Objective]With discussion of stroke machine with depression syndrome and law,we broaden the clinical thinking and improve clinical therapeutic effect.[Methods]Ancient medical books discussion of stroke and depression syndrome were collected,referring to the definition of post-stroke depression in modern medicine,traditional Chinese medicine continued to collect relevant papers in modern treatises,and combined with the experience of the author's departments in the diagnosis and treatment of post-stroke depression.[Outcome]Post-stroke depression in the pathogenesis of disorders with blood and viscera of yin and yang,phlegm and qi stagnation as the standard.Treatment should be given on multi-organs,especially focusing on regulating liver;emphasis interconversion between pathological factors in clinic,adjusting for the first Qi; taking care treatments with acupuncture combined emotions inter-resistance. Through organizing the relevant literature depression after stroke,come to the disease and its treatment of its laws,as well as the clinical treatment of attention points,which can improve clinical outcomes.[Conclusion] The pathogenesis of post-stroke depression is varied, we must analyse the syndrome and law carefully to promote better recovery, and then improve clinical therapeutic effect.

Objective To explore the analgesic effect of ropivacaine and flurbiprofen for patients with secondary upper extremity lymphedema after lymphatic venous anastomosis . Methods A total of 45 cases of lymphatic venous anastomosis under general anesthesia between October 2014 and March 2016 were randomly allocated to 3 groups: ropivacaine group ( group R ) , flurbiprofen preprocessing group (group F1), and flurbiprofen postprocessing group (group F2), with 15 cases in each group.Local infiltration anesthesia was made with 0.2% ropivacaine 10 ml at the incision before the end of operation in the group R .The flurbiprofen 100 mg was intravenously injected at 5 minutes before the induction of anaesthesia in the group F 1 and 5 minutes before the end of operation in the group F 2 .The visual analogue scale ( VAS) scores and the number of patients using analgesics after operation at 1, 2, 6, 12, 24 and 48 h were recorded. Results The rest pain and movement pain VAS scores at postoperative 2 h were lower in the group R than those in the group F1 and F2[rest pain:(3.4 ±0.7) points vs.(4.2 ±0.9) points vs.(4.1 ±1.0) points, F=3.741, P=0.032;movement pain:(3.7 ±0.6) points vs.(4.6 ±0.9) points vs.(4.4 ±1.0) points, F=4.305, P=0.020]. The rest pain VAS scores at postoperative 6 h were lower in the group R than those in the group F 1 and F2 [(2.7 ±0.5) points vs. (3.4 ±0.5) points vs.(3.1 ±0.6) points, F=5.783, P=0.006].The number of patients requiring analgetics was lower in the group R than that in the group F1 and F2 at postoperative 2 h (1 case vs.7 cases vs.5 cases,χ2 =6.058, P=0.048). Conclusion Local anesthesia with ropivacaine in patients after lymphatic venous anastomosis can achieve good postoperative analgesia .

Objective To observe the clinical efficacy of scalp acupuncture plus body acupuncture in treating diarrhea-predominant irritable bowel syndrome (D-IBS). Method Totally 122 D-IBS patients were randomized into a scalp acupuncture group (41 cases), a body acupuncture group (41 cases), and a combined group (40 cases). The scalp acupuncture group was intervened by acupuncture at the Stomach and Intestine Zones on the head; the body acupuncture group was by ordinary body acupuncture; the combined group was by both scalp acupuncture and body acupuncture. The symptom score of traditional Chinese medicine (TCM) was evaluated prior to the treatment, at the end of the first and second treatment courses, and after the whole intervention; the clinical efficacies were also compared among the three groups. Result The symptom scores of the combined group were significantly lower than that of the scalp acupuncture group and body acupuncture group respectively at the end of the second treatment course and after the whole intervention (P<0.05); after the whole intervention, the cured and markedly-effective rate was 62.5% in the combined group, significantly higher than 24.4% in the scalp acupuncture group and 29.3% in the body acupuncture group (P<0.05). Conclusion Scalp acupuncture plus body acupuncture can produce a satisfactory clinical efficacy in treating D-IBS, better than body acupuncture or scalp acupuncture alone; its advantages include rapid onset of action, significant effect, and reducing intestinal inflammation, etc.

Child ; Child, Preschool ; Humans ; Male ; Posterior Leukoencephalopathy Syndrome

Clinical teaching effect is directly affected by internship tutors’quality which is not very good at present. For this reason,a questionnaire on teachers and students was made and several solutions were put forward by analysis on the survey results.

ObjectiveTo study the effect of P21 (WAF1/CIP1) and cyclin D1 and their relationship in colorec- tal carcinoma. Methods The expression of P21 and cyclin D1 was studied in 40 colorectal carcinoma and 10 normal tissues using S-P immunohistochemical technique. ResultsDecreased expression of P12 and overexpression of cyclin D1 were revealed in colorectal carcinoma. Decreased expression of P21 was related to lymph node metastasis. No cor- relation was found between cyclin D1 and clinicopathological parameters. Conclusion Decreased expression of P21 and overexpression of cyclin D1 may be involved in colorectal tumorigenesis,and were associated with poor prognosis. No correlation was found between P21 and cyclin D1 in colorectai carcinoma.

