Electromyography ; Humans ; Occupational Health

Objective:To investigate the risk factors of preterm premature ruPture of membrane(PPROM) and their pregnancy outcomes.Methods:The clinical data of 95 cases of patients with PPROM admitted and treated in our hospital from October 2013 to July 2016 were collected,which were divided into two groups,observation group(gestational week 28-33 +6 weeks) and control group(gestational week 34-36 +6 weeks).The risk factors of PPROM,delivery method and pregnancy outcomes were analyzed.Results:Genital tract infection was the main risk factor of PPROM(33.68％).of the incidences of cesarean delivery,neonatal asphyxia,neonatal infections and neonatal death in observation group were significantly higher than those of control group,the differences were statistically significant(P ＜ 0.05).The intrauterine infection and puerperal infection rates of observation group of were higher than those of control group,but differences were not statistically significant (P ＞ 0.05).Conclusions:Reproductive tract infections is the most important risk factor of PPROM.The purpose of active treatment including tocolytic therapy and prevention of infection for the patients with PPROM less than 34 weeks is to prolong the gestational weeks,to reduce the rate of neonatal complication,and to improve the pregnancy outcome.

Objective:To study the expression of Pleiotrophin and Midkine protein in endometrium of endometriosis and its clinical significance.Methods:Expressions of Pleiotrophin and Midkine protein were examined by immunohistochemical staining method in 30 endometrial samples of endometriosis(study group) and 29 endometrium of uterine fibroid(control group).Result:Pleiotrophin protein mainly expressed in the membrane and plasma of glandular epithelium of endometrium.Midkine protein mainly expressed in the plasma of grandular epithelium of endometrium and expressed in nuclei in some samples.The expression of Pleiotrophin and Midkine protein in endometriosis was significantly higher than that in the control group(P

Diabetes Mellitus, Type 2 ; drug therapy ; Humans ; Hypoglycemic Agents ; therapeutic use ; Non-alcoholic Fatty Liver Disease ; drug therapy

Aging ; Arteriosclerosis ; pathology ; Blood Vessels ; pathology ; Cellular Senescence ; Humans ; Medicine, Chinese Traditional

The paper introduces using MedlineR to carry out data mining from Medline, for observing the gene relation, and using Pajek to realize the visualization of the results. Practice proofs that MedlineR could help researchers come up with assumptions in the field that they are interested in, and get a visual fingerprint. These results are the bases to go to more complex literature data mining and an important supplementary to experimental methods.

Objective To observe the clinical efficacy of tongue acupuncture plus balloon dilatation in treating deglutition disorders due to achalasia of the cricopharyngeus muscle after cerebral stroke.Method Forty-eight patients with deglutition disorders due to achalasia of the cricopharyngeus muscle after cerebral stroke were randomized into a treatment group and a control group, 24 cases each. The two groups both received conventional rehabilitation training. In addition, the treatment group was given tongue acupuncture plus balloon dilatation, and the control group was by balloon dilatation alone. The two groups were treated once a day, for a total of 4 weeks. The water drinking test score and Standardized Swallowing Assessment (SSA) were evaluated before and after the treatment.Result The water drinking test and SSA scores were significantly changed after the intervention in both groups (P<0.05). After the treatment, the water drinking test and SSA scores in the treatment group were significantly different from those in the control group (P<0.05).Conclusion Tongue needling plus balloon dilatation is an effective approach in treating deglutition disorders due to achalasia of the cricopharyngeus muscle after cerebral stroke.

OBJECTIVE:To prepare zolmitriptan-diclofenac microemulsion,and conduct quality evaluation and in vitro trans-dermal study. METHODS:Using solubility and microemulsion area in pseudo-ternary phase diagram as indexes,the types of oil phase and mixed emulsifier ratio of zolmitriptan-diclofenac microemulsion were screened;the microemulsion quality was inspected using particle size,Zeta potential,appearance and stability. HPLC was used to measure the contents of zolmitriptan and diclofenac. Transdermal diffusion test instrument was used,2 g microemulsion was smeared in cuticle of extracouporeal rats'skin,and cumula-tive transdermal rate in 24 h was determined. RESULTS:The microemulsion formulation was as follow as 10% oil phase(octanoic acid triglyceride),25% mixture emulgator [polysorbate 80-brij 97 (1:1)],8.3% propylene glycol and 25 mg zolmitriptan,1.25 mg diclofenac,and water adding to 100 mL. The average particle size of prepared microemulsion was(28.2±2.5)nm,Zeta poten-tial was(-3.25±0.33)mV,the appearance was rounding;the microemulsion showed no stratification or flocculation at room tem-perature after placed for 1 month. Contents of zolmitriptan and diclofenac were 0.248 mg/mL,12.46 mg/mL(n=3);24 h cumula-tive transdermal rates were 80%,75%. CONCLUSIONS:Zolmitriptan-diclofenac microemulsion is prepared,and its in vitro trans-dermal ability is good.

Atrial fibrillation is the most common arrhythmia in clinical practice.However,the therapeutic effects of traditional antiarrhythmic medicines are far from satisfactory,because of the high rate of arrhythmia recurrence and the potential proarrhythmia effect.Recently,with the further investigation of the mechanisms that initiate and perpetuate atrial fibrillation,and the support of extensive data from clinical trials and animal experiments,thera-peutics based on anti-inflammation,antioxidation,regulation on renin-angiotensin-aldosterone system(RAAS)and gap junction may be new therapeutic targets for the treatment of arrhythmia.In this paper,the potential molecular mechanisms involved in these processes and several clinical trials about some non-traditional antiarrhythmic medi-cines were reviewed,in order to propose a new idea about the development of antiarrhythmic medicines.

FJ, with 9.7 times difference between the highest and the lowest. CONCLUSION: Prepared with different base materials, the permeation ability of of the preparation will be different.