Response Evaluation Criteria In Solid Tumors (RECIST) and WHO Criteria are the most in portant ones.There are some differences between them,in one word,RECIST is better than WHO Criteria when implemented in clinic.However,there are some shortcomings in RECIST.Improvement is needed to make the criteria more and more Derfect and scientific.

Objective: To investigate the associations of single nucleotide polymorphisms(SNP) on bactericidal/permeability-increasing protein(BPI) and lipopolysaccharide-binding protein(LBP) with the complication of sepsis. Methods: The SNP genotypes of BPI Lys216Glu,PstⅠin intron 5,G545C,LBP Cys98Gly and Leu436Pro were examined by restriction fragment length polymorphism PCR(PCR-RFLP).Results:The rate of BPI Lys216Glu G/G genotypes and G-alleles in patients with sepsis were significantly higher than that of volunteers.The rate of BPI Lys216Glu G/G genotypes and G-alleles in nonsurviving patients were significantly higher than that of survivor patients. Conclusion: The BPI Lys216Glu G-allele may be associated with the high risk of sepsis.

Objective To investigate the expression period of bFGF and the correlation between the M?ller cells in retina and the increasing of bFGF expression in diabetic rabbits.Methods Sixteen rabbits were divided randomly into normal control and diabetic groups.After the models of diabetic rabbits were set up,the rabbits were breeded for 7 weeks.The immunofluorescence double labeling method and laser confocal microscopy were used to observe the ratina of the diabetic rabbits and the position fixing of bFGF was studied.Results In normal control group,the structure of each layer of retina was clear,the cell lined up tightly and regularly with normal shape,the location with red fluorescence was M?ller cells signaled with GFAP,labeled with bFGF,only on capillary basement membrane the red fluorescence could be found.In diabetic group,the structure of each layer of retina was clear,the cells of INL and GCL lined up loosely,the intercellular space increased,there was no significant difference compared with normal group on cell shape.Labeled with bFGF,the different intensity red fluorescence could be found in each layer cells,double labeled with GFAP and bFGF,the yellow fluorescence could be found.The retinopathy of diabetic rabbit was in BDR stage.The expression of bFGF increased in this stage.The bFGF and GFAP coexpressed in M?ller cells.Conclusion The bFGF begins to express in the M?ller cells from the BDR stage.

This paper describes the present status and existing problems of clinically monitoring blood drug concentrations, in hospital pharmacy in Shanxi Province. The ways to solve these problems are suggested.

The series of 441 cases of orbital tumor comprised 245 males and 196 females whose age ranged from 6 months to 60 years.The tumors of high incidence in order of impor- tance were hemangioma,dermoid cyst,mu- cocele,meningioma,and optic neuroglioma. A modified surgical approach was mode for complete removal of tumors located in the poste,ronasal aspect of the orbit.Besides, other approaches to the orbital apex were also attempted in addition to regular routes.

The accommodating intraocular lens (AIOL) is designed to simulate the accommodation of the crystalline lens and satisfy patients by its ability to focus on an object at any distance independent of spectacles.However,near vision in the short-term or long-term future of some patients with AIOLs is not good in clinical practice and there is still no consistent conclusion as to whether they can restore sufficient accommodation.Most clinical evaluations of AIOL performance have been based on visual function, such as the testing of near visual acuity and subjective measurements of accommodation,but these tests may not determine whether the lenses are actually working according to the principle of their design.With the rapid development of imaging technologies, the performance of AIOLs can be observed from the perspective of morphology.This article described the biometry of the anterior segments in the subjects with AIOL during accommodation in order to understand the actual clinical effects of AIOLs.

OBJECTIVE To develop technique of central vein catheterization by external jugular vein puncture under ultrasound guidance.METHODS A total of 224 patients with central vein catheterization by external jugular vein puncture were randomized into two groups: the control group was treated by routine manipulation and observed blood vessels by macroscopic observation;the patients from the observation group were placed catheters with the assist of ultrasound techniques.To record the one time achievement ratio of catheterization and incidence of phlebitis and thrombus.RESULTS Comparing the two groups,we found the observation group had higher one time achievement ratio of catheterization and lower incidence of phlebitis and thrombus than that of the control group.And there were statistical significances between the two groups(P

BACKGROUND: Lot of researches has been made on investigating the influence of neurturin(NTN) on dopaminergic neurons,motor neurons,sensory neurons and sympathetic neurons in respect of its enhancing survival and neuroprotective potential. But reports about its influence on cholinergic neurons still remained less.OBJECTIVE: To study the influence of NTN combined with nerve growth factor(NGF) on the survival of NGF receptor positive neurons in vitro.DESIGN: A repeated measurement and experimental study. based on cell model.SETTING: Department of anatomy in a university.MATERIALS: This study was carried out at the Human Anatomical Department of Guangzhou Medical College between September 2001 and June2002. Neonatal SD rats were adopted,DMEM/F12 culture medium supplemented with 20 g/L additive without serum were filtered and sterilized for cell culture.METHODS: Rats were divided into four groups: NGF group,NTN group,NGF + NTN group and control group. Cells of the former three groups were cultured with NGF,NTN and NGF + NTN of 100 μg/L respectively,which were replaced by culture medium in control group. Cholinergic neurons derived from neonatal rat basal forebrain were primary cultured for observing the influence of NTN,NGF on their survival by using immunohistochemical combined imaging analysis method.MAIN OUTCOME MEASURES: The survival rate and growing state of NGFR positive neurons derived from forebrain of neonatal rats when cultured for 4 days and 8 days in vitro.RESULTS: In 4-day culture,indexes of NTN group were significantly different from control group( P ＜ 0. 05 ),and indexes of NGF + NTN group were better than those of NGF group or NTN group( P ＜ 0. 05); in 8-day culture,all indexes except the number of neuronal processes in NTN group were similar to control group( P ＞ 0.05),and indexes of NGF + NTN group were still better than that of NGF group or NTN group( P ＜ 0. 05); but the number of NGF-R positive neuronal processes in NTN group was more that that in NGF group ( P ＜ 0. 05).CONCLUSION: NTN has neurotrophic effect on NGF-R positive neurons of neonatal rat basal forebrain in vitro by relatively shorter acting time,and the number of neuronal processes induced by NTN is stronger than NGF; Moreover NTN combined with NGF exerts better effect than NTN or NGF alone in vitro.

ObjectiveTo probe the alterated characteristic of reactive oxygen species, reduce glutathione and glutathione peroxidase (GSH - PX) in serum of persons. Method Under the controlled load by treadmill, correlative indexes were determined during resting state, sub - maximalload and exhaustive exercise. ResultROS level of serum increased significantly during sub- maximal load compaired with that of restingstate. The ROS level during exhaustive exercise was higher than that of sub - maximal load( P ＜0. 01 ) . GSH content and GSH - PX activity de-creased significantly( P ＜0. 001 ). GSH content and GSH - PX reactivity decreased significantly( P ＜0. 001 ) during sub - maxiaml load and in-creased after exhaustive exercise which was still lower that of resting state. Conclusion ROS increased with the enhancement of exercise intensityand the time. GSH and GSH - PX showed a significant decrease in content and activity respectively followed by apparent enhancement.

Endovascular coil embolization has become an important way because of its advantages of less trauma and quick recovery.However,long-term follow-up studies have shown that the recurrence rate of aneurysm after coil embolization is much higher than that of the surgical clipping.It is mainly associteed with the factors such as incomplete packing coil compression and aneurysm regrowth.This article reviews the factors influencing intracranial aneurysm recurrence after endovascular coil embolization.