Objective To observe the efficacy of bioelectric stimulation of the pelvic floor combined with acupuncture in treating detrusor urine weakness after transurethral resection of the prostate (TURP) in patients with prostate hyperplasia.Methods Forty-seven cases with detrusor urine weakness after TURP were randomly divided into an experimental group and a control group.All of the patients received routine bladder function training and medication.In addition,patients in the experimental group were treated with bioelectric stimulation of the pelvic floor and with acupuncture.The differences between the two groups were compared using the International Prostate Symptom Score (IPSS),maximum urine flow rate (MFR),average flow rate (AFR),detrusor pressure at peak flow (PdetQmax) and residual urine volume in the bladder.Results No significant difference was found between the two groups before treatment,but at two weeks after treatment MFR,AFR and PdetQmax were significantly higher in the experimental group than in the control group,and residual urine volume and IPSS were significantly lower.Conclusion Bioelectric stimulation of the pelvic floor combined with acupuncture is more effective than routine bladder function training and medication alone for alleviating detrusor urine weakness after TURP.

OBJECTIVE:To establish the quality standard of Tangkang capsule. METHODS:Momordica charantia L. and Euonymus alatus(Thunb.)Sieb.,the main ingredients in Tangkang capsule including were identified by TLC, meanwhile, the content of total Momordica charantian saponin was determined by UV-Vis. RESULTS: The TLC spots were clear and the separation degree was good. The linear range of Ginsenoside Rg1 was 72～252 ?g(r=0.999 7) with average recovery rate at 100.68% (RSD=1.43%,n=6). CONCLUSION: The established quality standard can be used for the quality control of this Tangkang capsule.

Humans ; Occupational Exposure ; Railroads

Objective: to study the relationship between immune complex(IC)and the origin of atherosclerosis(AS),and to evaluate the simvastatin's potential effect on immunomodulation. Methods: Thirty eight truebred New Zealand rabbits were randomly divided into four groups: control group,high-cholesterol fed group,simvastatin-protecting group and simvastatin-treatment group.the structural change of artery and the deposit of IC(and their classes)in plaque lesions of AS were analyzed with hematoxylin and eosin stain and immunohistochemistry. Results: plaque lesions of AS were obvious after 8-weeks high-cholesterol feeding.With the development of AS,the IC of IgG accumulated in plaque lesions,while the IC of IgM did not.The immunohistochemical stain was stronger in high-cholesterol feed group than that in the simvastain-intervening groups.The distribution of immune complexes was under the endothelium in the early plaque while mainly localized in the core or the shoulder of mature plaque lesions. Conclusion: The IC of IgG exists in the plaque lesions of AS.The IC is close related to the origin and the progress of AS.Simvastatin can inhibit the formation of IC as well as lowering the lipid levels and regressing the plaque,which maybe related to it's effect on the immunomodulation.

Objective To evaluate the value of retroperitoneal laparoscopic adrenalectomy for benign adrenal tumors.Methods From Mar.2009 to Oct.2011,36 patients with adrenal tumors received retroperitoneal laparoscopic adrenalectomy in the First People's Hospital of Shangqiu.During the operation,3 trocars were introduced into the lumbar region to establish retroperitoneal space.Afterwards,the tumor was removed by using a harmonic scalpel.Results The procedures were successfully completed in 19 cases of adrenocortical adenoma,14 cases of pheochromocytoma,2 cases of adrenal cyst and 1case of adrenocortical carcinoma without blood transfusion.The median operation time was 90 min,ranging from 45 min to 180 min.The median intraoperative blood loss was 76 ml,ranging from 30 ml to 700 ml.Drainage tubes were removed 2 days after the operation and the patients were discharged from hospital 3 to 5 days after operation.2 cases were converted to open surgery ( one because of the adhesion between the tumor and vena cava,the other because of the size (about 6.0 cm) of the tumor).The median follow-up time was 12 months,ranging from 3 to 24 months.One patient showed regional subcutaneous emphysema after the surgery and was cured spontaneously.The patients were followed up for 3 to 24 months with the medium of 12 months.Normal blood pressure was achieved in 30 patients in 3 months,while oral antihypertension drugs were still needed for the other 6 patients (2 patients converted to open surgery included).No regional recurrence or death happened during the follow-up.Conclusion Retroperitoneal laparoscopic adrenalectomy can be a safe and effective choice for adrenal tumors,with advantages of small trama,quick recovery,short postoperative hospital stay etc.

Objective To investigate the effect of laparoscopic surgery on primary aldosteronism (PA).Methods 20 cases of PA treated by laparoscopic surgery from Jul.2009 to Jul.2011 were retrospectively analyzed,among whom 17 cases had adrenocortical adenoma and 3 cases had adrenal cortical hyperplasia.Results The mean surgical time was 63 (35 ～95 )min,the mean intraoperative blood loss was 50( 25 ～ 110)ml,and the mean hospital stay was 5.8 (4 ～ 8)d.Complication during or after surgery happened to 2 patients.They are both with light cutaneous emphysema.During the medium follow-up of 12(6～ 18 )months,serum potassium levels of all patients were normal,and 3 patients with high blood pressure still need hypotensive drug.Conclusion Laparoscopic resection of the whole or partial adrenal tumor is minimally invasive,safe and with confirmed effects,making it the preferred method for PA.

