1.Progress of rituximab therapy on children with refractory nephrotic syndrome
International Journal of Pediatrics 2013;40(6):545-549
Refractory nephrotic syndrome(RNS) is one of the main causes of end-stage renal disease (ESRD) in children,which is also a difficult issue in clinic.Several therapies,including immunosuppressive agents,have been shown to be effective and safe for RNS.It is proved,however,that a substantial number of children are still refractory to treatment despite these therapies.Recently,rituximab as a new immunosuppressant has achieved good results for RNS,and a number of case reports and clinical trials have suggested that rituximab may be effective for children with RNS.This review will analyse the scientific basis for the efficacy and safety of using rituximab in children with RNS.
2.Diagnosis of acute kidney injury and its biomarkers in children
International Journal of Pediatrics 2015;42(6):639-643
Acute kidney injury (AKI)was a common problem in children in clinic.pRIFLE Criteria, AKIN Criteria, KDIGO Criteria are the main classification criteria of AKI.Though serum creatinine is still used as the most common biomarkers for diagnosis of AKI, the sensitivity and specificity is unsatisfactory.In recent years, many potential biomarkers of AKI have been studied in a variety of experimental and clinical settings.This review describes the novel biomarkers of AKI, including cystatin C, neutrophil gelatinase associated lipocalin, interleukin-18 ,kidney injury molecule-1 and liver-type fatty acid binding protein,, which have now made a progress in clinic.
3.Optimal extraction of effective constituents from Radix Polygalae based on central composite design/response surface methodology
Chinese Traditional Patent Medicine 1992;0(03):-
AIM: To optimize the process of extracting effective constituents from Radix Polygalae by central composite design/response surface methodology. METHODS: Independent variables were ethanol concentration,reflux time and solvent fold,dependent variable was extraction rate of senegenin in Radix Polygalae.Linear or nolinear mathematic models were used to estimate the relationship between independent and dependent variables.Response surface methodology was used to optimize the process of extraction.Prediction was carried out through comparing the observed and predicted values. RESULTS: Regression coefficients of binomial fitting complex model was as high as 0.979 0, the optimum conditions of extraction process were 60% ethanol,2.5 hours for reflux,10-fold solvent and 2 times for extraction.Bias between observed and predicted values was-5.93%. CONCLUSION: It shows that the optimum model is highly predictive.
4.Advances in pathogenesis of purpura nephritis in children and the current status of diagnosis and treatment
Chinese Journal of Primary Medicine and Pharmacy 2017;24(16):2544-2547
Henoch Schonlein purpura nephritis is a systemic inflammatory response of systemic vasculitis in anaphylactoid purpura,it is often occurred in childhood with systemic vasculitis reaction.Some patients will develop nephritic syndrome or nephrotic syndrome,even kidney failure,either of which is harmful to the health of children.However,a unified standard for the diagnosis and treatment of purpura nephritis is still lack.Combined with the latest research results,this research intends to review the pathogenesis,clinical diagnosis and treatment of purpura nephritis.
5.The progress of research on influenza A(H1N1)
Chinese Pediatric Emergency Medicine 2010;17(1):85-86
Influenza A(H1N1)virus is a re-mixed strains of human influenza virus genes,avian influenza virus gene and swine influenza virus gene.Influenza A(H1N1)pandemic influenza has spread around the world,which has drawn worldwide attention.In order to early discovery,early diagnosis,early treatment and effective prevention of Influenza A(H1N1),we describe the characteristics of linfluenza A(H1N1)virus,epidemiology,pathogenesis,clinical manifestations,laboratory examination and effective treatment and preventive measures.
