Human papillomavirus type 16(HPV 16)is associated with many tumor carcinogenesis particularly cervical cancer.HPV 16 variants has been found to show different geographic and ethic distributions according to epidemiologicat research.meanwhile,they also play an important role in virus persistent infections and disease progressions.Variants study has been a promising field in the research of HPV and its association with tumor research.

Objective To explore the experience of surgical treatment for appendiceal carcinoid.MethodsThe clinical data of 12 appendiceal carcinoid cases received surgery were retrospectively studied.ResultsPreoperatively,all the 12 cases were considered as appendicitis.The definite diagnosis was verified by pathologic study postoperatively.Among the 12 cases, tumors less than 1 cm 9 cases, between 1 cm to 2cm 2cases, but without serosal involvment or lymph node metastasis(2 cases) recieved simple appendectomy.One case with a tumor larger than 2cm and serosal involvment underwent fight hemicolectomy.ConclusionOwing to its lack of specific symptoms,the diagnosis of appendiceal carcinoid was usually reached after operation.The choice of surgical procedures should based on the size and depth of invasion of the tumor and lymph node metastasis status.

OBJECTIVE: To summarize the advances in the genetic susceptibility to coronary artery disease (CAD) and explore the heritable basis of the disease.DATA SOURCES:Related articles in English from January 1990 to June 2006 were searched in Pubmed and EMCC databases with the terms "gene, coronary artery disease and myocardial infarction". Meanwhile, the CMCC database was searched for the relevant articles published between January 2000 and June 2006 in Chinese.STUDY SELECTrON: After the preliminary selection,relevant literatures on genetics of CAD and myocardial infarction(MI)were selected, and those with obvious indifferent contents or with less correlation were excluded.DATA EXTRACTION: Data of 49 articles were mainly extracted from the selected literatures providing solid evidence to elucidate the genetic susceptibility to CAD or MI.DATA SYNTHESIS: The involved 49 articles showed that CAD is a complex multifactorial disorder which is believed to result from the interplay between a person's genetic makeup and various environmental factors. The heritable basis is increasingly recognized as a crucial component in the development of CAD. Recent work in the field of genetics has lead to determining key genes associated with the susceptibility for CAD and MI through genome-wide linkage scans and large-scale gene-association studies as core human genetics approaches These susceptibility genes involve diverse functions, including dyslipidemia, vascular homeostasis, endothelial dysfunction, inflammation and immunity.CONCLUSION: The identification of genes that predispose to or directly cause CAD provides new insights into the pathogenesis of this disorder. However, the precise role of genetic factor in the CAD or MI events and the personalized gene-specific therapy await further investigation.

Objective: To investigate the diagnostic value of salivary gland scintigraphy for primary Sj?gren’s syndrome (pSS). Methods:This study took 50 pSS patients and 50 healthy women as the control group. All of them were performed salivary gland scintigraphy. We observed the imaging of salivary gland scintigraphy for two groups, and evaluated their salivary gland function. Results: In 50 patients with pSS, eight patients (16.0%) of bilateral parotid and submandibular glands were functioned well. While the function of bilateral parotid function and/or bilateral submandibular gland were observed reduction in other patients with pSS. The uptaking function decreased obviously in the typical patients with pSS, who are with bilateral parotid and submandibular glands. The uptake of 99TcmO4-was decreased in salivary glands, and the uptake of the oral cavity was lessened. After taken vitamin C tablets, there was no obvious concentration of 99TcmO4-. The time-radioactive type curve has continued to rise. The UR, S/T, SR and V of pSS patients were significantly lower than the control group, and the differences were statistically significant (P<0.01). Conclusion: Salivary gland scintigraphy is a non-invasive diagnosis with high-value for primary Sj?gren’s syndrome patients.

Text mining provides a new approach for drug repositioning, and the emerging databases and their corresponding tools provide more and more convenience for drug repositioning by text mining.The methods and tools for studying drug repositioning by text mining and their successful application examples were thus described in this paper in order to provide reference for the researchers interested in this field.

After the basic properties of literature-related citation network, co-authorship network and co-words network were analyzed and the advances in their application research were summarized in aspects of their construc-tion methods, size and research depth, it was pointed out that article similarity networks could be constructed using the article similarity algorithm, and their basic properties and features were analyzed.

This article consults the literature on acupuncture-moxibustion treatment for the non-spastic stage of cerebral stroke published from 2001 to 2014, makes a summary and analysis from meridians, point selection, acupuncture reinforcing-reducing techniques and electoacupuncture application and points out some problems such as valuing acupuncture and neglecting moxibustion, valuing acupuncture and neglecting medicine, and neglecting point selection based on syndrome differentiation in acupuncture-moxibustion treatment for the non-spastic stage of cerebral stroke. The article also objectively assesses the position of acupuncture-moxibustion treatment, puts forward relevant solving ideas and emphasizes the importance of acupuncture manipulation and the necessity for combining Chinese herbal medicine to treat the non-spastic stage of cerebral stroke.

Objective_To identify the anti-HBV efficiency of AAV-IFNαby infecting HepG2.2.15 cell line, and to develop a new strategy of curing hepatitis B.Methods_Firstly,recombinant vector was packaged into AAV by three plasmids co-transfection method;then AAV-IFNαinfected HepG2.2.15 cell line, and samples were collected on the 1st, 3rd,6th and 9th day;thirdly, The time-course of HBV DNA,HBsAg and HBeAg were detected by qPCR and ELISA.The proliferation of HepG2.2.15 cells detected by MTT.Results_Recombinant AAV-IFNαcan significantly inhibit HBV replication and expression in vitro because of the proliferation of HepG2.2.15 cells inhibited by AAV6-IFNα( P<0.05) .Conclusions_AAV-IFNαis a potential antiviral product for hepatitis B.

Co-occurrence network of major MeSH terms and all MeSH terms was constructed respectively with MEDLINE-covered pharmacological literature as its example.The degree, closeness and betweenness of centrality in different nodes of the two co-occurrence networks were analyzed , the distribution of scale-free properties in the two co-occurrence networks was tested, the small-world effect of the two co-occurrence networks was identified by comparing their overall properties ( average distance and clustering coefficient ) , which showed the scale-free properties and small-world effect of the two co-occurrence networks.The co-occurrence network of all MeSh terms could thus be used in analysis of network properties while that of major MeSH terms could thus be used in analysis of subject contents.