Aim To investigate the effects of myricetin on the migration and invasion of hepatoma SMMC-7721 cells.Methods SMMC-7721 cells were treated with different concentrations of myricetin.Migration and invasion of SMMC-7721 cells were examined by Wound healing and Transwell, and the expression of E-cadherin and N-cadherin was detected by RT-qPCR and Western blot.Results Myricetin may inhibit the viability of SMMC-7721 cells via different concentration(10~40 μmol·L-1);furthermore, myricetin might also inhibit the migration and invasion of hepatoma SMMC-7721 cells.Meanwhile with the increasing of myricetin concentration, both filopodia and lamellipodia formation was reducd, and 7721 cells displayed in more integrity.And data from RT-qPCR and Western blot demonstrated that myricetin may up-regulate the expression of E-cadherin, simultaneously, down-regulate N-cadherin in SMMC-7721 cells.Conclusion Myricetin may influence the cell migration and invasion through up-regulating the expression of E-cadherin, simultaneously, down-regulating N-cadherin and activate cytoskeleton remolding of SMMC-7721.

OBJECTIVE:To provide reference for rational drug use in the clinic. METHODS:The calculation was carried out in type,amount and consumption sum of Chinese patent medicines containing Salvia miltiorrhiza in our hospital during 2011-2014. These data were analyzed,classified and sorted by DDDs sequence and the method of pharma-coeconomics with Excel statistically. RESULTS:The consumption sum of Chinese patent medicines containing S. miltiorrhiza took on little changes in our hospital dur-ing 2011-2014,decreasing by 10.52% in 2012 compared to 2011 but increasing by 8.49% in 2013 compared to 2012. The order of DDDs kept stable,indicating that Chinese patent medicines containing S. miltiorrhiza were used frequently in 4 year. The order of consumption sum also kept stable relatively. CONCLUSIONS:The utilization of Chinese patent medicines containing S. miltiorrhi-za in our hospital is rational. Those with suitable prices and proved efficacy take a great share in the clinical application.

Objective To study the mechanism of lentinum's promotion on carvedilol's effects on dilated cardiomyopathy's heart function.Methods SD rat model of dilated cardiomyopathy was established with doxorubicin hydrochloride.The rat model was divided into blank control group,carvedilol group,lentinan group,carvedilol + lentinan group.Rats in the blank control group were given 2 mL of 0.9％ sodium chloride solution.Rats in the carvedilol group were given 10 mg·kg-1of carvedilol and 2 mL of 0.9％ sodium chloride solution.Rats in the lentinan group were given 1 mg·kg-1 of lentinan,and 2 mL of 0.9％ sodium chloride solution.Rats in the carvedilol + lentinan group were given10 mg· kg-1 of carvedilol,1 rmg·kg-1 of lentinan,and 2 mL of 0.9％ sodium chloride solution.The heart function,irrflammatory factors and T lymphocytes were compared.Results The left ventricular ejection fraction (LVEF) in carvedilol + lentinan group and carvedilol group were significantly higher than that in blank control group and lentinan group (P ＜ 0.05),while Tei index was significantly lower (P ＜ 0.05).The LVEF in carvedilol + lentinan group was significantly higher than that in carvedilol group (P ＜0.05),while Tei index was significantly lower (P ＜0.05).The hs-CRP,TNF-α,II-6 and IL-8 in carvedilol + lentinan group and lentinan group were significantly lower than that in blank control group and carvedilol group (P ＜0.05),while IL-10,CD3+,CD4+ and CD8+ were significantly higher (P ＜ 0.05).The hs-CRP,TNF-α,II-6 and IL-8 in C + L group were significantly lower than in lentinan group (P ＜ 0.05),while IL-10,CD3+,CD4+ and CD8+ were significantly higher (P ＜ 0.05).Conclusion Lentinan could significantly promote carvedilol's effects on dilated cardiomyopathy's heart function through lowering down inflammatory factors and increasing T lymphocytes.

Objective To investigate analgesic effects of flurbiprofen in lower extremity liposuction for patients with primary lymphedema. Methods A total of 60 patients receiving lower extremity liposuction under general anesthesia were allocated to 3 groups:the control group (group A) received no analgesic drug 10-20 min before the end of operation, the parecoxib group (group B) received intravenous parecoxib 40 mg, and the flurbiprofen group (group C) received intravenous flurbiprofen 100 mg.The VAS was recorded at 1, 2, 6, 12, and 24 h after operation.Adverse reactions were also recorded . Results The VAS of rest pain and motion pain at 1, 2, 6, and 12 h were significantly lower in the group B than those in the group A (P<0.05);the VAS of rest pain and motion pain at 1, 2, and 12 h were significantly lower in the group C than those in the group A (P<0.05).The VAS at 1 and 2 h did not differ between the group B and C (P>0.05), but had significant difference at 6 and 12 h (P<0.05).No significant differences in the VAS at 24 h were observed among the three groups (P>0.05).Adverse reactions were not different among the three groups (P>0.05). Conclusion Both flurbiprofen and parecoxib sodium can achieve good postoperative analgesic effects in patients with lymphedema receiving lower extremity liposuction .