6.Effect of probucoi on the vascular endothelial function of old patients with isolated systolic hypertension
Chinese Journal of Primary Medicine and Pharmacy 2006;0(07):-
Objective To evaluate the effect of probucol on endothelium-dependent vasodilatation(i,e.flow- mediated dilation,FMD) function of the old patients with isolated systolic hypertension.Methods In this single- blind study,a total of 64 old pariems with isolated systolic hypertension were randomized to receive conventional an- tihypertensive therapy and probucol (0.5g twice daily,group A,n=33) or receive conventional antihyperrensive therapy(group B,n=31) for 12 weeks.The levels of blood lipid were measured and vascular endothelial function was assessed in the brachial artery by high-resolution ultrasound technique in form of endothelium-dependent vasodi- latation before and after treatment.Results After 12-week treatment,the levels of TC,LDL-C and HDL-C in group A were significantly reduced compared with those before treatment(all P0.05).Flow-mediated dilatation parameters in both groups were obviously improved compared with those before treatment( P
7.Clinical analysis on arthroscopic treatment of osteoarthritis of the knee
Orthopedic Journal of China 2006;0(11):-
[Objective]To evaluate the therapeutic effect of arthroscopic treatment for osteoarthritis of the knee,and explore the factors related to clinical outcome. [Methods]Three hundred and sixty-two patients with knee osteoarthritis were treated by arthroscopic surgery in the 88th hospital from May 2000 to November 2007. Of them,124 patients were followed-up completely. Quantified clinical data were input into computer and analyzed statistically by SPSS 16.0 software. Lysholm score was used to evaluate the therapeutic effect. Lysholm scores before surgery and at follow up were compared with paired t test. Patients were divided into different subgroups according to sex,locking,X -ray grade,arthroscopic grade and surgical methods. Lysholm scores at the final follow up of different subgroups were compared with variance analysis. The factors related to operation outcome were explored by using multiple stepwise linear regression analysis.[Results]One hundred and twenty-four patients were followed up from 7 to 96 months with an average of 39.6 months. Preoperative Lysholm score was (46.10?2.80),the score at follow up was (70.69+2.90),there was significant difference between preoperative score and at follow up (t=9.362,P0.05). The difference was significant between groups whether locking or not (F=10.654,P
8.Effects of joint synovial fluid on tendon-bone healing of the reconstructed ligaments
Orthopedic Journal of China 2006;0(11):-
[Objective]To explore the effects of joint synovial fluid on tendon-bone healing of reconstructed ligament. [Methods]Forty female New Zealand rabbits,aged 6 months,weight 2.5~3.5 kg,were divided into 4 groups randomly.Transfer of semitendinosus tendon to the bone tunnels was performed to make bone-tendon healing model,on the right knee the bone tunnel was not communicated to the joint cavity,in contrast,the bone tunnel on the left knee was connected with synovial fluid.Animals in one group were killed at 8 weeks after operation,bone-tendon healing samples were harvested for biomechanical test.Animals in other three groups were killed at 2,4 and 8 weeks after operation respectively to harvest the samples for histological observation.HE and Masson staining were conducted to examinant histological change.[Results]At 2 weeks after operation,there was no significant difference between non joint synovial fluid group and joint synovial fluid group in bone-tendon interface healing,which were filled with granulation tissue.At 4 weeks postoperatively,interface healing in non joint synovial fluid group was obvious better than that in joint synovial fluid group.Fibroblast cells and cartilage cells increased obviously,and collagen fibers synthesized.At 8 weeks after operation,tendon-bone interface in joint synovial fluid group was filled with connective tissue,the collagen fibers arranged disorderly.In contrast,more compact collagen fibers were seen in non joint synovial fluid group.Interface cell accounts in non joint synovial fluid group were superior to that in joint synovial fluid group at 2,4,8 weeks after operation (P
9.Improvement in Quality Standard of Naoliqing Capsule
China Pharmacy 2001;0(09):-
OBJECTIVE:To improve the quality standard of Naoliqing capsule. METHODS: The Sus scrofa domestica and Achyranthes bidentata in Naoliqing capsule were identified by TLC, and the content of oleanolic acid was determined by HPLC. RESULTS: The characteristic TLC spots of the Sus scrofa domestica and Achyranthes bidentata in Naoliqing capsule were detected. The linear range of oleanolic acid was 0.5~7.5 ?g(r=0.999 6) with an average recovery of 97.43%(RSD=1.94%,n=6). CONCLUSION: The results are conducive to the improvement of the quality standard of Naoliqing capsule.
10.Therapeutic Efficacy of Compound Epidermal Growth Factor Pellicle for Recurrent Oral Ulcer
China Pharmacy 2005;0(17):-
OBJECTIVE:To observe the efficacy of Compound Epidermal Growth Factor Pellicles for recurrent oral ulcer. METHODS: 106 patients with recurrent oral ulcer were randomly assigned to receive Compound Epidermal Growth Factor Pellicles with efficacy-confirmed hospital preparation as control. The clinical efficacy in two groups was compared. RESULTS: The effective rate was significantly higher in patients treated with Compound Epidermal Growth Factor Pellicles than with hospital preparation (control) (89.66% vs. 75.00%,P