the subjects who completed more than 3 cycles of their recommended formula (13/19 for M-VAC, 28/30 for GC) were included in this study. They were evaluated for their overall response rate, the 5-year survival rate, toxicities and the drop-out rate. RESULTS: The overall response rate and median survival period of the M-VAC and G-C groups were 38%(5/13 cases) and 46%(13/28 cases), and 16.7 months and 43.9 months, respectively. The 5-year survival rates in the two groups were 10% in the M-VAC group and 46% in the G-C treated group(p=0.013). The main hematologic complication was leukopenia and this occurred in 10/19 patients and more than grade 3 leukopenia was noted in 4/10 patients in the M-VAC group and in 19/30 patients and more than grade 3 was noted in 10/19 patients in the GC group.The common non-hematologic side effects between the two groups were nausea/vomiting(84.2% vs 47.7%), alopecia(47.4% vs 26.7%), diarrhea(15.8% vs 16.7%), and nephrotoxicity(15.8% vs 6.7%), respectively. The drop-out rates were 31.6% in the M-VAC group and 6.7% with the GC group. CONCLUSIONS: For patients with a good performance status with advanced or metastatic urothelial carcinoma, GC chemotherapy is more effective and it has more tolerable toxicities than does the M-VAC regimen.
Doxorubicin
;
Drug Therapy*
;
Humans
;
Leukopenia
;
Methotrexate
;
Survival Rate
;
Vinblastine
8.Three Cases of Anticonvulsant Hypersensitivity Syndrome Associated with Lamotrigine.
Yong Won CHO ; Hyung LEE ; Sung Il SOHN ; Doo Kyo JUNG ; Jeong Geun LIM ; Sang Doe YI
Journal of the Korean Neurological Association 2002;20(1):79-81
Among the various side effects of anticonvulsant medication, the anticonvulsant hypersensitivity syndrome (AHS) is underrecognized. This condition developed frequently with aromatic anticonvulsants, but with new antiepileptic drugs as well. We experienced three lamotrigine-induced AHS cases with symptoms such as fever, rash, leukopenia, eosinophilia and lymphadenopathy, which subsided after withdrawal of lamotrigine.
Anticonvulsants
;
Eosinophilia
;
Exanthema
;
Fever
;
Hypersensitivity*
;
Leukopenia
;
Lymphatic Diseases
9.A Case of Olanzapine-Induced Neutropenia.
Journal of Korean Neuropsychiatric Association 2005;44(1):120-124
The author reported a case of a 44-year-old man who developed leukopenia and neutropenia during pharmacological therapy with olanzapine for schizophrenia. He was found to have a significantly decreased WBC level (1.6x109/L, neutrophils 34%) without any signs of medical conditions such as infection, hematologic disorder, or nutritional deficiency. The patient did not use any other neuroleptics or drugs that could induce hematological toxicity. The author concluded that the neutropenia in this case was attributed to the use of olanzapine medication. The author also tried to review current literatures on untoward hematological effects caused by olanzapine therapy. Clinicians may need to be cautious about the potential risk for hematological toxicity caused by olanzapine medication. Patients who were treated with olanzapine should be monitored for WBC level, especially in those patients with previous history of drug-induced neutropenia/agranulocytosis, or those are on high-dose olanzapine.
Adult
;
Antipsychotic Agents
;
Humans
;
Leukopenia
;
Malnutrition
;
Neutropenia*
;
Neutrophils
;
Schizophrenia
10.A Case of Atypical Kawasaki Disease with Severe Neutropenia.
Eun Ji KWON ; Seung Ik LEE ; Min Seob SONG ; Geun Ha CHI ; Chul Ho KIM
Journal of the Korean Pediatric Cardiology Society 2007;11(2):138-141
Leukocytosis and neutrophilia is common during the acute phase of Kawasaki disease whereas leukopenia is not common and severe neutropenia is rare. Severe neutropenia is defined as absolute neutrophil count less than 500/mm3. There are only few publicatons reporting of atypical Kawasaki disease with severe neutropenia. We report a case of atypical Kawasaki disease with severe neutropenia.
Leukocytosis
;
Leukopenia
;
Mucocutaneous Lymph Node Syndrome*
;
Neutropenia*
;
Neutrophils