Objective:To investigate the dissdution behavior of Gansukang capsules from different manufactures in two different dissdution media and to provide theoretical basis for evaluating the quality of medicine. Methods:According to the dissolution test con-ditions in Japan’ s “quality of medical drugs information set” and the physicochemical properties of Gansukang capsules, two dissolu-tion media were chosen. The dissolution behavior of Gansukang capsules from 3 manufacturers in pH 6. 8 phosphate buffer (containing 0. 25% sodium lauryl sulfate) and water (containing 0. 25% sodium lauryl sulfate) was determined by the method I in Appendix XC of Chinese Pharmacopoeia Volume II (2010 edition), and the dissolution rate was determined by HPLC-ELSD. Results:The assay dis-played a good linearity over the concentration range of 2. 0-40. 0 mg·ml-1 for oleanolic acid, the recovery of oleanolic acid in pH 6. 8 phosphate buffer and water was above 98%, and Gansukang capsules had the similar property in the two media. The dissolution behav-ior of Gansukang capsules from 3 manufacturers in water was similar to each other, while in pH 6. 8 phosphate buffer, that was signifi-cantly different. Conclusion:As for the dissolution medium for Gansukang capsule, pH 6. 8 phosphate buffer can reflect more differ-ences in the dissolution of products with different batches and from different manufacturers than water. The method is simple, accurate and reproducible in the dissolution determination of the capsules.

Electromagnetic Fields ; adverse effects ; Humans ; Occupational Exposure ; analysis ; Railroads

Objective To investigate the clinical application value of gene chip method for detecting human papilloma virus (HPV) DNA genotype .Methods A total of 372 samples of HPV genotype in the gynecological outpatients department of our hos‐pital from September to December 2015 were collected ,including 22 kinds of genotype(18 types of high risk ,4 types of low risk) , meanwhile all samples were performed thinprep cytologic test(TCT) .Results In 372 samples ,223 cases of HPV gene were detec‐ted with the detection rate of 59 .94% ,194 cases(52 .15% ) of high risk type and 194 cases(7 .80% ) of low risk type were detected ;the abnormal rate of TCT was 44 .08% (including atypical hyperplasia ,low‐grade and high‐grade lesion) ,the atypical hyperplasia was 22 .88% ,the detection rate of high‐grade lesion was 5 .10% and which of low‐grade lesion was 18 .01% .In the cervical lesions showing the lesion beyond inflammation ,multiple infection and cervical lesions had significant correlation (P<0 .05) .Conclusion HPV genotyping has higher clinical application in the cervical lesion screening ,moreover which has good correlation with the cyto‐logical change .Conducting HPV genotyping is beneficial to the early screening of cervical lesions .

Objective:To investigate the cycling stability effect of methoxamine at low dose in cesarean section in order to find the optimal regimen for the prevention and treatment of hypotension during cesarean section. Methods:Totally 200 patients with scheduled cesarean section were selected and randomly divided into the experimental group and the control group with 100 ones in each. The ex-perimental group was anesthetized through L3-4 lumbar-peridural puncture immediately followed by the infusion of methoxamine, and the control group was anesthetized in the same way, and only when the blood pressure was dropped by more than 15%, the infusion of me-thoxamine was given immediately (2-3mg diluted to 20ml). The systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate ( HR) were compared between the two groups at five time points of before spinal anesthesia ( T0 ) , 5 min after spinal anesthe-sia ( T1 ) , 10 min after spinal anesthesia ( T2 ) , 15 min after spinal anesthesia ( T3 ) and the end of the operation ( T4 ) . The umbilical arterial blood gas and the 1-minute Apgar score of the newborn were recorded, and the adverse reactions in the two groups were com-pared. Results:In T1-T3, SBP and DBP in the two groups were significantly lower than those at T0(P<0. 05), and the decrease in the experimental group was more significant than that in the control group (P<0. 05). In T1-T4, HR in the control group was signifi-cantly lower than that in T0 , while HR in the experimental group had no significant difference when compared with that in T0 ( P>0.05), and HR in the control group was significantly lower than that in the experimental group in T1-T3(P<0.05). There were no significant differences in the scores of pH, PO2, PCO2 and Apgar of the newborn between the two groups (P>0. 05). The incidence of adverse reactions in the experimental group was significantly lower than that in the control group (P<0. 05). Conclusion: The prophylactic use of methoxamine through micro pump can maintain the cycling stability of cesarean section with higher reliability and without adverse effects on the newborn.