This paper describes the present status and existing problems of clinically monitoring blood drug concentrations, in hospital pharmacy in Shanxi Province. The ways to solve these problems are suggested.

The series of 441 cases of orbital tumor comprised 245 males and 196 females whose age ranged from 6 months to 60 years.The tumors of high incidence in order of impor- tance were hemangioma,dermoid cyst,mu- cocele,meningioma,and optic neuroglioma. A modified surgical approach was mode for complete removal of tumors located in the poste,ronasal aspect of the orbit.Besides, other approaches to the orbital apex were also attempted in addition to regular routes.

The accommodating intraocular lens (AIOL) is designed to simulate the accommodation of the crystalline lens and satisfy patients by its ability to focus on an object at any distance independent of spectacles.However,near vision in the short-term or long-term future of some patients with AIOLs is not good in clinical practice and there is still no consistent conclusion as to whether they can restore sufficient accommodation.Most clinical evaluations of AIOL performance have been based on visual function, such as the testing of near visual acuity and subjective measurements of accommodation,but these tests may not determine whether the lenses are actually working according to the principle of their design.With the rapid development of imaging technologies, the performance of AIOLs can be observed from the perspective of morphology.This article described the biometry of the anterior segments in the subjects with AIOL during accommodation in order to understand the actual clinical effects of AIOLs.

Objective: To investigate the associations of single nucleotide polymorphisms(SNP) on bactericidal/permeability-increasing protein(BPI) and lipopolysaccharide-binding protein(LBP) with the complication of sepsis. Methods: The SNP genotypes of BPI Lys216Glu,PstⅠin intron 5,G545C,LBP Cys98Gly and Leu436Pro were examined by restriction fragment length polymorphism PCR(PCR-RFLP).Results:The rate of BPI Lys216Glu G/G genotypes and G-alleles in patients with sepsis were significantly higher than that of volunteers.The rate of BPI Lys216Glu G/G genotypes and G-alleles in nonsurviving patients were significantly higher than that of survivor patients. Conclusion: The BPI Lys216Glu G-allele may be associated with the high risk of sepsis.

Objective To investigate the expression period of bFGF and the correlation between the M?ller cells in retina and the increasing of bFGF expression in diabetic rabbits.Methods Sixteen rabbits were divided randomly into normal control and diabetic groups.After the models of diabetic rabbits were set up,the rabbits were breeded for 7 weeks.The immunofluorescence double labeling method and laser confocal microscopy were used to observe the ratina of the diabetic rabbits and the position fixing of bFGF was studied.Results In normal control group,the structure of each layer of retina was clear,the cell lined up tightly and regularly with normal shape,the location with red fluorescence was M?ller cells signaled with GFAP,labeled with bFGF,only on capillary basement membrane the red fluorescence could be found.In diabetic group,the structure of each layer of retina was clear,the cells of INL and GCL lined up loosely,the intercellular space increased,there was no significant difference compared with normal group on cell shape.Labeled with bFGF,the different intensity red fluorescence could be found in each layer cells,double labeled with GFAP and bFGF,the yellow fluorescence could be found.The retinopathy of diabetic rabbit was in BDR stage.The expression of bFGF increased in this stage.The bFGF and GFAP coexpressed in M?ller cells.Conclusion The bFGF begins to express in the M?ller cells from the BDR stage.

Response Evaluation Criteria In Solid Tumors (RECIST) and WHO Criteria are the most in portant ones.There are some differences between them,in one word,RECIST is better than WHO Criteria when implemented in clinic.However,there are some shortcomings in RECIST.Improvement is needed to make the criteria more and more Derfect and scientific.

OBJECTIVE To develop technique of central vein catheterization by external jugular vein puncture under ultrasound guidance.METHODS A total of 224 patients with central vein catheterization by external jugular vein puncture were randomized into two groups: the control group was treated by routine manipulation and observed blood vessels by macroscopic observation;the patients from the observation group were placed catheters with the assist of ultrasound techniques.To record the one time achievement ratio of catheterization and incidence of phlebitis and thrombus.RESULTS Comparing the two groups,we found the observation group had higher one time achievement ratio of catheterization and lower incidence of phlebitis and thrombus than that of the control group.And there were statistical significances between the two groups(P

OBJECTIVE:To provide reference for the development of hospital preparation in our hospital. METHODS:The method of SWOT analysis was applied to analyze competitive strengths,weaknesses,opportunities and challenge about the develop-ment of pharmaceutical preparations in our hospital,and to explore the development strategies of hospital preparation. RESULTS &CONCLUSIONS:The strengths include the prominent specialty characteristics of clinical key subject,a long R&D history,diverse dosage forms and varieties,definite therapeutic efficacy,etc. The weaknesses contain production capacity shrinkage,deficient con-struction of professional team,external exchange and cooperation deficiency,etc. The opportunities contain national health con-sciousness enhancement,hospital preparation included into local medical insurance reimbursement,etc. The threats contain great difficulty to register new preparation and low preparation pricing,etc. It is suggested to rely on advantage resources to enhance clin-ical formulation development,strengthen human resource management and team building,strengthen cooperation and exchanges to enhance research and development,strengthen the meticulous management to improve operational capacity,in order to formulate scientific development strategy.

24 h) was the main cause of high emergent perioperative death rate. There was a rationale for prophylactic surgery.

cholesterol/phospholipid ratio.