3.Investigation on relation between recurrent spontaneous abortion and antiphospholipid thrombosis syndrome
Acta Universitatis Medicinalis Anhui 2001;(2):137-138
Objective To investigate the causes of recurrent spontaneous abortion(RSA) and to know the relation between RSA and antiphospholipid thrombosis syndrome(APL-T). Methods ELISA and PTT-LA were used to detect anticardiolipin antibody(ACA) and lupus anticoagulant(LA) in 32 patients with RSA and 20 normal controls(NC). Results There were 17 positive of antiphospholipid antibody(APA) in RSA group. The incidence was significantly higher than that in NC group. The incidence of LA was also significantly higher than that in NC group. 8 patients were diagnosed as APL-T. Conclusion LA may be the more important reason of RSA. It should be considered as APL-T when RSA is unexplained.
5.Progress in research and application of bioactive scaffolds in bone tissue engineering
Chinese Journal of Orthopaedic Trauma 2002;0(02):-
The research on novel scaffold materials is now characterized by a transition from single element to composition, from inert materials to bioactive materials, and from macro- level to micro- level. With the rapid development of nano- technology and life sciences, the two concepts of nano- modification and biomimic construction joined the mainstream of the scaffold research. And in this field, the theory of bone generation net has been recently explored systematically and comprehensively. As a result, it has now become a research focus to obtain ideal bioactive scaffolds on the basis of current investigation. This paper highlights several types of promising scaffolds, discusses their recent research and application, and reviews the present situation concerning bioactive scaffolds
6.Proteomics of human tears: towards clinical applications
Chinese Journal of Experimental Ophthalmology 2015;33(5):385-388
Tear fluid is a complex body fluid,which may contain thousands of protein/peptides and other molecules.Studies have determined that the changes in the chemical compositions of tears play an important role in some diseases and their progression.Tear fluid is a useful and easily accessible source for understanding ocular surface diseases,other eye diseases,and systemic diseases.It can also be used for identification of biomarkers for clinical applications and pharmaceutical development.Therefore,quantitative proteomic analysis of tears may provide very important information for diagnosis and treatment of eye diseases or the development of new drugs.Knowledge of the current proteomic technologies for tear analysis is helpful for conducting studies.In addition,ophthalmologists should pay close attentions to the association between tear proteomic changes and eye diseases,recent advances in tear proteomics and their applications in studying ocular surface diseases and conditions.
7.Clinical value of 64 slice spiral CT low dose chest scan in diagnosis of pulmonary tuberculosis
Chinese Journal of Primary Medicine and Pharmacy 2017;24(12):1798-1801
Objective To investigate the clinical value of 64 slice spiral CT low dose chest scan in the diagnosis of pulmonary tuberculosis.Methods From January 2015 to January 2016,45 patients with suspected pulmonary tuberculosis were studied.All patients underwent routine chest CT scan and low dose chest CT scan.To compare the difference of radiation dose related parameters between normal dose chest CT scanning and low dose chest CT scan.To observe the display of the characteristics of lung disease by routine dose chest CT scanning and low dose chest CT scan.Results In 45 patients,there were a total of 30 patients were diagnosed with tuberculosis.The diagnostic sensitivity,specificity and diagnostic coincidence rate of conventional CT scan and spiral CT low-dose scan were 93.3% and 86.7% respectively.In low dose CT scanning radiation dose related parameters,the effective dose [(1.36±0.22)mSv vs.(5.24±0.68) mSv],CT dose index[(31.8±3.7) vs.(51.2±6.3)] and dose length product[(35.4±5.4)mGycm vs.(137.9±26.1) mGycm]were significantly lower than those of the conventional dose CT scan,the differences were statistically significant (all P<0.05).Conventional dose and low dose CT scan could show the lung lesions of pulmonary tuberculosis.Comparison between the two groups,low dose CT scanning on the burr sign and grinding glass shadow display rate was low.Compared with the conventional dose CT scanning,the difference was statistically significant (P<0.05).Conclusion In the diagnosis of pulmonary tuberculosis,the radiation dose of 64 slice spiral CT is significantly decreased,be able to clear most of the lung lesions.However,the effect is poor in the display of the grinding glass and the thin and short burr.
8.Needle-knife precut versus Plough-knife precut in difficult biliary cannulation
China Journal of Endoscopy 2016;22(2):50-52
Objective To discuss which is more efficient between Needle-knife precut and Plough-knife precut in difficult biliary cannulation. Methods The difference in the average time of cannula, percentage of cannula achieve-ment and the complication rate between the two kinds of operation were compared. Results The percentage of can-nula achievement about the Needle-knife precut is higher than Plough-knife precut, while there is no notable differ-ence in average time of cannula and the complication rate between the two precuts. Conclusion Needle-knife precut is more efficient than Plough-knife precut in difficult biliary cannulation, if guide wire can not get into pancreatic duct.
9.Characteristics and management of 301 cases of civilian firearm injuries in maxillofacial region
Journal of Practical Stomatology 2001;17(3):220-222
Objective: To view the characteristics and the primary treatment of civilian firearm wound in the maxillofacial region.Methods: 301 cases of the casualties admitted to our hospital were retrospectively investigated,the epidemic, etiology, wound characteristics, and treatments of the patients were viewed respectively. Results: Of all the cases, the ratio of male to female was 5.1∶1.0. 57% of the injuries were caused by gunshot, 66% were with multiple injuries.16% combination wound were craniocerebral injuries. In this group of patients, more than 900 wound tracks were found, 72% of the tracks were nonpenetrating and 67% of those were with foreign bodies lodged in. Burns with blast injuries were the main complex wounds, which mostly occurred in explosion. The treatments mainly included life maintaining, earlier debridement and infection control. Conclusions: The maxillofacial firearm injuries are complex and have their own characteristics depending on the firearms, the wound styles and the regional anatomy. All the factors must be considered when treatment is given.
10.The present understanding of serine proteinase inhibitor-9
International Journal of Surgery 2010;37(6):404-407
Serine proteinase inhibitor9(P1-9),a charac-teristic member of serpins,has been identified as the only inhibitor of granzyme B(GrB).Accumulated evidence suggested that PI-9 inhibits GrB-induced apoptosis by blocking DNA fragmentation of target cell.Physiologically,PI-9 could protect cytotoxic lymphocytes from committing autolysis or fratricide,and play an important role in facilitating immunologic tolerance of immune-privileged sites.In addition,evidences in recent years suggest that PI-9 Was also involved in vailous pathologic processes,such as inflammation,trans plantation and immune tolerance of tumor.