The current study aimed to determine efficacy of the Acceptance and Commitment Therapy (ACT) for the emotional dysregulation and mental health of visually impaired adolescents. In a quantitative pre-post design, a purposive convenient sample of seven visually impaired adolescents with age range of 18 to 23 was recruited. Difficulties in emotion regulation scale were used to recruit the participants. After baseline assessment participants were subjected to six individual sessions of acceptance and commitment therapy. One week after the completion of intervention phase post test scores were obtained. A paired sample t-test and Reliable Change Index were applied. Results showed that there was significant difference of emotion dysregulation and mental health. Individual analyses were also performed. Tau-u statistics showed that ACT is an effective approach to enhance emotion dysregulation and mental health issues in visually impaired adolescent. The results of the study have important implications for clinical practitioners.