Objective To assess the clinical significance of QT interval dispersion (QTd) in the diagnosis and prognosis of early heart damage in patients with severe acute pancreatitis.Methods All patients received complete ECG,There were 58 patients with SAP (the SAP group) and 189 patients with mild acute pancreatitis (the control group).These patients were analyzed retrospectively and 60 normal people were used as the healthy control group.The QT interval were measured respectively in serial 12-lead electrocardiogram and QTd,QTcd were calculated.Result QTd and QTcd were significantly longer in the SAP group than in the MAP group and in the healthy control group (P＜0.01).QTd,QTcd were not remarkably extended in the MAP group than in the healthy control group (P＞0.05).Conclusions QTd and QTcd have clinical values to diagnose and to predict early heart damage in patients with SAP.They might be useful in evaluating the condition of cardiac function in patients with SAP.

Background Monocyte chemoattractant protein-1 (MCP-1) polymorphisms are demonstrated to be significantly associated with the susceptibility to uveitis in recent years,while a consistent conclusion for the association of MCP-1-2518A/G polymorphism and uveitis risk is not reached yet.Objective This study was to comprehensively investigate the correlation between MCP-1-2518A/G polymorphism and uveitis susceptibility.Methods General searches of electronic database including PubMed,Embase,Web of Science,CNKI,VIP,Wanfang database and China biomedical literature database (CBD) were performed to retrieve published case-control studies regarding the association between MCP-1-2518A/G polymorphism and uveitis risk.The data were screened according to the inclusion and exclusion criteria and extracted,and the quality of included studies was evaluated.The pooled odds ratios (OR) with 95％ confidence intervals (CI) were calculated.Publication bias and sensitivity analysis were also assessed.All statistical analyses were conducted with RevMan 5.2 and Stata 12.0 software.Results A total of 8 eligible case-control studies involving 1 197 cases and 1 570 controls were included in the Meta-analysis.The results showed no significant association of MCP-1-2518A/G polymorphism with uveitis susceptibility in the G vs.A,GG vs.AA and GG vs.AG+AA models (all at P＞0.05).MCP-1-2518A/G polymorphism was found to be significantly associated with uveitis risk in the GG+AG vs.AA model (P =0.01,OR =1.25,95％ CI:1.06-1.48),while no significant association was found by the sensitive analysis (GG + AG vs.AA:P =0.19,OR =1.16,95％ CI:0.93-1.45).The subgroup analysis by uveitis types revealed that the individuals carrying allele-G or GG genotype harbored a significantly increased risk for anterior uveitis (G vs.A:P=0.01,OR=1.49,95％ CI:1.16-1.90;GG vs.AA:P=0.01,OR=2.09,95％ CI:1.21-3.61;GG+AG vs.AA:P=0.01,OR=1.58,95％ CI:1.12-2.23;GG vs.AG+AA:P=0.01,OR=1.78,95％ CI:1.12-2.83).The individuals with GG+AG vs.AA genotype harbored a significantly increased risk for Behcet's disease (BD) (P=0.04,OR =1.35,95％ CI:1.01-1.79) but not for other types of uveitis (P ＞ 0.05).Additionally,a significantly elevated risk was found in uveitis patients with allele-G or GG genotype in Asian population in the subgroup analysis based on ethnicity (G vs.A:P =0.04,OR =1.15,95％ CI:1.01-1.32;GG vs.AA:P=0.04,OR=1.32,95％ CI:1.02-1.71;GG+AG vs.AA:P=0.01,OR =1.36,95％ CI:1.09-1.70),but that was not found in Caucasians population (all at P＞0.05).Conclusions MCP-1-2518A/G polymorphism is significantly associated with the risk of uveitis in Asian population,anterior uveitis and BD.The allele-G or GG genotype may increase the risk of uveitis in Asian population,anterior uveitis and BD.

Objective To explore the potential mechanism of eliminating fluid-retention by yang-warming and fluid retention-resolving method.Methods Rat model of congestive heart failure (CHF)was estab-lished by intraperitoneal injection of adriamycin.After modeling,the CHF rats were randomly divided in-to model group,group of yang-warming and fluid retention-resolving formula (YWFRR group),and group of yang-warming and fluid retention-resolving formula minus cinnamon twig (YWFRR-CT group). The rats of YWFRR group were intragastrically administered (i.g.)YWFRR at the dose of 12 g/kg once daily for consecutive four weeks,and those of YWFRR-CT were i.g.YWFRR-CT at the dose of 10 g/kg once daily for four weeks,at the same time,the rats of model group and blank group took no medication treatment.Then the serum level of brain natriuretic peptide (BNP)and protein expression of aquaporin-2 (AQP2)in renal tissue were determined.Results Compared with the blank group ,the serum con-tent of BNP in model group increased significantly and the expression of AQP2 in renal tissue decreased significantly (P <0.05 or P <0.01).The contents of serum BNP were both lower in YWFRR group and YWFRR-CT group than that of model group,and the expression of AQP2 higher.Conclusion The method of yang-warming and fluid retention-resolving could decrease the serum content of BNP and upreg-ulate the expression of renal AQP2 of CHF rats.

Patients with severe trauma require an extremely timely treatment and transfusion plays an irreplaceable role in the emergency treatment of such patients. An increasing number of evidence-based medicinal evidences and clinical practices suggest that patients with severe traumatic bleeding benefit from early transfusion of low-titer group O whole blood or hemostatic resuscitation with red blood cells, plasma and platelet of a balanced ratio. However, the current domestic mode of blood supply cannot fully meet the requirements of timely and effective blood transfusion for emergency treatment of patients with severe trauma in clinical practice. In order to solve the key problems in blood supply and blood transfusion strategies for emergency treatment of severe trauma, Branch of Clinical Transfusion Medicine of Chinese Medical Association, Group for Trauma Emergency Care and Multiple Injuries of Trauma Branch of Chinese Medical Association, Young Scholar Group of Disaster Medicine Branch of Chinese Medical Association organized domestic experts of blood transfusion medicine and trauma treatment to jointly formulate Chinese expert consensus on blood support mode and blood transfusion strategies for emergency treatment of severe trauma patients ( version 2024). Based on the evidence-based medical evidence and Delphi method of expert consultation and voting, 10 recommendations were put forward from two aspects of blood support mode and transfusion strategies, aiming to provide a reference for transfusion resuscitation in the emergency treatment of severe trauma and further improve the success rate of treatment of patients with severe trauma.