Objective To study the clinical characteristics of abnormal lipid metabolism in different types of elderly people with hypertension.Methods The clinical data,collected from the elderly people who underwent annual physical examination,the characteristics of dyslipidemia and abnormal lipid metabolism in different types of elderly people with hypertension were analyzed retrospectively. Results The prevalence of dyslipidemia was 69. 63％, in which the prevalence of hypercholesteremia and hypertriglyceridemia was 23. 65％, and 26. 71％ respectively. The prevalence of hypercholesteremia accompanied hypertriglyceridemia( mixed group) was 19. 27％, and normal group was 30. 37％. Hypertriglyceridemia group was easier to be accompanied with hypertension than normal group and HTC group(P ＜0. 05). The hypertriglyceridemia had higher risk of cardiovascular and cerebrovascular diseases than norral group and HTC group( P ＜ 0. 05 ). Conclusion The elderly people had high prevalence of dyslipidemia and metabolic syndrome,and with high prevalence of hypertension, which led to higher risk of cardiovascular and cerebrovascular diseases. The hypertriglyceridemia had more strong impact on cardiovascular and cerebrovascular diseases than hypercholesteremia.

Objective:To explore the effects of 1,25-dihydroxyvitamin D3 on renal expression of TGF-?1 and HGF in type 1 diabetic rats.Methods:30 Sprague-Dawley rats were randomized into 3 groups:normal control rats(group NC),diabetic rats(group DM ) and diabetic rats treated with 1,25-dihydroxyvitamin D3(group DC).Kidney-to-body weight ratio(KW/BW),mean glomerular volume(MGV),fractional mesangial area(FMA),urinary albumin excretion rate(UAER)and serum creatinine(Scr)were measured after 12 weeks of treatment,while transforming growth factor-betal(TGF-?1) expression in kidney cortex were observed by immunohistochemistry.The expression levels of TGF-?1 mRNA and HGF mRNA were detected by reverse transcription and polymerase chain reaction(RT-PCR) at the end of the experiment.Results:UAER,Scr,MGV,FMA and KW/BW ratio were significantly higher in the diabetic rats than those in the normal control rats(P

Long non-coding RNA (lncRNA) is a group of functional RNA molecules, which is more than 200 nu-cleotides in length, lacks ability of encoding protein and participates in all aspects of gene regulation. The current studies have indicated that some lncRNAs take part in regulating the process of breast cancer tumorigenesis and progression. This article reviewed the abnormal expression of lncRNA in breast cancer, its relationship to breast cancer growth, apoptosis, invasion and metastasis, and its function in early diagnosis, drug resistance and prognosis of breast cancer. This review was expected to offer an insight into a new target for the prediction, diagnosis and individual treatment of breast cancer.

Objective Compared with surgical operation,to investigate the clinical efficacy and advantages of interventional treatment in blunt liver traum.Methods 32 patients from July 2010 to October 2012,who were diagnosed as blunt liver trauma,received super selective hepatic artery embolization in Chinese People's Liberation Army in 98th Hospital.Another 27 ones received operation at the same time in Peolies's Liberation Army 98th (AAST grade Ⅱ to Ⅳ).Retrospective analysis of related cases was presented.The results were analyzed by t test.Results All of 32 patients that received super selective hepatic artery embolization were stanched bleeding successfully.All patients were followed up for 3 to 18 months,the mean follow-up time was 10 months,with no severe complications occurred or no lost cases.Conclusions Compared with surgical operation,interventional treatment had advantage that included eliable hemostasis,less operation time,minimally invasive and less hospitalization time.Interventional treatment had good effects on blunt liver trauma which were AAST grade Ⅱ to Ⅲ.

AIM: To study the effect of herbal compound poria prescription (CPP) on proliferation and differentiation in primary rat preadipocytes, and to explore the mechanism of this process. METHODS: Primary cultured rat preadipocyte proliferation was determined by cell counting and MTT spectrophotometry. Cell differentiation was determined by Oil Red O staining, and the expression of PPAR? mRNA was determined by RT-PCR. RESULTS: CPP inhibited the proliferation and differentiation of primary rat preadipocytes in a dose-dependent manner, and it also inhibited the expression of PPAR? mRNA. CONCLUSION: CPP inhibits the proliferation of primary rat preadipocytes and inhibits the preadipocyte differentiation by suppressing the expression of PPAR? mRNA.

Dizziness ; classification ; epidemiology ; Humans ; Vertigo ; classification ; epidemiology

Cisplatin is a first-line anticancer drug widely used in clinic. However, its resistance reduces its efficacy. With a non-specific cell cycle, cisplatin's main targets are nucleophilic protein, DNA and RNA in cells. Among cisplatin's multi-factorial resistance mechanisms, abnormal expression of transport protein, intracellular detoxification enhancement, DNA repair capacity increase and apoptosis blocking are the main mechanisms. Because traditional Chinese medicines (TCMs) have unique advantages in cancer treatment, their combination with cisplatin can improve the efficacy. In this paper, the authors summarized the advance in studies on cisplatin's resistance and the combination of TCMs and cisplatin in recent years.
Antineoplastic Agents ; administration & dosage ; pharmacology ; Antineoplastic Combined Chemotherapy Protocols ; therapeutic use ; Apoptosis ; drug effects ; Cell Cycle ; drug effects ; Cisplatin ; administration & dosage ; pharmacology ; Drug Resistance, Neoplasm ; drug effects ; Drugs, Chinese Herbal ; administration & dosage ; Humans ; Medicine, Chinese Traditional ; methods ; trends ; Neoplasms ; drug therapy ; pathology ; therapy

Objective To analyse the pathological changes and the causes of death in perioperation of newborns with congenital heart diseases from the neonatal autopsies. Methods 15 neonatal autopsy cases with congenital heart diseases were collected. Their pathological changes and the causes of death were reviewed. Results The perioperative mortality rate was 28.6%. The autopsy rate was 62.5%.The diagnostic consistence rate was 86.67%. The main causes of death included heart failure in 9 cases, pulmonary infection in 4 and stressful hemorrhage in adrenal gland in 2. Conclusion Attention to protect heart and lung will help to surgical success of newborns with congenital heart diseases.

Elaborated in this paper are the design and layout of library physical spaces ( including public space , collection space , reading space , popular science and academic exchange space , historical and cultural space , characteristic collection space) and library virtual spaces (including information commons, virtual research space, individualized digital space ) , which will be expanded with the increasing needs of users in digital environment .

Epithelial-mesenchymal transition (EMT),which means the transformation of epithelial cells into mesenchymal cells under the influence of cytokines,leading to pathological changes in tissues.According to recent research findings,EMT plays an important role in or-gan fibrosis.Various types of EMT in the fibrosis of hepatobiliary system,as well as the characteristics of each stage and the disease progres-sion,are described,which is of great significance for understanding the development,termination,and even reversion of EMT and fibrosis of hepatic and biliary epithelial cells.