Electromyography ; Humans ; Occupational Health

Objective:To investigate the risk factors of preterm premature ruPture of membrane(PPROM) and their pregnancy outcomes.Methods:The clinical data of 95 cases of patients with PPROM admitted and treated in our hospital from October 2013 to July 2016 were collected,which were divided into two groups,observation group(gestational week 28-33 +6 weeks) and control group(gestational week 34-36 +6 weeks).The risk factors of PPROM,delivery method and pregnancy outcomes were analyzed.Results:Genital tract infection was the main risk factor of PPROM(33.68％).of the incidences of cesarean delivery,neonatal asphyxia,neonatal infections and neonatal death in observation group were significantly higher than those of control group,the differences were statistically significant(P ＜ 0.05).The intrauterine infection and puerperal infection rates of observation group of were higher than those of control group,but differences were not statistically significant (P ＞ 0.05).Conclusions:Reproductive tract infections is the most important risk factor of PPROM.The purpose of active treatment including tocolytic therapy and prevention of infection for the patients with PPROM less than 34 weeks is to prolong the gestational weeks,to reduce the rate of neonatal complication,and to improve the pregnancy outcome.

Objective:To study the expression of Pleiotrophin and Midkine protein in endometrium of endometriosis and its clinical significance.Methods:Expressions of Pleiotrophin and Midkine protein were examined by immunohistochemical staining method in 30 endometrial samples of endometriosis(study group) and 29 endometrium of uterine fibroid(control group).Result:Pleiotrophin protein mainly expressed in the membrane and plasma of glandular epithelium of endometrium.Midkine protein mainly expressed in the plasma of grandular epithelium of endometrium and expressed in nuclei in some samples.The expression of Pleiotrophin and Midkine protein in endometriosis was significantly higher than that in the control group(P

Aging ; Arteriosclerosis ; pathology ; Blood Vessels ; pathology ; Cellular Senescence ; Humans ; Medicine, Chinese Traditional

Diabetes Mellitus, Type 2 ; drug therapy ; Humans ; Hypoglycemic Agents ; therapeutic use ; Non-alcoholic Fatty Liver Disease ; drug therapy

Nonunion or delayed union remains one of the major complicatio ns of fractures. Repair of fractures involves a sequence of dynamic events which ultimately restore the integrity of bone and its biomechanical properties, incl uding such methods as surgery, internal fixation, bone grafting, external fixati on, electrical stimulation, ultrasound, and high-energy extracorporeal shock wa ve. The preferred management of nonunion and delayed union is autologous bone gr afting. However, the supply of suitable bone is limited and it often results in additional morbidity to the donor site. Recently some advances have been made in the therapeutic principle for nonunion or delayed union. It is aimed at providi ng non-invasion, less complication, and safe treatment. This article introduces the development of some effective and safe therapies for nonunion or delayed un ion.

In this paper, barcode technique is combined with laboratory information system to improve the degree of automation in laboratory. Barcode stuck to specimen collected, such routine laboratory operations are finished according to barcode as specimen sorting, data transmission, two-way communication of analyzing machine, results verifying, reports inquiring, specimen keeping et al. As the only specimen identification, barcode is used to realize two-way communication between analyzing machine and it, thus laboratory workflow is simplified. The application of barcode technique to clinical laboratory improves work efficiency, result reliability and degree of automation greatly. It is the development direction in laboratory in the future.

Objective To compare the clinical curative effect between sequential therapy and triple therapy for helicobacter pylori positive peptic ulcer.Methods 92 patients with peptic dcer were randomly divided into the observation group and the control group,46 cases in each group.The observation group was treated with sequential therapy,control group with triple therapy.The two groups were observed and compared in helicobacter pylori eradication rate,ulcer healing and relief of symptoms.Results After 4 weeks treatment,the observation group Hp clearance rate was 93.5％ (43/46),ulcer healing rate 91.3％ (42/46),the control group were 73.9％ (34/46),78.3％(36/46),two groups had significant differences(x2 =2.714,3.028,all P ＜ 0.05) ;observation group after treatment of symptomatic integral average (0.94 ± 0.21),and the control group (0.92 ± 0.17) divided the difference was not statistically significant (t =0.483,P ＞ 0.05).Conclusion The sequential therapy on helicobacter pylori positive peptic ulcer curative effect is remarkable,and can be more effective in the eradication of helicobacter pylori infection,promote ulcer healing.

The paper introduces using MedlineR to carry out data mining from Medline, for observing the gene relation, and using Pajek to realize the visualization of the results. Practice proofs that MedlineR could help researchers come up with assumptions in the field that they are interested in, and get a visual fingerprint. These results are the bases to go to more complex literature data mining and an important supplementary to experimental methods.

OBJECTIVE:To prepare zolmitriptan-diclofenac microemulsion,and conduct quality evaluation and in vitro trans-dermal study. METHODS:Using solubility and microemulsion area in pseudo-ternary phase diagram as indexes,the types of oil phase and mixed emulsifier ratio of zolmitriptan-diclofenac microemulsion were screened;the microemulsion quality was inspected using particle size,Zeta potential,appearance and stability. HPLC was used to measure the contents of zolmitriptan and diclofenac. Transdermal diffusion test instrument was used,2 g microemulsion was smeared in cuticle of extracouporeal rats'skin,and cumula-tive transdermal rate in 24 h was determined. RESULTS:The microemulsion formulation was as follow as 10% oil phase(octanoic acid triglyceride),25% mixture emulgator [polysorbate 80-brij 97 (1:1)],8.3% propylene glycol and 25 mg zolmitriptan,1.25 mg diclofenac,and water adding to 100 mL. The average particle size of prepared microemulsion was(28.2±2.5)nm,Zeta poten-tial was(-3.25±0.33)mV,the appearance was rounding;the microemulsion showed no stratification or flocculation at room tem-perature after placed for 1 month. Contents of zolmitriptan and diclofenac were 0.248 mg/mL,12.46 mg/mL(n=3);24 h cumula-tive transdermal rates were 80%,75%. CONCLUSIONS:Zolmitriptan-diclofenac microemulsion is prepared,and its in vitro trans-dermal ability is good.