1.Dermatomyositis: Clinical Profile And Association with Malignancies in 43 Patients
Yap EWY ; Lee BS ; San VE ; See CKL ; Wong NKL ; Choon SE
Malaysian Journal of Dermatology 2014;33(-):2-8
Introduction: Dermatomyositis is a rare idiopathic inflammatory myopathy with distinctive cutaneous
manifestations. This study aims to determine the demographic characteristics, clinical features and
associated malignancies in patients with dermatomyositis.
Materials & Methods: Dermatomyositis is a rare idiopathic inflammatory myopathy with distinctive
cutaneous manifestations. This study aims to determine the demographic characteristics, clinical
features and associated malignancies in patients with dermatomyositis.
Results: Forty-three cases were identified, with female to male ratio of 1.26:1. Mean age of onset was
47.8 +18.0 years. Malay and Chinese patients made up the bulk of the patients, contributing 53.5% and
44.2% respectively. Photosensitive rash was the commonest clinical presentation, occurring in 55.8%
of the patients, followed by Gottron’s papules (46.5%), heliotrope rash (44.2%), alopecia (23.3%)
and calcinosis (9.3%). Median Creatinine Kinase level was 293IU/L (interquartile range 89-1166),
Lactate Dehydrogenase 641IU/L (interquartile range 459-986) and Aspartate Transaminase 70.5IU/L
(interquartile range 41.5-156.25). Concomitant malignancies occurred in 14 patients (32.5%), the
commonest being nasopharyngeal carcinoma (6 patients), followed by gastrointestinal tumours (3
patients), breast cancer (2 patients) and lymphoproliferative disorders (2 patients) and lung cancer
(1 patient). Of these 14 patients, malignancies were detected in 10 patients within the first year, and
2 patients within the second year after diagnosis of DM. Two patients had malignancies diagnosed
within 6 months prior to the diagnosis of DM. Malignancy accounts for 64.7% of the 17 mortalities
recorded. The proportion of Malay patients with paraneoplastic dermatomyositis with respect to the
total number of Malay new clinic attendees over the past 13 years is 7 in 10,000 persons whereas in
Chinese patients, the proportion is 15 in 10,000 persons.
Conclusion: Malignancy is found in about a third of all patients, with Chinese predisposition seen.
This could explain why nasopharyngeal carcinoma is most prevalent in our centre.
2.Can Paediatric Femoral Fracture Hip Spica Application be Done in the Outpatient Setting?
Yap ST ; Lee NKL ; Ang ML ; Chui RW ; Lim KBL ; Arjandas M ; Wong KPL
Malaysian Orthopaedic Journal 2021;15(No.1):105-112
children with femur fractures. This study compares the
outcomes of spica cast application, in terms of quality of
fracture reduction and hospital charges when performed in
operating theatre versus outpatient clinics at a local
institution.
Materials and Methods: A total of 93 paediatric patients,
aged between 2 months to 8 years, who underwent spica
casting for an isolated femur fracture between January 2008
and March 2019, were identified retrospectively. They were
separated into inpatient or outpatient cohort based on the
location of spica cast application. Five patients with
metaphyseal fractures and four with un-displaced fractures
were excluded. There were 13 and 71 patients in the
outpatient and inpatient cohort respectively who underwent
spica casting for their diaphyseal and displaced femur
fractures. Variables between cohorts were compared.
Results: There were no significant differences in gender,
fracture pattern, and mechanism of injury between cohorts.
Spica casting as inpatients delayed the time from assessment
to casting (23.55 ± 29.67h vs. 6.75 ± 4.27h, p<0.05),
increased average hospital stay (41.2 ± 31.1h vs. 19.2 ±
15.0h, p<0.05) and average hospital charges (US$1857.14 vs
US$775.49, p<0.05). Excluding the un-displaced fractures,
there were no significant differences in the period of cast
immobilisation and median follow-up length. Both cohorts
had a similar proportion of unacceptable reduction and
revision casting rate.
Conclusion: Both cohorts presented similar spica casting
outcomes of fracture reduction and follow-up period. With
spica cast application in operating theatre reporting higher
hospital charges and prolonged hospital stay, the outpatient
clinic should always be considered for hip spica application.
3.Do We Ever Need to Fix Clavicle Fractures in Adolescents?
Lim KBL ; Olandres RA ; Cheow X ; Thng M ; Teo NMHZ ; Pereira N ; Chan PXE ; Lee NKL
Malaysian Orthopaedic Journal 2023;17(No.3):33-41
Introduction: Clavicle fractures in adults are increasingly
being treated by surgical fixation following reports of
symptomatic non-union, malunion and poor functional
outcome with conservative treatment. This has led to a
similar trend in the management of clavicle fractures in
adolescents. This study aims to evaluate the outcome and
complications of non-operatively treated clavicle fractures in
adolescents.
Materials and methods: This is a retrospective, single
institution study on adolescents aged 13-17 years who
sustained a closed, isolated clavicle fracture, between 1997-
2015. Clinical records were reviewed for demographic
information, injury mode, time to radiographic fracture
union, time to re-attainment of full shoulder range of motion
(ROM), and time to return to full activities and sports.
Complications and fracture-related issues were recorded.
Radiographs were analysed for fracture location,
displacement and shortening.
Results: A total of 115 patients (98 males, 17 females; mean
age:13.9 ± 0.89 years) were included for study. 101 (88%)
sustained a middle-third fracture while the remainder
sustained a lateral-third fracture. A total of 96 (95%) of the
middle-third fractures were displaced, and 12 (86%) of the
lateral-third fractures were displaced. All displaced fractures
in this study had shortening. Sports-related injuries and falls
accounted for 68 (59%) and 34 (30%) of the cases
respectively. Overall, the mean time to radiographic fracture
union was 7.8 ± 4.35 weeks; there were no cases of nonunion. Full shoulder ROM was re-attained in 6.6 ± 3.61
weeks, and full activities and sports was resumed in 11.4 ±
4.69 weeks. There were 5 cases of re-fracture and a single
case of intermittent fracture site pain.
Conclusion: Clavicle fractures in adolescents can and
should be treated non-operatively in the first instance with
the expectation of good outcomes in terms of time for
fracture union, reattainment of shoulder full range of motion,
and return to activities. Surgical stabilisation should be
reserved for cases for which there is an absolute indication.