To determine if retrobulbar administration of chlorpromazine can alleviate the pain and promote lowering of intraocular pressure in absolute glaucoma, ten patients with painful absolute glaucoma received retrobulbal injection of 1.5 cc each of xylocaine and chlorpromazine. Pre- and post- injection intraocular pressures and pain grading were compared and analyzed statistically using the T test (L=0.01, 99.9%).Signs and symptoms of hypotension were monitored.A 75% reduction of pain was noted one hour post-injection and 95% three months post-injection in 9/10 patients.Intraocular pressure decreased by 30% in 7/10 patients one day post injection.Pressure-lowering effect however was not sustained for three months
Human ; GLAUCOMA ; CHLORPROMAZINE ; XYLOCAINE